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Analysis of the Effects of Oxygen Supply and Demand on Hypoxic Fraction in Tumors
Open accessAbstract
The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consumption on hypoxic fraction are simulated theoretically, for a region whose microvascular geometry was derived from observations of a transplanted mammary andenocarcinoma (R3230AC) in a rat dorsal skin flap preparation. In the control state, arterial PO2 is 100 mmHg, consumption rate is 2.4 cm3 O2/100 g/min, and hypoxic fraction (tissue with PO2 < 3 mmHg) is 30%. Hypoxia is abolished by a reduction in consumption rate of at least 30%, relative to control, or an increase in flow rate by a factor of 4 or more, or an increase in arterial PO2 by a factor of 11 or more. These results suggest that reducing oxygen consumption rate may be more effective than elevating blood flow or oxygen content as a method to reduce tumor hypoxia.
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Cites
Hyperbaric oxygen: the Medical Research Council trials and their clinical significance
Dische, S. (1978) · The British Journal of Radiology · doi:10.1259/0007-1285-51-611-888 · Cited by 154
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Chen, Z., Han, F., Du, Y., Shi, H., & Zhou, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01332-8 · Cited by 1,612
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022
Self-citationConquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Metadata
- Authors
- Secomb, T. W., Hsu, R., Ong, E. T., Gross, J. F., & Dewhirst, M. W.
- Venue
- Acta Oncologica
- Published
- 1995-01
- Volume
- 34
- Issue
- 3
- Pages
- 313-316
- ISSN
- 0284-186X (ISSN-L)
- 1651-226X
- OpenAlex
- W2073399837
- Cited by
- 276
- References
- 1
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Analysis of the Effects of Oxygen Supply and Demand on Hypoxic Fraction in Tumors. https://app.cochat.ai/papers/10.3109/02841869509093981
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- Secomb, T. W., Hsu, R., Ong, E. T., Gross, J. F., & Dewhirst, M. W. (1995). Analysis of the Effects of Oxygen Supply and Demand on Hypoxic Fraction in Tumors. Acta Oncologica. https://doi.org/10.3109/02841869509093981
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
