Cited by 24Inhalation and Respiratory Drug DeliveryAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

Targeted drug delivery of Rifampicin to the lungs: formulation, characterization, and stability studies of preformed aerosolized liposome and in situ formed aerosolized liposome

Gaur, Praveen Kumar, Mishra, Shikha, Gupta, Vipin Bihari, Rathod, Mahendra Singh, Purohit, Suresh, Savla, Bhavin A.·2010·Drug Development and Industrial Pharmacy

Abstract

PURPOSE: This study aimed at the preparation and characterization of preformed and in situ formed liposomes for sustained delivery to the lungs. METHODS: Two different liposome formulations were prepared and subjected to characterization of physical parameters and drug release profile (% cumulative drug release and % drug retained). Formulations were then subjected to accelerated stability studies as per ICH guidelines. RESULTS: In situ formed liposome showed better sustained release profile than the preformed liposome as it released sufficient amount of drug while retaining considerable amount of drug. Upon subjection to accelerated conditions for 60 days, preformed liposome lost the objective of being controlled release formulation.

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Crossref · 10.3109/03639040903410300

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44 of 44 references verified0 citation errors · 0 not checkable

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  • RIF encapsulated in liposomes made of PC and cholesterol as aerosols showed a sustained release profile with an encapsulation efficiency of ~30%.

    “In another study, RIF encapsulated in liposomes (made of PC and Chol) as aerosols showed a sustained release profile with an encapsulation efficiency of ~30%.210”

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Authors
Gaur, P. K., Mishra, S., Gupta, V. B., Rathod, M. S., Purohit, S., & Savla, B. A.
Affiliations
Mandsaur University (IN)
Corresponding author
Gaur, Praveen Kumar
Venue
Drug Development and Industrial Pharmacy
Published
2010-02-06
Volume
36
Issue
6
Pages
638-646
ISSN
  • 0363-9045 (ISSN-L)
  • 1520-5762
OpenAlex
W2154718337
Cited by
24
References
44
Citations by year
2025: 1 · 2024: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 4 · 2013: 4 · 2012: 2
FWCI
2.39
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Development and Industrial Pharmacy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
rifampicin, pulmonary drug delivery, sustained drug release, liposome stability, accelerated stability testing, drug retention
MeSH terms
Aerosols, Animals, Chemistry, Pharmaceutical, Drug Stability, Liposomes, Lung, Rifampin, Drug Delivery Systems, Rats

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