Primed Mesenchymal Stem Cells Alter and Improve Rat Medial Collateral Ligament Healing
Open accessAbstract
Cell therapy with mesenchymal stem cells (MSCs) can improve tissue healing. It is possible, however, that priming MSCs prior to implantation can further enhance their therapeutic benefit. This study was then performed to test whether priming MSCs to be more anti-inflammatory would enhance healing in a rat ligament model, i.e. a medial collateral ligament (MCL). MSCs were primed for 48 h using polyinosinic acid and polycytidylic acid (Poly (I:C)) at a concentration of 1 μg/ml. Rat MCLs were surgically transected and administered 1 × 10(6) cells in a carrier solution at the time of injury. A series of healing metrics were analyzed at days 4 and 14 post-injury in the ligaments that received primed MSCs, unprimed MSCs, or no cells (controls). Applying primed MSCs beneficially altered healing by affecting endothelialization, type 2 macrophage presence, apoptosis, procollagen 1α, and IL-1Ra levels. When analyzing MSC localization, both primed and unprimed MSCs co-localized with endothelial cells and pericytes suggesting a supportive role in angiogenesis. Priming MSCs prior to implantation altered key ligament healing events, resulted in a more anti-inflammatory environment, and improved healing.
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Primed MSCs create a more anti-inflammatory environment in the MCL healing process.
“Increased early endothelization, a higher number of M2 macrophages, interleukin-1 receptor antagonists, and procollagen 1a levels were observed compared with other groups, suggesting a more anti-inflammatory environment in the MCL healing process.”
From Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint (2023) · cites this paper as [65]
Both primed and unprimed MSCs co-localize with endothelial cells and pericytes, implying a supportive role in angiogenesis during the healing process.
“Furthermore, both primed and unprimed MSCs co-localized with endothelial cells and pericytes, implying a supportive role in angiogenesis during the healing process.”
From Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint (2023) · cites this paper as [65]
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- Authors
- Saether, E. E., Chamberlain, C. S., Aktas, E., Leiferman, E. M., Brickson, S. L., & Vanderby, R.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Vanderby, Ray
- Venue
- Stem Cell Reviews and Reports
- Published
- 2015-11-04
- Volume
- 12
- Issue
- 1
- Pages
- 42-53
- ISSN
- 1550-8943 (ISSN-L)
- 1558-6804
- PMC
- PMC4968884
- OpenAlex
- W2279938184
- Cited by
- 34
- References
- 36
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Stem Cell Reviews and Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR059916)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, cell priming, medial collateral ligament, ligament healing, poly(I:C), angiogenesis, M2 macrophages, apoptosis, interleukin-1 receptor antagonist, endothelialization, pericytes, cell therapy
- MeSH terms
- Collagen Type I, alpha 1 Chain, Animals, Cell Movement, Humans, Macrophages, Male, Poly I-C, Wound Healing, Rats, Wistar, Apoptosis, Collateral Ligaments, Neovascularization, Physiologic, Pericytes, Collagen Type I, Endothelial Cells, Mesenchymal Stem Cell Transplantation, Rats, Interleukin 1 Receptor Antagonist Protein, Mesenchymal Stem Cells, Primary Cell Culture
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