Targeted drug delivery of Rifampicin to the lungs: formulation, characterization, and stability studies of preformed aerosolized liposome and in situ formed aerosolized liposome
Abstract
PURPOSE: This study aimed at the preparation and characterization of preformed and in situ formed liposomes for sustained delivery to the lungs. METHODS: Two different liposome formulations were prepared and subjected to characterization of physical parameters and drug release profile (% cumulative drug release and % drug retained). Formulations were then subjected to accelerated stability studies as per ICH guidelines. RESULTS: In situ formed liposome showed better sustained release profile than the preformed liposome as it released sufficient amount of drug while retaining considerable amount of drug. Upon subjection to accelerated conditions for 60 days, preformed liposome lost the objective of being controlled release formulation.
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RIF encapsulated in liposomes made of PC and cholesterol as aerosols showed a sustained release profile with an encapsulation efficiency of ~30%.
“In another study, RIF encapsulated in liposomes (made of PC and Chol) as aerosols showed a sustained release profile with an encapsulation efficiency of ~30%.210”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [210]
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
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- Authors
- Gaur, P. K., Mishra, S., Gupta, V. B., Rathod, M. S., Purohit, S., & Savla, B. A.
- Affiliations
- Mandsaur University (IN)
- Corresponding author
- Gaur, Praveen Kumar
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 2010-02-06
- Volume
- 36
- Issue
- 6
- Pages
- 638-646
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2154718337
- Cited by
- 24
- References
- 44
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- rifampicin, pulmonary drug delivery, sustained drug release, liposome stability, accelerated stability testing, drug retention
- MeSH terms
- Aerosols, Animals, Chemistry, Pharmaceutical, Drug Stability, Liposomes, Lung, Rifampin, Drug Delivery Systems, Rats
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