A Randomized Controlled Trial of Omega 3 Fatty Acids in Rosacea Patients with Dry Eye Symptoms
Abstract
Objective or purpose: To evaluate the efficacy of dietary omega-3 fatty acids (O3FAs) in rosacea patients having dry eye symptoms. METHODS: A prospective, interventional, randomized, double-masked, placebo-controlled, multi-centric study was done. Symptomatic patients with rosacea were recruited based on their response to (Dry Eye Scoring System, DESS©); a score of 0-3 was assigned to dry eye-related symptoms like ocular fatigue, blurring of vision, itching or burning, sandy or gritty sensation, and redness, respectively (DESS©). Subjects were (n = 130) were randomized to receive either O3FAs (n = 65) or placebo (n = 65) capsules (olive oil) twice daily for 6 months. Patients were evaluated at baseline, 1, 3, and 6 months. Change in subjective dry eye symptoms was the primary outcome measure. Change in meibomian gland score (MGS), Schirmer score, and tear film breakup time (TBUT) were the secondary outcome measures. RESULTS: Repeated-measures ANOVA revealed that there was a significant (p < 0.001) change in symptoms (F(1.506, 88.825 = 315.193), MGS (F(1.336, 78.796 = 84.438), Schirmer score (F(1.322, 78.022 = 86.559), and TBUT (F(1.354, 79.898 = 179.020.559) in O3FA group as compared to placebo group. Post-hoc test revealed that there was a significant change in dry eye symptoms at all points of time; there was a significant change in MGS, Schirmer score, and TBUT also, but only after 3 months of intervention. Linear regression established that symptom severity could signific…
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Aside from several large trials conducted in India by Bhargava et al., previous clinical trials involved fewer than 125 total patients.
“Aside from several large trials that were conducted in India by Bhargava et al.,15–18 the previous clinical trials involved fewer than 125 total patients.”
From n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease (2018) · cites this paper as [17]
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Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464 · see citing works
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n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease
The Dry Eye Assessment and Management Study Research Group (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709691 · Cited by 274 · see citing works
The Eye, Oxidative Damage and Polyunsaturated Fatty Acids
Saccà, S. C., Cutolo, C. A., Ferrari, D., Corazza, P., & Traverso, C. E. (2018) · Nutrients · doi:10.3390/nu10060668 · Cited by 150 · see citing works
- Authors
- Bhargava, R., Chandra, M., Bansal, U., Singh, D., Ranjan, S., & Sharma, S.
- Affiliations
- Sharda University (IN)
- Department of Ophthalmology, Laser Eye Clinic, Noida, India
- Corresponding author
- Bhargava, Rahul
- Venue
- Current Eye Research
- Publisher
- Informa UK Limited
- Published
- 2016-04-06
- Volume
- 41
- Issue
- 10
- Pages
- 1274-1280
- ISSN
- 0271-3683 (ISSN-L)
- 1460-2202
- OpenAlex
- W2321640631
- Cited by
- 67
- References
- 1
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 5
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Keywords
- omega-3 fatty acids, rosacea, dry eye symptoms, dietary supplementation, meibomian gland dysfunction, tear film break-up time, Schirmer test, ocular surface disease
- MeSH terms
- Administration, Oral, Adult, Aged, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Rosacea, Tears, Dry Eye Syndromes, Fatty Acids, Omega-3, Treatment Outcome, Young Adult
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