Cited by 27Drug Solubulity and Delivery SystemsSkin Protection and AgingSurfactants and Colloidal Systems

Physicochemical study on microencapsulation of hydroxypropyl-β-cyclodextrin in dermal preparations

Al-Rawashdeh, Nathir A.F., Al-Sadeh, Khaled S., Al-Bitar, Mohammad-Bassam·2010·Drug Development and Industrial Pharmacy

Abstract

Objective To investigate the effect of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) concentration on the physicochemical properties of the sunscreen agents, namely oxybenzone (Oxy), octocrylene (Oct), and ethylhexyl-methoxy-cinnamate (Cin), in aqueous solution and cream formulations. Methods The inclusion complexes of sunscreen agents with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in aqueous solution and solid phase were studied by UV-vis spectrophotmetery, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and 13C-NMR techniques. The photodegradation reaction of the sunscreen agents' molecules in lotion was explored using UV-vis spectrophotometry and high-performance liquid chromatography (HPLC). Results The formation of the inclusion complexes was confirmed experimentally using DSC, SEM, and 13C-NMR. The results of spectrophotometric and HPLC studies have shown that the inclusion complexation with HP-beta-CD has the potential to enhance the photostability of the selected sunscreen agents in lotion. HPLC results indicated that HP-beta-CD has approximately increases the photostability of Oct by six- to eightfold. Moreover, the presence of HP-beta-CD in lotion controlled the isomerization process of Cin to a certain degree, which was found to be a function of the amount of HP-beta-CD added. Conclusions It has been demonstrated that the photostability of the tested sunscreen agents has been enhanced upon forming inclusion complexes with HP-beta-CD i…

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Crossref · 10.3109/03639040903449738

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  • Micro-encapsulation of oxybenzone, EHMC, and octocrylene in hydroxypropyl-β-cyclodextrins acts as photostabilisers.

    “Al-Rawashdeh et al. (2010) reported the micro-encapsulation of commercial UV filters (oxybenzone (10), EHMC (21), and octocrylene (30)) in hydroxypropyl-β-cyclodextrins system that successfully acted as photostabilisers [44].”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [44]

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Authors
Al-Rawashdeh, N. A. F., Al-Sadeh, K. S., & Al-Bitar, M.-B.
Affiliations
Jordan University of Science and Technology (JO)
Venue
Drug Development and Industrial Pharmacy
Published
2010-01-05
Volume
36
Issue
6
Pages
688-697
ISSN
  • 0363-9045 (ISSN-L)
  • 1520-5762
OpenAlex
W2122694212
Cited by
27
References
33
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 3
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Development and Industrial Pharmacy (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deanship of Research, Jordan University of Science and Technology
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
hydroxypropyl-β-cyclodextrin, microencapsulation, UV filters, inclusion complexes, benzophenone-3, octocrylene, ethylhexyl methoxycinnamate, photostability, photodegradation, isomerization, photostabilizers, sunscreen lotion
MeSH terms
2-Hydroxypropyl-beta-cyclodextrin, Administration, Cutaneous, Chemistry, Pharmaceutical, Drug Compounding, Sunscreening Agents, beta-Cyclodextrins, Chemical Phenomena

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