Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Open accessAbstract
Inflammation is associated with the development of diseases characterized by altered nutrient metabolism. Although an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic diseases is sustained and detrimental. The resolution of inflammation involves the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling. Specialized proresolving lipid mediators (SPMs)-resolvins, protectins, and maresins-are novel autacoids that resolve inflammation, protect organs, and stimulate tissue regeneration. Here, we review evidence that the failure of resolution programs contributes to metabolic diseases and that SPMs may play pivotal roles in their resolution.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Arachidonic acid, the prototypical metabolite of LA, is commonly considered pro-inflammatory, but is also the natural precursor to specialized proresolving mediators (SPMs) of inflammation.
“Arachidonic acid, the prototypical metabolite of LA, is also commonly considered pro-inflammatory, but is also the natural precursor to specialized proresolving mediators (SPMs) of inflammation.368, 369”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [369]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1× · see citing works
“…2014 ª2014 Elsevier Inc. 27 as Ly6ChiCCR2hiCX3CR1low, have considerable plasticity and differentiate into reparative monocytes andmacrophages during the resolution of fibrosis and tissue regeneration (Ramachandran et al., 2012; Godwin et al., 2013; Nahrendorf and Swirski, 2013; Wynn et al., 2013).”
BackgroundAdipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works
Self-citationOh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works
Inflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works
Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
Samuelsson, B. O., Dahlén, S., LINDGREN, J. Å., Rouzer, C. A., & Serhan, C. N. (1987) · Science · doi:10.1126/science.2820055 · Cited by 2,233 · see citing works
Self-citationNathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183 · see citing works
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · cited 2× · see citing works
“WAT is characterized by the presence of adipocytes containing large unilocular lipid droplets, whereas BAT is mainly composed by multiloculated adipocytes containing large numbers of mitochondria (Rosen and Spiegelman, 2006).”
BackgroundEltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061 · see citing works
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Dinarello, C., Simon, A., & van der Meer, J. V. D. (2012) · Nature reviews. Drug discovery · doi:10.1038/nrd3800 · Cited by 1,813 · see citing works
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works
Self-citationLipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works
Self-citationForming functional fat: a growing understanding of adipocyte differentiation
Cristancho, A. G., & Lazar, M. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3198 · Cited by 1,382 · see citing works
Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
Calder, P. C. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04374.x · Cited by 1,351 · see citing works
Bedogni, G., Miglioli, L., Masutti, F., Tiribelli, C., Marchesini, G., & Bellentani, S. (2005) · Hepatology · doi:10.1002/hep.20734 · Cited by 1,250 · see citing works
Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189 · see citing works
Self-citationResolvin E1 and protectin D1 activate inflammation-resolution programmes
Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works
Self-citationCancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164 · see citing works
Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities
Tabas, I., & Glass, C. K. (2013) · Science · doi:10.1126/science.1230720 · Cited by 1,093 · see citing works
Jeffcoate, W. J., & Harding, K. G. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13169-8 · Cited by 1,089 · see citing works
Resolution of in flammation: state of the art, definitions and terms
Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045 · see citing works
Self-citationNguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works
Insulin Resistance, Hyperglycemia, and Atherosclerosis
Bornfeldt, K., & Tabas, I. A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.015 · Cited by 1,002 · see citing works
Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001 · see citing works
Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works
Self-citationSerhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works
Self-citationResolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996 · see citing works
Self-citationObesity, inflammation, and atherosclerosis
Rocha, V. Z., & Libby, P. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.55 · Cited by 994 · see citing works
Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., & Serhan, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042031 · Cited by 926 · see citing works
Self-citationAnnexin A1 and glucocorticoids as effectors of the resolution of inflammation
Perretti, M., & D'Acquisto, F. (2009) · Nature Reviews Immunology · doi:10.1038/nri2470 · Cited by 915 · see citing works
Macrophages are required for adult salamander limb regeneration
Godwin, J. W., Pinto, A. R., & Rosenthal, N. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300290110 · Cited by 829 · see citing works
Falagas, M. E., & Kompoti, M. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70523-0 · Cited by 820 · see citing works
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
Weber, C., Zernecke, A., & Libby, P. (2008) · Nature reviews. Immunology · doi:10.1038/nri2415 · Cited by 777 · see citing works
Resolvin D1 binds human phagocytes with evidence for proresolving receptors
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C., Yang, R., Petasis, N. A., & Serhan, C. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907342107 · Cited by 738 · see citing works
Self-citationMolecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins
Bannenberg, G. L., Chiang, N., Ariel, A., Arita, M., Tjonahen, E., Gotlinger, K. H., Hong, S., & Serhan, C. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4345 · Cited by 699 · see citing works
Self-citationResolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N. (2009) · Nature · doi:10.1038/nature08541 · Cited by 695 · see citing works
Self-citationMacrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694 · see citing works
Infection regulates pro-resolving mediators that lower antibiotic requirements
Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664 · see citing works
Self-citationThe plasma lipidomic signature of nonalcoholic steatohepatitis
Puri, P., Wiest, M. M., Cheung, O., Mirshahi, F., Sargeant, C., Min, H., Contos, M. J., Sterling, R. K., Fuchs, M., Zhou, H., et al. (2009) · Hepatology · doi:10.1002/hep.23229 · Cited by 655 · see citing works
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
Serhan, C. N., Dalli, J., Karamnov, S., Choi, A. J. S., Park, C., Xu, Z., Ji, R., Zhu, M., & Petasis, N. A. (2012) · The FASEB Journal · doi:10.1096/fj.11-201442 · Cited by 596 · see citing works
Self-citationSignalling role of adipose tissue: adipokines and inflammation in obesity
Trayhurn, P., & Wood, I. S. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331078 · Cited by 591 · see citing works
Wetzler, C., Kämpfer, H., Stallmeyer, B., Pfeilschifter, J., & Frank, S. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00029.x · Cited by 584 · see citing works
The resolution of inflammation
Buckley, C. D., Gilroy, D. W., Serhan, C. N., Stockinger, B., & Tak, P. P. (2012) · Nature reviews. Immunology · doi:10.1038/nri3362 · Cited by 580 · see citing works
Self-citationHyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis
Nagareddy, P. R., Murphy, A. J., Stirzaker, R. A., Hu, Y., Yu, S., Miller, R. G., Ramkhelawon, B., Distel, E., Westerterp, M., Huang, L., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.001 · Cited by 577 · see citing works
n–3 Fatty Acids in Cardiovascular Disease
Caterina, R. D. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1008153 · Cited by 568 · see citing works
Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works
Self-citationGonzález‐Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán‐Salvador, E., Titos, E., Martínez‐Clemente, M., López‐Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 556 · see citing works
Self-citationWound Macrophages as Key Regulators of Repair
Brancato, S. K., & Albina, J. E. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.08.003 · Cited by 508 · see citing works
Insulin resistance, inflammation, and non-alcoholic fatty liver disease
Tilg, H., & Moschen, A. R. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.005 · Cited by 470 · see citing works
The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza
Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanebe, T., Sakabe, S., Daidoji, T., Nakamura, S., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.027 · Cited by 460 · see citing works
Merched, A. J., Ko, K., Gotlinger, K. H., Serhan, C. N., & Chan, L. (2008) · The FASEB Journal · doi:10.1096/fj.08-112201 · Cited by 414 · see citing works
Self-citationTitos, E., Rius, B., González-Périz, A., López-Vicario, C., Morán-Salvador, E., Martínez-Clemente, M., Arroyo, V., & Clària, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100225 · Cited by 412 · see citing works
Self-citationTransgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
Hudert, C. A., Weylandt, K. H., Lü, Y., Wang, J., Hong, S., Dignass, A. U., Serhan, C. N., & Kang, J. X. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601280103 · Cited by 379 · see citing works
Self-citationAriel, A., Fredman, G., Sun, Y., Kantarcı, A., Dyke, T. E. V., Luster, A. D., & Serhan, C. N. (2006) · Nature Immunology · doi:10.1038/ni1392 · Cited by 363 · see citing works
Self-citationThe 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
Zhao, L., Moos, M. P. W., Gräbner, R., Pédrono, F., Fan, J., Kaiser, B., John, N. F. S., Schmidt, S., Spanbroek, R., Lötzer, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1099 · Cited by 353 · see citing works
Monocyte and macrophage heterogeneity in the heart
Nahrendorf, M., & Swirski, F. (2013) · Circulation Research · doi:10.1161/circresaha.113.300890 · Cited by 350 · see citing works
Gukovsky, I., Li, N., Todoric, J., Gukovskaya, A. S., & Karin, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.007 · Cited by 346 · see citing works
Resolution phase lipid mediators of inflammation: agonists of resolution
Serhan, C. N., & Chiang, N. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.05.012 · Cited by 332 · see citing works
Self-citationCarlin, A. M., Zeni, T. M., English, W. J., Hawasli, A. A., Genaw, J. A., Krause, K. R., Schram, J. L., Kole, K. L., Finks, J. F., Birkmeyer, J. D., et al. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182879ded · Cited by 321 · see citing works
Kanter, J. E., Kramer, F., Barnhart, S., Averill, M. M., Vivekanandan‐Giri, A., Vickery, T. W., Li, L. O., Becker, L., Yuan, W., Chait, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111600109 · Cited by 310 · see citing works
Self-citationPlasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial
Brasky, T. M., Darke, A. K., Song, X., Tangen, C. M., Goodman, P. J., Thompson, I. M., Meyskens, F. L., Goodman, G. E., Minasian, L. M., Parnes, H. L., et al. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt174 · Cited by 307 · see citing works
Hellmann, J. L., Tang, Y., Kosuri, M., Bhatnagar, A., & Spite, M. R. (2011) · The FASEB Journal · doi:10.1096/fj.10-178657 · Cited by 306 · see citing works
Self-citationCells, tissues, and disease : principles of general pathology
Majno, G., & Joris, I. (1996) · Cited by 300 · see citing works
Transcriptomic analyses of murine resolution-phase macrophages
Stables, M. J., Shah, S. H., Camon, E. B., Lovering, R. C., Newson, J., Byström, J., Farrow, S. N., & Gilroy, D. W. (2011) · Blood · doi:10.1182/blood-2011-04-345330 · Cited by 293 · see citing works
El Kebir, D., Gjorstrup, P., & Filep, J. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206641109 · Cited by 289 · see citing works
Mas, E., Croft, K. D., Zahra, P., Barden, A., & Mori, T. A. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.190199 · Cited by 270 · see citing works
Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat
Clària, J., Dalli, J., Yacoubian, S., Gao, F., & Serhan, C. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201272 · Cited by 264 · see citing works
Self-citationAcute and Chronic Inflammation
Klatt, E. C., & Kumar, V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4930-2.00002-5 · Cited by 253 · see citing works
Ariel, A., Li, P., Wang, W., Tang, W.-X., Fredman, G., Hong, S., Gotlinger, K. H., & Serhan, C. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509796200 · Cited by 247 · see citing works
Self-citationResolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents
Dalli, J., Winkler, J. W., Colas, R. A., Arnardottir, H. H., Cheng, C.-Y. C., Chiang, N., Petasis, N. A., & Serhan, C. N. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.11.010 · Cited by 246 · see citing works
Self-citationSchif‐Zuck, S., Gross, N., Assi, S., Rostoker, R., Serhan, C. N., & Ariel, A. (2010) · European Journal of Immunology · doi:10.1002/eji.201040801 · Cited by 236 · see citing works
Self-citationIsobe, Y., Arita, M., Matsueda, S., Iwamoto, R., Fujihara, T., Nakanishi, H., Taguchi, R., Masuda, K., Sasaki, K. A., Urabe, D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340612 · Cited by 235 · see citing works
Neuhofer, A., Zeyda, M., Mascher, D. G., Itariu, B. K., Murano, I., Leitner, L., Hochbrugger, E., Fraisl, P., Cinti, S., Serhan, C. N., et al. (2013) · Diabetes · doi:10.2337/db12-0828 · Cited by 232 · see citing works
Self-citationCells, tissues and disease principles of general pathology
Mulligan, P. T. (1997) · Biochemical Education · doi:10.1016/s0307-4412(97)85220-x · Cited by 227 · see citing works
González‐Périz, A., Planagumà, A., Gronert, K., Miquel, R., López‐Parra, M., Titos, E., Horrillo, R., Ferré, N., Deulofeu, R., Arroyo, V., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6250fje · Cited by 226 · see citing works
Self-citationAyoub, S. S. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9781139195737 · Cited by 218 · see citing works
The Immune System as a Sensor of the Metabolic State
Odegaard, J. I., & Chawla, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.001 · Cited by 215 · see citing works
Norling, L. V., Spite, M. R., Yang, R., Flower, R. J., Perretti, M., & Serhan, C. N. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003865 · Cited by 206 · see citing works
Self-citationHo, K. J., Spite, M., Owens, C. D., Lancero, H., Kroemer, A. H. K., Pande, R., Creager, M. A., Serhan, C. N., & Conte, M. S. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091082 · Cited by 204 · see citing works
Self-citationProresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds
Tang, Y., Zhang, M. J., Hellmann, J. L., Kosuri, M., Bhatnagar, A., & Spite, M. R. (2012) · Diabetes · doi:10.2337/db12-0684 · Cited by 204 · see citing works
Self-citationWhite, P. J., Arita, M., Taguchi, R., Kang, J. X., & Marette, A. (2010) · Diabetes · doi:10.2337/db10-0054 · Cited by 185 · see citing works
Release of Prostaglandin from Rat Epididymal Fat Pad on Nervous and Hormonal Stimulation
Shaw, J. E., Ramwell, P. W., & Plasse, A. M. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93570-2 · Cited by 178 · see citing works
Spite, M. R., Hellmann, J. L., Tang, Y., Mathis, S., Kosuri, M., Bhatnagar, A., Jala, V. R., & Haribabu, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100196 · Cited by 177 · see citing works
Self-citationSerhan, C. N. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0695-8 · Cited by 175 · see citing works
Self-citationLi, S., Sun, Y., Liang, C., Thorp, E. B., Han, S., Jehle, A. W., Saraswathi, V., Pridgen, B. C., Kanter, J. E., Li, R., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.199570 · Cited by 168 · see citing works
Signalling role of adipose tissue: adipokines and inflammation in obesity
Wood, I. S., & Trayhurn, P. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051078 · Cited by 167 · see citing works
Phagocytosis of Apoptotic Cells by Macrophages From NOD Mice Is Reduced
O’Brien, B. A., Huang, Y., Geng, X., Dutz, J. P., & Finegood, D. T. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2481 · Cited by 162 · see citing works
Ko, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 159 · see citing works
Horrillo, R., González‐Périz, A., Martínez‐Clemente, M., López‐Parra, M., Ferré, N., Titos, E., Morán‐Salvador, E., Deulofeu, R., Arroyo, V., & Clària, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901355 · Cited by 152 · see citing works
Self-citationMetabolic Connections during Apoptotic Cell Engulfment
Han, C. Z., & Ravichandran, K. S. (2011) · Cell · doi:10.1016/j.cell.2011.12.006 · Cited by 144 · see citing works
Miyahara, T., Runge, S. J., Chatterjee, A., Chen, M., Mottola, G., Fitzgerald, J. M., Serhan, C. N., & Conte, M. S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225615 · Cited by 134 · see citing works
Self-citationLópez‐Vicario, C., González‐Périz, A., Rius, B., Morán‐Salvador, E., García‐Alonso, V., Lozano, J. J., Bataller, R. A., Cofán, M., Kang, J. X., Arroyo, V., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303179 · Cited by 133 · see citing works
Self-citationGyurko, R., Siqueira, C. C., Caldon, N., Gao, L., Kantarcı, A., & Dyke, T. E. V. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7250 · Cited by 132 · see citing works
Diversity of lipid mediators in human adipose tissue depots
Clària, J., Nguyen, B. T., Madenci, A. L., Ozaki, C. K., & Serhan, C. N. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00351.2012 · Cited by 130 · see citing works
Self-citationNon-alcoholic fatty liver disease: a massive problem
Thomas, H. C., & Day, C. P. (2011) · Clinical Medicine · doi:10.7861/clinmedicine.11-2-176 · Cited by 125 · see citing works
5-Lipoxygenase–Activating Protein
Bäck, M., Sultan, A., Овчинникова, О. А., & Hansson, G. K. (2007) · Circulation Research · doi:10.1161/01.res.0000264498.60702.0d · Cited by 119 · see citing works
Chiang, N., Shinohara, M., Dalli, J., Mirakaj, V., Kibi, M., Choi, A. M. K., & Serhan, C. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202969 · Cited by 117 · see citing works
Self-citationA deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse
O’Brien, B. A., Geng, X., Orteu, C. H., Huang, Y., Ghoreishi, M., Zhang, Y., Bush, J., Li, G., Finegood, D. T., & Dutz, J. P. (2006) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.11.006 · Cited by 115 · see citing works
Resolvin D 2 prevents secondary thrombosis and necrosis in a mouse burn wound model
Bohr, S., Patel, S. J., Sarin, D., Irimia, D., Yarmush, M. L., & Francois Berthiaume, B. (2012) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2012.00853.x · Cited by 114 · see citing works
Lipoxin A 4 attenuates adipose inflammation
Börgeson, E., McGillicuddy, F. C., Harford, K. A., Corrigan, N., Higgins, D. F., MADERNA, P., Roche, H. M., & Godson, C. (2012) · The FASEB Journal · doi:10.1096/fj.12-208249 · Cited by 114 · see citing works
Martínez‐Clemente, M., Ferré, N., González‐Périz, A., López‐Parra, M., Horrillo, R., Titos, E., Morán‐Salvador, E., Miquel, R., Arroyo, V., Funk, C. D., et al. (2009) · Hepatology · doi:10.1002/hep.23463 · Cited by 111 · see citing works
Self-citationProstaglandins, bioassay and inflammation
Flower, R. J. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706506 · Cited by 107 · see citing works
Chakrabarti, S. K., Wen, Y., Dobrian, A. D., Cole, B. K., Ma, Q., Pei, H., Williams, M. D., Bevard, M. H., Vandenhoff, G. E., Keller, S. R., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00203.2010 · Cited by 101 · see citing works
Hellmann, J. L., Zhang, M. J., Tang, Y., Rane, M. J., Bhatnagar, A., & Spite, M. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203369 · Cited by 93 · see citing works
Self-citationKöröskényi, K., Duró, E., Pallai, A., Sarang, Z., Kloor, D., Ucker, D. S., Beceiro, S., Castrillo, A., Chawla, A., Ledent, C. A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002284 · Cited by 83 · see citing works
Resolvin D2 restores neutrophil directionality and improves survival after burns
Kurihara, T., Jones, C. N., Yu, Y., Fischman, A. J., Watada, S., Tompkins, R. G., Fagan, S. P., & Irimia, D. (2013) · The FASEB Journal · doi:10.1096/fj.12-219519 · Cited by 81 · see citing works
Fat storage and the biology of energy expenditure
Redinger, R. N. (2009) · Translational research · doi:10.1016/j.trsl.2009.05.003 · Cited by 80 · see citing works
Koltsida, O., Karamnov, S., Pyrillou, K., Vickery, T. W., Chairakaki, A.-D., Tamvakopoulos, C., Sideras, P., Serhan, C. N., & Andreakos, E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201891 · Cited by 72 · see citing works
Self-citation12- and 15-lipoxygenases in adipose tissue inflammation
Cole, B. K., Lieb, D. C., Dobrian, A. D., & Nadler, J. L. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2012.07.004 · Cited by 66 · see citing works
Planagumà, A., Titos, E., López‐Parra, M., Gaya, J., Pueyo, G., Arroyo, V., & Clària, J. (2002) · The FASEB Journal · doi:10.1096/fj.02-0224fje · Cited by 59 · see citing works
Self-citationCanetti, C. D. A., Serezani, C. H., Atrasz, R. G., White, E. S., Aronoff, D. M., & Peters-Golden, M. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8350 · Cited by 50 · see citing works
Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A4
Titos, E., Chiang, N., Serhan, C. N., Romano, M., Gaya, J., Pueyo, G., & Clària, J. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.5.c870 · Cited by 50 · see citing works
Self-citationAttenuation of plasma annexin A1 in human obesity
Kosicka, A., Cunliffe, A., Mackenzie, R., Zariwala, M. G., Perretti, M., Flower, R. J., & Renshaw, D. W. (2012) · The FASEB Journal · doi:10.1096/fj.12-213728 · Cited by 45 · see citing works
Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis
Merched, A. J., Serhan, C. N., & Chan, L. (2011) · Lifestyle Genomics · doi:10.1159/000326890 · Cited by 40 · see citing works
Self-citationHodgson, K., Morris, J. L., Feterl, M., Govan, B., & Ketheesan, N. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.07.008 · Cited by 40 · see citing works
Acute and Chronic Inflammation
Ward, P. A. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9781139195737.002 · Cited by 37 · see citing works
Polymorphonuclear neutrophils and instability of the atherosclerotic plaque: a causative role?
Bona, R. D., Cardillo, M. T., Leo, M., Biasillo, G., Gustapane, M., Trotta, F., & Biasucci, L. M. (2013) · Inflammation Research · doi:10.1007/s00011-013-0617-0 · Cited by 30 · see citing works
Control of Myeloid Cell Trafficking in Resolution
Norling, L. V., & Perretti, M. (2013) · Journal of Innate Immunity · doi:10.1159/000350612 · Cited by 27 · see citing works
Alterations in Fc receptor function of macrophages from streptozotocin-induced diabetic rats.
Abrass, C. K., & Hori, M. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.3.1307 · Cited by 23 · see citing works
Jeppesen, J. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.110006 · Cited by 10 · see citing works
Links between Innate and Adaptive Immunity
Karp, C. L. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9781139195737.004 · Cited by 8 · see citing works
Resolution of Acute Inflammation and Wound Healing
Gilroy, D. W. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9781139195737.003 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Cassatella MA 2003 The Neutrophil Basel Karger
- Houck JC 1979 Chemical Messengers of the Inflammatory Process Amsterdam Elsevier/North-Holland Biomedical Press
Cited by
Sorted by citations
Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
Self-citationMozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
“Arachidonic acid, the prototypical metabolite of LA, is also commonly considered proinflammatory, but is also the natural precursor to specialized proresolving mediators of inflammation.(368,369) In prospective studies, higher biomarker levels of arachidonic acid are linked to significantly lower risk of CHD.”
Mammalian lipoxygenases and their biological relevance
Kühn, H., Banthiya, S., & van Leyen, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 629 · see citing works
The role of inflammation and genetics in periodontal disease
Loos, B. G., & Dyke, T. E. V. (2020) · Periodontology 2000 · doi:10.1111/prd.12297 · Cited by 637 · see citing works
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
Serhan, C. N., Chiang, N., & Dalli, J. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.004 · Cited by 583 · see citing works
Self-citationSerhan, C. N. (2017) · The FASEB Journal · doi:10.1096/fj.201601222r · Cited by 553 · see citing works
Self-citationInflammation and its Resolution as Determinants of Acute Coronary Syndromes
Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 523 · see citing works
Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
Hajishengallis, G., Chavakis, T., & Lambris, J. D. (2020) · Periodontology 2000 · doi:10.1111/prd.12331 · Cited by 513 · see citing works
Foundations of Immunometabolism and Implications for Metabolic Health and Disease
Hotamışlıgil, G. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.009 · Cited by 514 · see citing works
Ertunc, M. E., & Hotamışlıgil, G. S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066514 · Cited by 485 · see citing works
Invited review: Inflammation during the transition to lactation: New adventures with an old flame
Bradford, B. J., Yuan, K., Farney, J. K., Mamedova, L. K., & Carpenter, A. J. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9683 · Cited by 480 · see citing works
Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
Sonnweber, T., Pizzini, A., Nairz, M., Weiß, G., & Tancevski, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113285 · Cited by 439 · see citing works
Engelmann, C., Clària, J., Szabó, G., Bosch, J., & Bernardi, M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.01.002 · Cited by 407 · see citing works
Self-citationMicroglia mediate postoperative hippocampal inflammation and cognitive decline in mice
Feng, X., Valdearcos, M., Uchida, Y., Lutrin, D., Maze, M., & Koliwad, S. K. (2017) · JCI Insight · doi:10.1172/jci.insight.91229 · Cited by 361 · see citing works
Leoni, G., Neumann, P., Kamaly, N., Quirós, M., Nishio, H., Jones, H. R., Sumagin, R., Hilgarth, R., Alam, A. M., Fredman, G., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76693 · Cited by 355 · see citing works
Chiang, N., & Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.005 · Cited by 330 · see citing works
Self-citationOppedisano, F., Macrì, R., Gliozzi, M., Musolino, V., Carresi, C., Maiuolo, J., Bosco, F., Nucera, S., Zito, M. C., Guarnieri, L., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8090306 · Cited by 326 · see citing works
Targeting inflammation in metabolic syndrome
Welty, F. K., Alfaddagh, A., & Elajami, T. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.017 · Cited by 287 · see citing works
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Infante, M., Ricordi, C., Sanchez, J. E., Clare-Salzler, M. J., Padilla, N., Fuenmayor, V., Chavez, C., Alvarez, A., Baidal, D. A., Alejandro, R., et al. (2019) · Nutrients · doi:10.3390/nu11092185 · Cited by 275 · see citing works
The role of non-resolving inflammation in atherosclerosis
Kasikara, C., Doran, A. C., Cai, B., & Tabas, I. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97950 · Cited by 266 · see citing works
ESPEN guideline on clinical nutrition in hospitalized patients with acute or chronic kidney disease
Fiaccadori, E., Sabatino, A., Barazzoni, R., Carrero, J. J., Cupisti, A., De Waele, E., Jonckheer, J., Singer, P., & Cuerda, C. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.028 · Cited by 277 · see citing works
Activation and resolution of periodontal inflammation and its systemic impact
Hastürk, H., & Kantarcı, A. (2015) · Periodontology 2000 · doi:10.1111/prd.12105 · Cited by 240 · see citing works
Sansbury, B. E., & Spite, M. R. (2016) · Circulation Research · doi:10.1161/circresaha.116.307308 · Cited by 226 · see citing works
Self-citationLipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease
Börgeson, E., Johnson, A. M. F., Lee, Y. S., Till, A., Syed, G. H., Shah, S. T. A., Guiry, P. J., Dalli, J., Colas, R. A., Serhan, C. N., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.003 · Cited by 225 · see citing works
Self-citationStructural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)
Ivanov, I., Kühn, H., & Heydeck, D. (2015) · Gene · doi:10.1016/j.gene.2015.07.073 · Cited by 223 · see citing works
Lipid signaling in adipose tissue: Connecting inflammation & metabolism
Masoodi, M., Kuda, O., Rossmeisl, M., Flachs, P., & Kopecký, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.023 · Cited by 218 · see citing works
Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence
Zreik, N. H., Malik, R. A., & Charalambous, C. P. (2019) · Muscles Ligaments and Tendons Journal · doi:10.32098/mltj.01.2016.04 · Cited by 218 · see citing works
Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome
Martínez‐Fernández, L., Laiglesia, L. M., Huerta, A. E., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.07.003 · Cited by 208 · see citing works
The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders
Шрамко, В. С., Polonskaya, Y. V., Kashtanova, E. V., Stakhneva, E. M., & Ragino, Y. I. (2020) · Biomolecules · doi:10.3390/biom10081127 · Cited by 210 · see citing works
Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence
Nasri, H. Z. (2016) · Muscles Ligaments and Tendons Journal · doi:10.11138/mltj/2016.6.1.026 · Cited by 209 · see citing works
Schwarz, B. H., Sharma, L., Roberts, L. M., Peng, X., Bermejo, S. D., Leighton, I. A., Casanovas‐Massana, A., Minasyan, M., Farhadian, S., Ko, A. I., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2001025 · Cited by 205 · see citing works
Leiria, L. O., Wang, C., Lynes, M. D., Yang, K., Shamsi, F., Sato, M. M., Sugimoto, S., Chen, E. Y.-S., Bussberg, V., Narain, N. R., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.001 · Cited by 205 · see citing works
Self-citationOral infections and cardiovascular disease
Kholy, K. E., Genco, R. J., & Dyke, T. E. V. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.03.001 · Cited by 201 · see citing works
Yu, T., Gao, M., Yang, P., Liu, D., Wang, D., Song, F., Zhang, X., & Liu, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27185 · Cited by 183 · see citing works
Macrophage PPARγ and impaired wound healing in type 2 diabetes
Mirza, R. E., Fang, M. M., Novak, M. L., Urao, N., Sui, A., Ennis, W. J., & Koh, T. J. (2015) · The Journal of Pathology · doi:10.1002/path.4548 · Cited by 177 · see citing works
“Recently, pathways involved in the resolution of inflammation have garnered attention for their potential contribution to non-resolving inflammatory responses [4,5].”
BackgroundA twist of FATe: Lipid droplets and inflammatory lipid mediators
Jovičić, E. J., & Petan, T. (2019) · Biochimie · doi:10.1016/j.biochi.2019.11.016 · Cited by 177 · see citing works
Borow, K. M., Nelson, J. R., & Mason, R. P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.07.035 · Cited by 175 · see citing works
Regulation and Functions of 15-Lipoxygenases in Human Macrophages
Snodgrass, R. G., & Brüne, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00719 · Cited by 162 · see citing works
Dietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes
Wu, J. H. Y., Micha, R., & Mozaffarian, D. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0206-1 · Cited by 167 · see citing works
Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee
Xie, J., Huang, Z., Yu, X., Zhou, L., & Pei, F. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.03.004 · Cited by 164 · see citing works
Han, Y.-H., Shin, K.-O., Kim, J.-Y., Khadka, D. B., Kim, H.-J., Lee, Y.-M., Cho, W.-J., Cha, J.-Y., Lee, B.-J., & Lee, M.-O. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124219 · Cited by 154 · see citing works
Giannakis, N., Sansbury, B. E., Patsalos, A., Hays, T. T., Riley, C. O., Han, X., Spite, M. R., & Nagy, L. (2019) · Nature Immunology · doi:10.1038/s41590-019-0356-7 · Cited by 157 · see citing works
Self-citationAdipose tissue macrophages as potential targets for obesity and metabolic diseases
Li, X., Ren, Y., Chang, K.-W., Wu, W., Griffiths, H. R., Lu, S., & Gao, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1153915 · Cited by 165 · see citing works
Simonetto, M., Infante, M., Sacco, R. L., Rundek, T., & Della‐Morte, D. (2019) · Nutrients · doi:10.3390/nu11102279 · Cited by 156 · see citing works
Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome
Werner, M., Jordan, P. M., Romp, E., Czapka, A., Rao, Z., Kretzer, C., Koeberle, A., Garscha, U., Pace, S., Claesson, H., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802509r · Cited by 156 · see citing works
Self-citationEffects of Fish n-3 PUFAs on Intestinal Microbiota and Immune System
Parolini, C. (2019) · Marine Drugs · doi:10.3390/md17060374 · Cited by 154 · see citing works
Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study
Frediani, J. K., Jones, D. P., Tukvadze, N., Uppal, K., Sanikidze, E., Kipiani, M., Tran, V., Hebbar, G., Walker, D. I., Kempker, R. R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108854 · Cited by 151 · see citing works
Self-citationImmune and regulatory functions of neutrophils in inflammatory bone loss
Hajishengallis, G., Moutsopoulos, N. M., Hajishengallis, E., & Chavakis, T. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.02.002 · Cited by 146 · see citing works
The Adipocyte-Inducible Secreted Phospholipases PLA2G5 and PLA2G2E Play Distinct Roles in Obesity
Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.002 · Cited by 145 · see citing works
Insulin-sensitizing effects of omega-3 fatty acids: lost in translation?
Lalia, A., & Lanza, I. (2016) · Nutrients · doi:10.3390/nu8060329 · Cited by 141 · see citing works
Kosaraju, R., Guesdon, W., Crouch, M. J., Teague, H., Sullivan, E. M., Karlsson, E. A., Schultz‐Cherry, S., Gowdy, K. M., Bridges, L. C., Reese, L., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601031 · Cited by 136 · see citing works
Specialised pro-resolving mediators of inflammation in inflammatory arthritis
Barden, A. E., Moghaddami, M., Mas, E., Phillips, M. R., Cleland, L. G., & Mori, T. A. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.03.004 · Cited by 127 · see citing works
Desoyé, G., & Herrera, E. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101082 · Cited by 126 · see citing works
Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
Geng, K., Ma, X., Jiang, Z., Huang, W. G., Gao, C., Pu, Y., Luo, L., Xu, Y., & Xu, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653940 · Cited by 121 · see citing works
Maekawa, T., Hosur, K. B., Abe, T., Kantarcı, A., Ziogas, A., Wang, B., Dyke, T. E. V., Chavakis, T., & Hajishengallis, G. (2015) · Nature Communications · doi:10.1038/ncomms9272 · Cited by 121 · see citing works
Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis
Veselinović, M., Vasiljević, D., Vučić, V., Arsić, A., Petrović, S., Lucic, A. T., Savić, M., Živanović, S., Stojić, V., & Jakovljevic, V. L. (2017) · Nutrients · doi:10.3390/nu9040325 · Cited by 120 · see citing works
Gromovsky, A. D., Schugar, R. C., Brown, A. L., Helsley, R. N., Burrows, A. C., Ferguson, D., Zhang, R., Sansbury, B. E., Lee, R. G., Morton, R. E., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.309660 · Cited by 115 · see citing works
Self-citationLiu, Y., Chen, L., Sokołowska, M., Eberlein, M. H., Alsaaty, S., Martínez‐Antón, A., Logun, C., Qi, H., & Shelhamer, J. H. (2014) · Immunology · doi:10.1111/imm.12296 · Cited by 114 · see citing works
Kalinec, G. M., Lomberk, G. A., Urrutia, R. A., & Kalinec, F. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00192 · Cited by 115 · see citing works
López‐Vicario, C., Rius, B., Alcaraz‐Quiles, J., García‐Alonso, V., Lopategi, A., Titos, E., & Clària, J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.092 · Cited by 112 · see citing works
Self-citationDocosahexaenoic acid, 22:6n‐3: Its roles in the structure and function of the brain
Mallick, R., Basak, S., & Duttaroy, A. K. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.10.004 · Cited by 113 · see citing works
Bioactive products formed in humans from fish oils
Skarke, C., Alamuddin, N., Lawson, J. A., Li, X., Ferguson, J. F., Reilly, M. P., & FitzGerald, G. A. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m060392 · Cited by 109 · see citing works
Bioactive metabolites of docosahexaenoic acid
Kuda, O. (2017) · Biochimie · doi:10.1016/j.biochi.2017.01.002 · Cited by 112 · see citing works
Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation
Zhang, M. J., Sansbury, B. E., Hellmann, J. L., Baker, J. F., Guo, L., Parmer, C. M., Prenner, J. C., Conklin, D. J., Bhatnagar, A., Creager, M. A., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.021894 · Cited by 108 · see citing works
Self-citationSignaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue
Titos, E., Rius, B., López‐Vicario, C., Alcaraz‐Quiles, J., García‐Alonso, V., Lopategi, A., Dalli, J., Lozano, J. J., Arroyo, V., Delgado, S., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502522 · Cited by 106 · see citing works
Self-citationZaloga, G. P. (2021) · Nutrients · doi:10.3390/nu13020662 · Cited by 106 · see citing works
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation
Sugimoto, S., Mena, H. A., Sansbury, B. E., Kobayashi, S., Tsuji, T., Wang, C., Yin, X., Huang, T. L., Kusuyama, J., Kodani, S. D., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00590-0 · Cited by 106 · see citing works
Self-citationMartínez‐Fernández, L., González‐Muniesa, P., Laiglesia, L. M., Sáinź, N., Prieto-Hontoria, P. L., Escoté, X., Odriozola, L., Corrales, F. J., Arbonés-Mainar, J. M., Martínez, J. A., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201600859r · Cited by 104 · see citing works
Huang, C., Chien, Y.-S., Chen, Y.-J., Ajuwon, K. M., Mersmann, H. J., & Ding, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101689 · Cited by 101 · see citing works
Specialized pro-resolving mediators in cardiovascular diseases
Fredman, G., & Spite, M. R. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.02.003 · Cited by 98 · see citing works
Self-citationPoisson, L., Suhail, H., Singh, J., Datta, I., Đenić, A., Łabuzek, K., Hoda, M. N., Shankar, A., Kumar, A., Cerghet, M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.679068 · Cited by 94 · see citing works
Liu, T., Xiang, A., Peng, T., Doran, A. C., Tracey, K. J., Barnes, B. J., Tabas, I. A., Son, M., & Diamond, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907490116 · Cited by 93 · see citing works
Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis
Brennan, E. P., Mohan, M., McClelland, A., de Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., et al. (2018) · Diabetes · doi:10.2337/db17-1317 · Cited by 92 · see citing works
Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseases
Sottero, B., Rossin, D., Poli, G., & Biasi, F. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170619104105 · Cited by 89 · see citing works
Sears, B. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1080105 · Cited by 89 · see citing works
Lee, Y.-H., Kim, S.-N., Kwon, H.-J., Maddipati, K. R., & Granneman, J. G. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00355.2015 · Cited by 88 · see citing works
Tang, S. J., Wan, M., Huang, W. G., Stanton, R. C., & Xu, Y. (2018) · Mediators of Inflammation · doi:10.1155/2018/2380319 · Cited by 88 · see citing works
Shevalye, H., Yorek, M. S., Coppey, L. J., Holmes, A. J., Harper, M. M., Kardon, R. H., & Yorek, M. A. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00224.2015 · Cited by 85 · see citing works
Video display terminal use and dry eye: preventive measures and future perspectives
Kamøy, B., Magnø, M. S., Nøland, S. T., Moe, M. C., Petrovski, G., Vehof, J., & Utheim, T. P. (2022) · Acta Ophthalmologica · doi:10.1111/aos.15105 · Cited by 82 · see citing works
Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention
Umar, A., Steele, V. E., Menter, D. G., & Hawk, E. T. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.09.010 · Cited by 81 · see citing works
Bioactive Lipids and Their Derivatives in Biomedical Applications
Park, J.-W., Choi, J., Kim, D., Lee, S., Lee, B., Lee, Y., Kim, S., Kwon, S., Noh, M., Lee, M., et al. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.107 · Cited by 79 · see citing works
Kim, M., Yang, D., Kim, M., Kim, S., Kim, D., & Kang, S. (2017) · Scientific Reports · doi:10.1038/srep39804 · Cited by 79 · see citing works
Qian, F., Korat, A. V. A., Imamura, F., Marklund, M., Tintle, N., Virtanen, J. K., Zhou, X., Bassett, J. K., Lai, H. T. M., Hirakawa, Y., et al. (2021) · Diabetes Care · doi:10.2337/dc20-2426 · Cited by 82 · see citing works
Rodríguez, M. J., Sabaj, M., Tolosa, G., Vielma, F. H., Zúñiga, M. J., González, D. R., & Zúñiga‐Hernández, J. (2021) · Cells · doi:10.3390/cells10123406 · Cited by 78 · see citing works
Bae, J. H., Lim, H., & Lim, S. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.03.014 · Cited by 78 · see citing works
Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction
Lopategi, A., López‐Vicario, C., Alcaraz‐Quiles, J., García‐Alonso, V., Rius, B., Titos, E., & Clària, J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.033 · Cited by 79 · see citing works
Self-citationn-3 Fatty acid supplementation and proresolving mediators of inflammation
Barden, A. E., Mas, E., & Mori, T. A. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000262 · Cited by 77 · see citing works
ω-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye
Walter, S. D., Gronert, K., McClellan, A. L., Levitt, R. C., Sarantopoulos, K. D., & Galor, A. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19131 · Cited by 76 · see citing works
Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1
Balta, M. G., Loos, B. G., & Nicu, E. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01682 · Cited by 76 · see citing works
Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells
Markworth, J. F., Brown, L. A., Lim, E. Y., Floyd, C., Larouche, J. A., Castor‐Macias, J. A., Sugg, K. B., Sarver, D. C., Macpherson, P. C. D., Davis, C. S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137713 · Cited by 75 · see citing works
Hiram, R., Xiong, F., Naud, P., Xiao, J., Sirois, M. G., Tanguay, J., Tardif, J., & Nattel, S. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa186 · Cited by 74 · see citing works
Mas, E., Barden, A. E., Burke, V., Beilin, L. J., Watts, G. F., Huang, R., Puddey, I. B., Irish, A. B., & Mori, T. A. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.04.004 · Cited by 73 · see citing works
Field, R., Pourkazemi, F., Turton, J. L., & Rooney, K. B. (2020) · Pain Medicine · doi:10.1093/pm/pnaa378 · Cited by 73 · see citing works
Fiala, M., Halder, R. C., Sagong, B., Ross, O., Sayre, J. W., Porter, V. R., & Bredesen, D. E. (2015) · The FASEB Journal · doi:10.1096/fj.14-264218 · Cited by 72 · see citing works
Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease
Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R. J., Tan, S. M., Shah, S. T. A., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017101112 · Cited by 71 · see citing works
Role of neutrophils in ischemic heart failure
Kain, V., & Halade, G. V. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107424 · Cited by 76 · see citing works
Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation
Kilburg-Basnyat, B. J., Reece, S. W., Crouch, M. J., Luo, B., Boone, A. D., Yaeger, M. J., Hodge, M. X., Psaltis, C. E., Hannan, J. L., Manke, J., et al. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy040 · Cited by 71 · see citing works
Körner, A., Zhou, E., Müller, C., Mohammed, Y., Herceg, S., Bracher, F., Rensen, P. C. N., Wang, Y., Mirakaj, V., & Giera, M. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911992116 · Cited by 70 · see citing works
De Novo Lipogenesis Products and Endogenous Lipokines
Yilmaz, M., Claiborn, K. C., & Hotamışlıgil, G. S. (2016) · Diabetes · doi:10.2337/db16-0251 · Cited by 70 · see citing works
Rius, B., Duran‐Güell, M., Flores‐Costa, R., López‐Vicario, C., Lopategi, A., Alcaraz‐Quiles, J., Casulleras, M., Lozano, J. J., Titos, E., & Clària, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700394r · Cited by 69 · see citing works
Self-citation
- Authors
- Spite, M., Clària, J., & Serhan, C. N.
- Affiliations
- University of Louisville (US)
- Hospital Clínic de Barcelona (ES)
- Brigham and Women's Hospital (US)
- Corresponding author
- Serhan, Charles N.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 19
- Issue
- 1
- Pages
- 21-36
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3947989
- OpenAlex
- W2065295548
- Cited by
- 464
- References
- 130
- Citations by year
- 2026: 37 · 2025: 28 · 2024: 20 · 2023: 23 · 2022: 33 · 2021: 49 · 2020: 43 · 2019: 53 · 2018: 27 · 2017: 47 · 2016: 35 · 2015: 48 · 2014: 20
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (4r37gm038765-19)
- National Heart, Lung, and Blood Institute (HL-106173, R01HL106173)
- National Institute of General Medical Sciences (P20GM103492, P01GM095467, GM-095467, GM 103492, GM038765, R01GM038765, R37-GM038765)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- resolvins, protectins, maresins, inflammation resolution, low-grade inflammation, metabolic disorders, tissue regeneration, neutrophil recruitment, autacoids
- MeSH terms
- Animals, Fatty Acids, Unsaturated, Humans, Inflammation, Metabolic Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review