The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Comparison of Conventional and Split-Course Radiotherapy as Primary Treatment in Carcinoma of the Larynx
Open accessAbstract
Based on our experience with conventional, daily irradiation, a split-course radiation schedule was introduced in 1978. The schedule, which was based on Cohen's models for squamous cell carcinoma and vascular damage respectively, predicted an improved tumour control and a reduced rate of late complications, e.g. late oedema, if the conventional, daily treatment was replaced by a split-course schedule. The schedule has later been abandoned, but the experience gained from split-course treatment at various dose levels has been analysed and the results compared with those obtained by conventional radiation. The data allowed construction of dose-response curves and estimation of iso-effect doses. Split-course treatment was associated with a significantly reduced therapeutic ratio because, disappointingly, it did not improve tumour control, and the severity of late complications grew. No late complications were avoided by introducing a 3-week pause in the radiation therapy regimen, nor was the tumour response improved despite a 12-Gy increase in total dose. This indicates a significant repopulation corresponding to more than 0.5 Gy/day, equivalent to an up to 100-fold increase of the number of clonogenic tumour cells during the pause--an increase that occurred despite the decrease, clinically, of the tumours during this period.
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Citations
Cites
The hazard of accelerated tumor clonogen repopulation during radiotherapy
Withers, H. R., Taylor, J. M. G., & Maciejewski, B. (1988) · Acta Oncologica · doi:10.3109/02841868809090333 · Cited by 1,601
Accelerated fractionation vs hyperfractionation: Rationales for several treatments per day
Thames, H. D., Peters, L. T., Withers, H. R., & Fletcher, G. H. (1983) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(83)90089-5 · Cited by 415
Maciejewski, B., Preuss-Bayer, G., & Trott, K.-R. (1983) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(83)90290-0 · Cited by 284
A re-evaluation of split-course technique for squamous cell carcinoma of the head and neck
Parsons, J. T., Bova, F. J., & Million, R. R. (1980) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(80)90246-1 · Cited by 257
Overgaard, J., Sand Hansen, H., Jøsrgensen, K., & Hjelm Hansen, M. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90058-1 · Cited by 239
Self-citationCell Kinetics and Radiation Biology
Denekamp, J. (1986) · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine · doi:10.1080/09553008514552591 · Cited by 177
What Next in Fractionated Radiotherapy?
Herbert, D. E. (1987) · Investigative Radiology · doi:10.1097/00004424-198705000-00018 · Cited by 106
Biophysical Models in Radiation Oncology
Wheldon, T. E. (1983) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008314551721 · Cited by 32
Biophysical Models In Radiation Oncology
Cohen, L. (1982) · Cited by 25
Cited by
Overgaard, J., Sand Hansen, H., Overgaard, M., Bastholt, L., Berthelsen, A., Specht, L., Lindeløv, B., & Jørgensen, K. (1998) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(97)00220-x · Cited by 573
Self-citationBese, N. S., Hendry, J., & Jeremic, B. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.03.010 · Cited by 382
Lanciano, R. M., Pajak, T. F., Martz, K., & Hanks, G. E. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90058-4 · Cited by 334
Robertson, C., Robertson, A. G., Hendry, J. H., Roberts, S. A., Slevin, N. J., Duncan, W. B., MacDougall, R. H., Kerr, G. R., O'Sullivan, B., & Keane, T. J. (1998) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(97)00716-5 · Cited by 154
Metadata
- Authors
- Overgaard, J., Hjelm-Hansen, M., Johansen, L. V., & Andersen, A. P.
- Venue
- Acta Oncologica
- Published
- 1988-01
- Volume
- 27
- Issue
- 2
- Pages
- 147-152
- ISSN
- 0284-186X (ISSN-L)
- 1651-226X
- OpenAlex
- W2090896110
- Cited by
- 256
- References
- 9
- FWCI
- 19.25
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Overgaard, J., Hjelm-Hansen, M., Johansen, L. V., & Andersen, A. P. (1988). Comparison of Conventional and Split-Course Radiotherapy as Primary Treatment in Carcinoma of the Larynx. Acta Oncologica. https://doi.org/10.3109/02841868809090334
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
