Physicochemical study on microencapsulation of hydroxypropyl-β-cyclodextrin in dermal preparations
Abstract
Objective To investigate the effect of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) concentration on the physicochemical properties of the sunscreen agents, namely oxybenzone (Oxy), octocrylene (Oct), and ethylhexyl-methoxy-cinnamate (Cin), in aqueous solution and cream formulations. Methods The inclusion complexes of sunscreen agents with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in aqueous solution and solid phase were studied by UV-vis spectrophotmetery, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and 13C-NMR techniques. The photodegradation reaction of the sunscreen agents' molecules in lotion was explored using UV-vis spectrophotometry and high-performance liquid chromatography (HPLC). Results The formation of the inclusion complexes was confirmed experimentally using DSC, SEM, and 13C-NMR. The results of spectrophotometric and HPLC studies have shown that the inclusion complexation with HP-beta-CD has the potential to enhance the photostability of the selected sunscreen agents in lotion. HPLC results indicated that HP-beta-CD has approximately increases the photostability of Oct by six- to eightfold. Moreover, the presence of HP-beta-CD in lotion controlled the isomerization process of Cin to a certain degree, which was found to be a function of the amount of HP-beta-CD added. Conclusions It has been demonstrated that the photostability of the tested sunscreen agents has been enhanced upon forming inclusion complexes with HP-beta-CD i…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Micro-encapsulation of oxybenzone, EHMC, and octocrylene in hydroxypropyl-β-cyclodextrins acts as photostabilisers.
“Al-Rawashdeh et al. (2010) reported the micro-encapsulation of commercial UV filters (oxybenzone (10), EHMC (21), and octocrylene (30)) in hydroxypropyl-β-cyclodextrins system that successfully acted as photostabilisers [44].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [44]
Cites
Introduction and General Overview of Cyclodextrin Chemistry
Szejtli, J. (1998) · Chemical Reviews · doi:10.1021/cr970022c · Cited by 5,016 · see citing works
Handbook of Pharmaceutical Excipients
Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (1994) · Cited by 3,501 · see citing works
Bender, M. L., & Komiyama, M. (1978) · Reactivity and structure · doi:10.1007/978-3-642-66842-5 · Cited by 1,902 · see citing works
Cyclodextrins and their pharmaceutical applications
Loftsson, Þ., & Duchêne, D. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.044 · Cited by 1,766 · see citing works
Pharmaceutical Applications of Cyclodextrins. 2. In Vivo Drug Delivery
Rajewski, R. A., & Stella, V. J. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js960075u · Cited by 823 · see citing works
Cyclodextrins and Their Complexes
Morillo González, E. (2006) · Wiley eBooks · doi:10.1002/3527608982 · Cited by 729 · see citing works
Cyclodextrins and their industrial uses
Connors, K. A. (1988) · Journal of Controlled Release · doi:10.1016/0168-3659(88)90086-7 · Cited by 535 · see citing works
Biotechnological applications of cyclodextrins
Singh, M., Sharma, R., & Banerjee, U. C. (2002) · Biotechnology Advances · doi:10.1016/s0734-9750(02)00020-4 · Cited by 500 · see citing works
Cyclodextrins in topical drug formulations: theory and practice
Loftsson, Þ., & Másson, M. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00761-x · Cited by 474 · see citing works
Thermal analysis of cyclodextrins and their inclusion compounds
Giordano, F., Novak, C., & Moyano, J. R. (2001) · Thermochimica Acta · doi:10.1016/s0040-6031(01)00665-7 · Cited by 319 · see citing works
Role of Cyclodextrins in Improving Oral Drug Delivery
Loftsson, Þ., Brewster, M. E., & M??sson, M. (2004) · American Journal of Drug Delivery · doi:10.2165/00137696-200402040-00006 · Cited by 288 · see citing works
Augustät, S. (1981) · Food / Nahrung · doi:10.1002/food.19810250714 · Cited by 208 · see citing works
Thermal degradation of cyclodextrins
Trotta, F., Zanetti, M., & Camino, G. (2000) · Polymer Degradation and Stability · doi:10.1016/s0141-3910(00)00084-7 · Cited by 185 · see citing works
Cyclodextrin glucanotransferase: from gene to applications
Qi, Q., & Zimmermann, W. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1781-5 · Cited by 172 · see citing works
Photoisomerization of octyl methoxycinnamate
Pattanaargson, S., Munhapol, T., Hirunsupachot, P., & Luangthongaram, P. (2003) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/s1010-6030(03)00282-x · Cited by 116 · see citing works
Cyclodextrins as Food Additives and in Food Processing
Cravotto, G., Binello, A. E., Baranelli, E., Carraro, P., & Trotta, F. (2006) · Current Nutrition & Food Science · doi:10.2174/157340106778699485 · Cited by 97 · see citing works
Kohata, S., Jyodoi, K., & Ohyoshi, A. (1993) · Thermochimica Acta · doi:10.1016/0040-6031(93)85107-k · Cited by 87 · see citing works
Zhong, Q., He, L., Beesley, T. E., Trahanovsky, W. S., Sun, P., Wang, C., & Armstrong, D. W. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.02.065 · Cited by 87 · see citing works
Stability of octyl methoxycinnamate and identification of its photo‐degradation product
Pattanaargson, S., & Limphong, P. (2001) · International Journal of Cosmetic Science · doi:10.1046/j.1467-2494.2001.00071.x · Cited by 84 · see citing works
Scalia, S., Casolari, A., Iaconinoto, M. A., & Simeoni, S. (2002) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(02)00433-8 · Cited by 63 · see citing works
Indomethacin and cyclodextrin complexes
Lin, S.-Z., Wouessidjewe, D., Poelman, M.-C., & Duchêne, D. (1991) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(91)90363-s · Cited by 61 · see citing works
Kirschner, D. L., Jaramillo, M., & Green, T. K. (2006) · Analytical Chemistry · doi:10.1021/ac061725+ · Cited by 56 · see citing works
Felton, L. A., Wiley, C. J., & Godwin, D. A. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120014578 · Cited by 52 · see citing works
Bani‐Yaseen, A. D., Al‐Rawashdeh, N. A. F., & Al-Momani, I. F. (2008) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-008-9493-6 · Cited by 35 · see citing works
Self-citationGhorab, M. K., & Adeyeye, M. C. (2001) · Pharmaceutical Development and Technology · doi:10.1081/pdt-100002612 · Cited by 33 · see citing works
Skin permeation of two different benzophenone derivatives from various vehicles
Kurul, E., & Hekimoğlu, S. (2001) · International Journal of Cosmetic Science · doi:10.1046/j.1467-2494.2001.00089.x · Cited by 31 · see citing works
Transdermal Permeation Modulation by Cyclodextrins: A Mechanistic Study
Williams, A. C., Shatri, S. R. S., & Barry, B. W. (1998) · Pharmaceutical Development and Technology · doi:10.3109/10837459809009856 · Cited by 30 · see citing works
Yang, G., Chen, D. M., Yang, Y., Tang, B., Gao, J.-Z., Aboul-Enein, H. Y., & Koppenhoefer, B. (2005) · Chromatographia · doi:10.1365/s10337-005-0632-6 · Cited by 29 · see citing works
Theory and Use of the Pseudophase Model in Gas−Liquid Chromatographic Enantiomeric Separations
Pino, V., Lantz, A. W., Anderson, J. L., Berthod, A., & Armstrong, D. W. (2005) · Analytical Chemistry · doi:10.1021/ac051289b · Cited by 28 · see citing works
Henley, W. H., Wilburn, R. T., Crouch, A. M., & Jorgenson, J. W. (2005) · Analytical Chemistry · doi:10.1021/ac050742g · Cited by 24 · see citing works
Chiral Separation by Capillary Electrochromatography Using Cyclodextrin Phases
Wistuba, D., Kang, J., & Schurig, V. (2004) · Humana Press eBooks · doi:10.1385/1-59259-648-7:401 · Cited by 6 · see citing works
Flagged first, then by citations
2 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
UV Filters: Challenges and Prospects
Jesus, A., Sousa, E., Cruz, M., Cidade, H., Lobo, J., & Almeida, I. (2022) · Pharmaceuticals · doi:10.3390/ph15030263 · Cited by 132 · see citing works
Loh, G. O. K., Tan, Y. T. F., & Peh, K.-K. (2016) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2016.02.009 · Cited by 105 · see citing works
Gao, S., Zong, L., Zhang, Y., Zhang, Y., Guo, X., Guo, G., Zhao, L., Ye, F., & Fu, Y. (2023) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2023.137499 · Cited by 74 · see citing works
New Hybrid Organic/Inorganic Polysilsesquioxane–Silica Particles as Sunscreens
Tolbert, S. H., McFadden, P. D., & Loy, D. A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b10472 · Cited by 68 · see citing works
Savic, I. M., Nikolić, V. D., Savić, I., Nikolic, L. B., Radovanović, B. C., & Mladenovic, J. D. (2015) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-015-0500-4 · Cited by 52 · see citing works
Savic, I. M., Savić, I., Nikolić, V. D., Nikolic, L. B., Radovanović, B. C., & Milenkovic-Andjelkovic, A. (2016) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-016-0638-8 · Cited by 50 · see citing works
Investigation of inclusion complex of honokiol with sulfobutyl ether-β-cyclodextrin
Xu, C., Tang, Y., Hu, W., Tian, R., Jia, Y., Deng, P., & Zhang, L. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.06.059 · Cited by 46 · see citing works
Nikolić, I., Savic, I. M., Popsavin, M. M., Rakić, S., Mihajilov‐Krstev, T., Ristić, I., Erić, S., & Savić, I. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13003 · Cited by 42 · see citing works
Liu, B., Duan, J., Zhang, Y., Wang, R., Zhao, L., Gao, S., Ye, F., & Fu, Y. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.137195 · Cited by 41 · see citing works
Cyclodextrin-based delivery systems for dietary pharmaceuticals
Arora, D., Saneja, A., & Jaglan, S. (2019) · Environmental Chemistry Letters · doi:10.1007/s10311-019-00878-w · Cited by 39 · see citing works
Savić, I., Savic, I. M., Nikolić, V. D., Nikolic, L. B., Popsavin, M. M., & Kapor, Á. (2016) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-016-0635-y · Cited by 38 · see citing works
Zhang, Z., Niu, J., Wang, J., Zheng, Q., Miao, W., Lin, Q., Li, X., Jin, Z., Qiu, C., Sang, S., et al. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114952 · Cited by 37 · see citing works
Host-guest interaction of cytidine in β-cyclodextrin microcavity: Characterization and docking study
Prabu, S., Sivakumar, K., Nayaki, S. K., & Rajamohan, R. (2016) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2016.04.017 · Cited by 33 · see citing works
Inclusion complexes of sulfanilamide with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin
Tačić, A., Savic, I. M., Nikolić, V. D., Savić, I., Ilić-Stojanović, S. S., Ilić, D., Petrovic, S. D., Popsavin, M. M., & Kapor, Á. (2014) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-014-0410-x · Cited by 30 · see citing works
Berbicz, F., Nogueira, A. C., Neto, A. M., Natali, M. R. M., Baesso, M. L., & Matioli, G. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.03.026 · Cited by 30 · see citing works
Niosomes Encapsulating Ibuprofen–Cyclodextrin Complexes: Preparation and Characterization
Marianecci, C., Rinaldi, F., Esposito, S. A., Marzio, L. D., & Carafa, M. (2013) · Current Drug Targets · doi:10.2174/1389450111314090015 · Cited by 28 · see citing works
Al‐Rawashdeh, N. A. F., Al-Sadeh, K. S., & Al-Bitar, M. B. (2013) · Journal of Spectroscopy · doi:10.1155/2013/841409 · Cited by 23 · see citing works
Self-citationThe real value of novel particulate carriers for sunscreen formulation
Blasi, P., Schoubben, A., Giovagnoli, S., Rossi, C. R., & Ricci, M. (2011) · Expert Review of Dermatology · doi:10.1586/edm.11.57 · Cited by 20 · see citing works
Inclusion complexes of trihexyphenidyl with natural and modified cyclodextrins
Maeda, H., Tanaka, R., & Nakayama, H. (2015) · SpringerPlus · doi:10.1186/s40064-015-0986-7 · Cited by 11 · see citing works
Al-Abboodi, A. S., Abdullah, R., Abdul, A. B., Taufiq‐Yap, Y. H., AL-QUBAISI, M. S., & Eid, E. E. M. (2017) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-016-0688-y · Cited by 11 · see citing works
Encapsulation of Cinnamic Acid by Cucurbit[7]uril for Enhancing Photoisomerization
Saleh, N. A. I., Bufaroosha, M. S., Moussa, Z., Bojesomo, R. S., Al-Amodi, H., & Al-Ahdal, A. (2020) · Molecules · doi:10.3390/molecules25163702 · Cited by 9 · see citing works
Abdel‐Maksoud, G., Nasr, H. E., Samaha, S. H., & Kassem, M. S.-E. (2024) · Heritage Science · doi:10.1186/s40494-024-01294-2 · Cited by 7 · see citing works
Cyclodextrin-Based Carriers for Delivery of Dietary Phytochemicals
Arora, D., Saneja, A., & Jaglan, S. (2018) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-319-76162-6_1 · Cited by 5 · see citing works
Comparison of lipophilic and size-exclusion membranes: creating sink conditions with cyclodextrin
Tőzsér, P., Kádár, S., Szabó, E., Pataki, H., Sóti, P. L., Laczay, P., Balogh, G. T., Sinkó, B., & Borbás, E. (2025) · ADMET & DMPK · doi:10.5599/admet.2859 · Cited by 1 · see citing works
Tőzsér, P., Kádár, S., Szabó, E., Dobó, M., Tóth, G., Balogh, G. T., Sóti, P. L., Sinkó, B., & Borbás, E. (2025) · ADMET & DMPK · doi:10.5599/admet.2753 · Cited by 1 · see citing works
Photochemical behavior of UV filter combinations
Fernández-Álvarez, M. D. M., Llompart, M., Sánchez-Prado, L., Garcı́a-Jares, C., & Lores, M. (2013) · Cited by 1 · see citing works
de Souza, J. B. P., Barros, A. M. H. D. P., Silva, C. C., de Almeida, A. R., Ferreira, L. D. S., Silva, A. L. E., Tavares, J. F., dos Santos, J. R., Rocha, H. A. O., Cordeiro, L. V., et al. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108763
- Authors
- Al-Rawashdeh, N. A. F., Al-Sadeh, K. S., & Al-Bitar, M.-B.
- Affiliations
- Jordan University of Science and Technology (JO)
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 2010-01-05
- Volume
- 36
- Issue
- 6
- Pages
- 688-697
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2122694212
- Cited by
- 27
- References
- 33
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 3
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deanship of Research, Jordan University of Science and Technology
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Keywords
- hydroxypropyl-β-cyclodextrin, microencapsulation, UV filters, inclusion complexes, benzophenone-3, octocrylene, ethylhexyl methoxycinnamate, photostability, photodegradation, isomerization, photostabilizers, sunscreen lotion
- MeSH terms
- 2-Hydroxypropyl-beta-cyclodextrin, Administration, Cutaneous, Chemistry, Pharmaceutical, Drug Compounding, Sunscreening Agents, beta-Cyclodextrins, Chemical Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review