Cited by 123Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryTuberculosis Research and Epidemiology

The formulation of nanomedicines for treating tuberculosis

Costa, Ana, Pinheiro, Marina, Magalhães, Joana, Ribeiro, Ricardo, Seabra, Vitor, Reis, Salette, Sarmento, Bruno·2016·Advanced Drug Delivery Reviews

Abstract

Recent estimates indicate that tuberculosis (TB) is the leading cause of death worldwide, alongside the human immunodeficiency virus (HIV) infection. The current treatment is effective, but is associated with severe adverse-effects and noncompliance to prescribed regimens. An alternative route of drug delivery may improve the performance of existing drugs, which may have a key importance in TB control and eradication. Recent advances and emerging technologies in nanoscale systems, particularly nanoparticles (NPs), have the potential to transform such approach to human health and disease. Until now, several nanodelivery systems for the pulmonary administration of anti-TB drugs have been intensively studied and their utility as an alternative to the classical TB treatment has been suggested. In this context, this review provides a comprehensive analysis of recent progress in nanodelivery systems for pulmonary administration of anti-TB drugs. Additionally, more convenient and cost-effective alternatives for the lung delivery, different types of NPs for oral and topical are also being considered, and summarized in this review. Lastly, the future of this growing field and its potential impact will be discussed.

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Crossref · 10.1016/j.addr.2016.04.012

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Authors
Costa, A., Pinheiro, M., Magalhães, J., Ribeiro, R., Seabra, V., Reis, S., & Sarmento, B.
Affiliations
Universidade do Porto (PT)
Corresponding author
Sarmento, Bruno
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2016-07
Volume
102
Pages
102-115
ISSN
0169-409X (ISSN-L)
OpenAlex
W2337917444
Cited by
123
References
155
Citations by year
2026: 6 · 2025: 13 · 2024: 16 · 2023: 10 · 2022: 19 · 2021: 19 · 2020: 14 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 1
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • FCT (Fundação para a Ciência e Tecnologia) (SFRH/BD/95227/2013, SFRH/BPD/99124/2013, PD/BI/105907/2014)
  • European Regional Development Fund (ERDF)
  • North Portugal Regional Operational Programme
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Keywords
tuberculosis, nanomedicine, nanoparticle drug delivery, nanoparticles, pulmonary drug delivery, antitubercular agents, oral drug delivery, topical drug delivery, drug formulation, medication adherence, adverse drug reactions
MeSH terms
Antitubercular Agents, Chemistry, Pharmaceutical, Humans, Tuberculosis, Drug Delivery Systems, Nanomedicine

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