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Cited by 8Digestive system and related healthCeliac Disease Research and ManagementGenetic Associations and Epidemiology

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Lactase genetic polymorphisms and coeliac disease in children: a cohort study

Kuchay, Raja A. H., Thapa, Babu R., Mahmood, Akhtar, Anwar, Mumtaz, Mahmood, Safrun·2015·Annals of Human Biology
DOI 10.3109/03014460.2014.944216
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Abstract

Background Lactase activity declines during childhood in the majority of human populations leading to adult-type hypolactasia (AtH). C/T-13910 and G/A-22018 single nucleotide polymorphisms (SNPs) have been suggested to be associated with AtH in different human populations. Coeliac disease (CD) is an autoimmune condition characterized by damage to intestinal cells leading to ultimate deterioration. Aim This study investigated the association between coeliac disease (CD) and SNPs leading to AtH in children from North India. Subjects and methods Intestinal biopsies and saliva samples were obtained from 52 children with CD diagnosis and 102 control subjects. Biopsies were assayed for disaccharidase activities and samples were genotyped for given SNPs. Results Prevalence of C/C and G/G genotypes of AtH was almost equal in the CD and control group. The CD group had low lactase activity compared to the control group, irrespective of genotype at C/T -13910 and G/A -22018 SNPs (p Conclusion There appears to be no significant correlation between C/T -13910 or G/A -22018 SNPs of AtH and CD. Children with C/C or G/G genotype of AtH may not be at greater risk of CD.

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Metadata

Authors
Kuchay, R. A. H., Thapa, B. R., Mahmood, A., Anwar, M., & Mahmood, S.
Affiliations
  • Post Graduate Institute of Medical Education and Research (IN)
  • Panjab University (IN)
Corresponding author
Mahmood, Safrun
ORCID
Venue
Annals of Human Biology
Publisher
Informa UK Limited
Published
2014-08-13
Volume
42
Issue
1
Pages
101-104
ISSN
  • 0301-4460 (ISSN-L)
  • 1464-5033
DOI
10.3109/03014460.2014.944216
OpenAlex
W2020106804
Cited by
8
References
0
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Human Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Postgraduate Institute of Medical Education and Research, Chandigarh
  • Department of Biotechnology, Ministry of Science and Technology, India
Topics
  • Health Sciences › Medicine › Gastroenterology › Digestive system and related health
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
celiac disease, adult-type hypolactasia, single nucleotide polymorphisms, lactase activity, disaccharidase activity, children, North India
MeSH terms
Celiac Disease, Child, Child, Preschool, Genotype, Humans, India, Lactose Intolerance, Cohort Studies, Polymorphism, Single Nucleotide, Lactase

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