The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites
Abstract
The development of plant tissue (including organ and cell) cultures for the production of secondary metabolites has been underway for more than three decades. Plant cell cultures with the production of high-value secondary metabolites are promising potential alternative sources for the production of pharmaceutical agents of industrial importance. Medicinal plant cell suspension cultures (MPCSC), which are characterized with the feature of fermentation with plant cell totipotency, could be a promising alternative "chemical factory". However, low productivity becomes an inevitable obstacle limiting further commercialization of MPCSC and the application to large-scale production is still limited to a few processes. This review generalizes and analyzes the recent progress of this bioproduction platform for the provision of medicinal chemicals and outlines a range of trials taken or underway to increase product yields from MPCSC. The scale-up of MPCSC, which could lead to an unlimited supply of pharmaceuticals, including strategies to overcome and solution of the associated challenges, is discussed.
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Dini, I., & Laneri, S. (2021) · Molecules · doi:10.3390/molecules26133921 · Cited by 217
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Georgiev, V., Slavov, A., Vasileva, I., & Pavlov, A. (2018) · Engineering in Life Sciences · doi:10.1002/elsc.201800066 · Cited by 139
Recent Applications of Plant Cell Culture Technology in Cosmetics and Foods
Krasteva, G., Georgiev, V., & Pavlov, A. (2021) · Engineering in Life Sciences · doi:10.1002/elsc.202000078 · Cited by 116
Ahmad, A., Tahir ul Qamar, M., Shoukat, A., Aslam, M. M., Tariq, M., Hakiman, M., & Joyia, F. A. (2021) · PeerJ · doi:10.7717/peerj.11464 · Cited by 29
Metadata
- Authors
- Yue, W., Ming, Q.-L., Lin, B., Rahman, K., Zheng, C.-J., Han, T., & Qin, L.-P.
- Venue
- Critical Reviews in Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2014-06-25
- Volume
- 36
- Issue
- 2
- Pages
- 215-232
- ISSN
- 0738-8551 (ISSN-L)
- 1549-7801
- OpenAlex
- W1977294506
- Cited by
- 298
- References
- 91
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yue, W., Ming, Q.-L., Lin, B., Rahman, K., Zheng, C.-J., Han, T., & Qin, L.-P. (2016). Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites. Critical Reviews in Biotechnology. https://doi.org/10.3109/07388551.2014.923986
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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