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Collagen Cross-Linking Alterations in Joint Contractures: Changes in the Reducible Cross-Links in Periarticular Connective Tissue Collagen After Nine Weeks of Immobilization
Abstract
A significant increase in the NaBH4 reducible intermolecular cross-links in the 9 week immobilized rabbit periarticular connective tissue was found. Dihydroxylysinonorleucine, hydroxylysinonorleucine, and histidinohydroxymerodesmosine were the major cross-links which increased during the period of immobilization. No change in the hydroxlysine/lysine ratio between the immobilized and control periarticular connective tissue collagen was detected during the 9 weeks of enforced immobilization of the rabbit knee. Since the collagen mass in the immobilized periarticular connective tissue does not change, or at most is reduced 10%, we suggest that there is an increase in collagen cross-links expressed both in per unit weight of collagen and on the basis of collagen mass per knee due to the lack of physical stress and motion.
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Citations
Cited by
TENDON INJURY AND TENDINOPATHY: HEALING AND REPAIR
SHARMA, P., & MAFFULLI, N. (2005) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200501000-00030 · Cited by 1,074
Tendons and ligaments: A morphological and biochemical comparison
Amiel, D., Frank, C., Harwood, F., Fronek, J., & Akeson, W. (1983) · Journal of Orthopaedic Research · doi:10.1002/jor.1100010305 · Cited by 607
Self-citationMedial collateral ligament healing: A multidisciplinary assessment in rabbits
Frank, C., Woo, S. L.-Y., Amiel, D., Harwood, F., Gomez, M., & Akeson, W. (1983) · The American Journal of Sports Medicine · doi:10.1177/036354658301100602 · Cited by 367
Self-citationSarrigiannidis, S. O., Rey, J. M., Dobre, O., González-García, C., Dalby, M. J., & Salmeron-Sanchez, M. (2021) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100098 · Cited by 309
Collagen: Structure, function, and metabolism in normal and fibrotic tissues
Nimni, M. E. (1983) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(83)90024-0 · Cited by 266
Metadata
- Authors
- Akeson, W. H., Amiel, D., Mechanic, G. L., Woo, S. L.-Y., Harwood, F. L., & Hamer, M. L.
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 1977-01
- Volume
- 5
- Issue
- 1
- Pages
- 15-19
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2155280674
- Cited by
- 185
- References
- 0
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Collagen Cross-Linking Alterations in Joint Contractures: Changes in the Reducible Cross-Links in Periarticular Connective Tissue Collagen After Nine Weeks of Immobilization. https://app.cochat.ai/papers/10.3109/03008207709152607
- The paper
- Akeson, W. H., Amiel, D., Mechanic, G. L., Woo, S. L.-Y., Harwood, F. L., & Hamer, M. L. (1977). Collagen Cross-Linking Alterations in Joint Contractures: Changes in the Reducible Cross-Links in Periarticular Connective Tissue Collagen After Nine Weeks of Immobilization. Connective Tissue Research. https://doi.org/10.3109/03008207709152607
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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