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Cited by 298

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites

Yue, Wei, Ming, Qian-liang, Lin, Bing, Rahman, Khalid, Zheng, Cheng-Jian, Han, Ting, Qin, Lu-ping·2016·Critical Reviews in Biotechnology

Abstract

The development of plant tissue (including organ and cell) cultures for the production of secondary metabolites has been underway for more than three decades. Plant cell cultures with the production of high-value secondary metabolites are promising potential alternative sources for the production of pharmaceutical agents of industrial importance. Medicinal plant cell suspension cultures (MPCSC), which are characterized with the feature of fermentation with plant cell totipotency, could be a promising alternative "chemical factory". However, low productivity becomes an inevitable obstacle limiting further commercialization of MPCSC and the application to large-scale production is still limited to a few processes. This review generalizes and analyzes the recent progress of this bioproduction platform for the provision of medicinal chemicals and outlines a range of trials taken or underway to increase product yields from MPCSC. The scale-up of MPCSC, which could lead to an unlimited supply of pharmaceuticals, including strategies to overcome and solution of the associated challenges, is discussed.

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Metadata

Authors
Yue, W., Ming, Q.-L., Lin, B., Rahman, K., Zheng, C.-J., Han, T., & Qin, L.-P.
Venue
Critical Reviews in Biotechnology
Published
2014-06-25
Volume
36
Issue
2
Pages
215-232
ISSN
  • 0738-8551 (ISSN-L)
  • 1549-7801
OpenAlex
W1977294506
Cited by
298
References
91
FWCI
3.04
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites. https://app.cochat.ai/papers/10.3109/07388551.2014.923986
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Yue, W., Ming, Q.-L., Lin, B., Rahman, K., Zheng, C.-J., Han, T., & Qin, L.-P. (2016). Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites. Critical Reviews in Biotechnology. https://doi.org/10.3109/07388551.2014.923986

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