Cited by 464Fatty Acid Research and HealthAdipokines, Inflammation, and Metabolic DiseasesSphingolipid Metabolism and Signaling

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

Open access
Spite, Matthew, Clària, Joan, Serhan, Charles N.·2014·Cell Metabolism

Abstract

Inflammation is associated with the development of diseases characterized by altered nutrient metabolism. Although an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic diseases is sustained and detrimental. The resolution of inflammation involves the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling. Specialized proresolving lipid mediators (SPMs)-resolvins, protectins, and maresins-are novel autacoids that resolve inflammation, protect organs, and stimulate tissue regeneration. Here, we review evidence that the failure of resolution programs contributes to metabolic diseases and that SPMs may play pivotal roles in their resolution.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2013.10.006

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Arachidonic acid, the prototypical metabolite of LA, is commonly considered pro-inflammatory, but is also the natural precursor to specialized proresolving mediators (SPMs) of inflammation.

    “Arachidonic acid, the prototypical metabolite of LA, is also commonly considered pro-inflammatory, but is also the natural precursor to specialized proresolving mediators (SPMs) of inflammation.368, 369”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Cassatella MA 2003 The Neutrophil Basel Karger
  2. Houck JC 1979 Chemical Messengers of the Inflammatory Process Amsterdam Elsevier/North-Holland Biomedical Press

Cited by

Sorted by citations

Authors
Spite, M., Clària, J., & Serhan, C. N.
Affiliations
  • University of Louisville (US)
  • Hospital Clínic de Barcelona (ES)
  • Brigham and Women's Hospital (US)
Corresponding author
Serhan, Charles N.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2014-01
Volume
19
Issue
1
Pages
21-36
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2065295548
Cited by
464
References
130
Citations by year
2026: 37 · 2025: 28 · 2024: 20 · 2023: 23 · 2022: 33 · 2021: 49 · 2020: 43 · 2019: 53 · 2018: 27 · 2017: 47 · 2016: 35 · 2015: 48 · 2014: 20
FWCI
3.87
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (4r37gm038765-19)
  • National Heart, Lung, and Blood Institute (HL-106173, R01HL106173)
  • National Institute of General Medical Sciences (P20GM103492, P01GM095467, GM-095467, GM 103492, GM038765, R01GM038765, R37-GM038765)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords
resolvins, protectins, maresins, inflammation resolution, low-grade inflammation, metabolic disorders, tissue regeneration, neutrophil recruitment, autacoids
MeSH terms
Animals, Fatty Acids, Unsaturated, Humans, Inflammation, Metabolic Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review