Altered autonomic function in patients with arthritis or with chronic myofascial pain
Abstract
Dynamic autonomic function tests (pupillary light reflex, Valsalva maneuver, and mental arithmetic) were used to evaluate autonomic function (pupil size, heart rate, and skin conductance) in patients with inflammatory arthritis or with chronic myofascial pain. Physiological responses in both groups of patients suggest concurrent increases in tonic pupillary autonomic activity (sympathetic and parasympathetic), with a relative sympathetic dominance, and a decrease in tonic parasympathetic cardiovascular activity. Furthermore, in the arthritis group, the data suggest decreased cardiovascular parasympathetic reaction and enhanced sudomotor reaction.
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Some studies have indicated that patients with chronic inflammatory diseases have an increased activity of the sympathetic nervous system.
“Some studies have indicated that patients with chronic inflammatory diseases have an increased activity of the SNS.”
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- Authors
- Perry, F., Heller, P. H., Kamiya, J., & Levine, J. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Levine, Jon D.
- ORCID
- Levine, Jon D.
- Venue
- Pain
- Published
- 1989-10
- Volume
- 39
- Issue
- 1
- Pages
- 77-84
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2023050693
- Cited by
- 102
- References
- 44
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am032634-03)
- Medical Research Council
- National Institute of Neurological Disorders and Stroke (NS21647)
- National Institute of Dental and Craniofacial Research (DEO5369)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- autonomic function, inflammatory arthritis, chronic myofascial pain, pupillary light reflex, Valsalva maneuver, mental arithmetic, skin conductance, heart rate, sympathetic dominance, parasympathetic activity
- MeSH terms
- Arthritis, Autonomic Nervous System, Cardiovascular System, Chronic Disease, Galvanic Skin Response, Humans, Myofascial Pain Syndromes, Pupil
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