Plant tissue culture as a perpetual source for production of industrially important bioactive compounds
Open accessAbstract
Plants have been used throughout the world for its medicinal powers since ancient time. The pharmacological properties of plants are based on their phytochemical components especially the secondary metabolites which are outstanding sources of value added bioactive compounds. Secondary metabolites have complex chemical composition and are produced in response to various forms of stress to perform different physiological tasks in plants. They are used in pharmaceutical industries, cosmetics, dietary supplements, fragrances, flavors, dyes, etc. Extended use of these metabolites in various industrial sectors has initiated a need to focus research on increasing the production by employing plant tissue culture (PTC) techniques and optimizing their large scale production using bioreactors. PTC techniques being independent of climatic and geographical conditions will provide an incessant, sustainable, economical and viable production of secondary metabolites. This review article intends to assess the advantages of using plant tissue culture, distribution of important secondary metabolites in plant families, strategies involved for optimal metabolite production and the industrial importance of selected secondary metabolites.
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Plant tissue culture is a powerful tool for reproducing identical plants of a genotype from a single plant part without dependence on geographical and climatic factors.
“Nowadays, plant tissue culture is a powerful tool for reproducing identical plants of a genotype from a single plant part without dependence on geographical and climatic factors [4].”
From Somaclonal Variation and Clonal Fidelity in Commercial Micropropagation: Challenges and Perspectives (2025) · cites this paper as [4]
Plant tissue culture is an alternative method of conventional vegetative propagation.
“Thus, plant tissue culture is an alternative method of conventional vegetative propagation [4,5].”
From Somaclonal Variation and Clonal Fidelity in Commercial Micropropagation: Challenges and Perspectives (2025) · cites this paper as [4]
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MYB transcription factors in Arabidopsis
Dubos, C., Stracke, R., Erich Grotewold, A., Weißhaar, B., Martin, C. R., & Lepiniec, L. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.06.005 · Cited by 4,885 · see citing works
Ekor, M. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00177 · Cited by 3,919 · see citing works
Discovery and resupply of pharmacologically active plant-derived natural products: A review
Atanasov, A. G., Waltenberger, B., Pferschy‐Wenzig, E., Linder, T., Wawrosch, C., Uhrín, P., Temml, V., Wang, L., Schwaiger, S., Heiß, E. H., et al. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.08.001 · Cited by 3,009 · see citing works
Influence of abiotic stress signals on secondary metabolites in plants
Ramakrishna, A., & Ravishankar, G. A. (2011) · Plant Signaling & Behavior · doi:10.4161/psb.6.11.17613 · Cited by 2,526 · see citing works
The Traditional Medicine and Modern Medicine from Natural Products
Yuan, H.-D., Ma, Q., Li, Y., & Piao, G. (2016) · Molecules · doi:10.3390/molecules21050559 · Cited by 2,451 · see citing works
Elicitor signal transduction leading to production of plant secondary metabolites
Zhao, J. H., Davis, L. C., & Verpoorte, R. (2005) · Biotechnology Advances · doi:10.1016/j.biotechadv.2005.01.003 · Cited by 1,962 · see citing works
Transcriptional control of flavonoid biosynthesis by MYB–bHLH–WDR complexes
Xu, W., Dubos, C., & Lepiniec, L. (2015) · Trends in Plant Science · doi:10.1016/j.tplants.2014.12.001 · Cited by 1,933 · see citing works
The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants
Maeda, H. A., & Dudareva, N. (2012) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105439 · Cited by 1,568 · see citing works
Herrmann, K. M., & Weaver, L. M. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.473 · Cited by 1,343 · see citing works
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery
Thomford, N. E., Senthebane, D. A., Rowe, A., Munro, D., Seele, P. P., Maroyi, A., & Dzobo, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061578 · Cited by 1,268 · see citing works
Refined structure of αβ-tubulin at 3.5 Å resolution 1 1Edited by I. A. Wilson
Löwe, J., Li, H., Downing, K. H., & Nogales, E. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5077 · Cited by 1,139 · see citing works
Nanotechnology: A New Opportunity in Plant Sciences
Wang, P., Lombi, E., Zhao, F. J., & Kopittke, P. M. (2016) · Trends in Plant Science · doi:10.1016/j.tplants.2016.04.005 · Cited by 1,087 · see citing works
Modes of Action of Herbal Medicines and Plant Secondary Metabolites
Wink, M. (2015) · Medicines · doi:10.3390/medicines2030251 · Cited by 953 · see citing works
ORCA3, a Jasmonate-Responsive Transcriptional Regulator of Plant Primary and Secondary Metabolism
van der Fits, L., & Memelink, J. (2000) · Science · doi:10.1126/science.289.5477.295 · Cited by 933 · see citing works
Anand, U., Jacobo-Herrera, N. J., Altemimi, A. B., & Lakhssassi, N. (2019) · Metabolites · doi:10.3390/metabo9110258 · Cited by 871 · see citing works
Albert, N. W., Davies, K. M., Lewis, D. H., Zhang, H., Montefiori, M., Brendolise, C., Boase, M. R., Ngo, H. M., Jameson, P. E., & Schwinn, K. E. (2014) · The Plant Cell · doi:10.1105/tpc.113.122069 · Cited by 807 · see citing works
The Catharanthus Alkaloids:Pharmacognosy and Biotechnology
van der Heijden, R., Jacobs, D. I., Snoeijer, W., Hallard, D., & Verpoorte, R. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043455846 · Cited by 729 · see citing works
Murthy, H. N., Lee, E., & Paek, K. (2014) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-014-0467-7 · Cited by 685 · see citing works
Current approaches toward production of secondary plant metabolites
Hussain, M. S., Fareed, S., Ansari, S., Rahman, M. A., Ahmad, I. Z., & Saeed, M. (2012) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.92725 · Cited by 637 · see citing works
METABOLIC CHANNELING IN PLANTS
Winkel, A. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141714 · Cited by 621 · see citing works
Ramírez‐Estrada, K., Vidal‐Limon, H., Hidalgo, D., Moyano, E., Golenioswki, M., Cusido, R. M., & Palazón, J. (2016) · Molecules · doi:10.3390/molecules21020182 · Cited by 612 · see citing works
Biotechnology for the production of plant secondary metabolites
Verpoorte, R., Contin, A., & Memelink, J. (2002) · Phytochemistry Reviews · doi:10.1023/a:1015871916833 · Cited by 606 · see citing works
Calixto, J. Β., Santos, A. R. S., Filho, V. C., & Yunes, R. A. (1998) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199807)18:4 · Cited by 547 · see citing works
Metabolon formation and metabolic channeling in the biosynthesis of plant natural products
Jørgensen, K., Rasmussen, A. V., Morant, M., Nielsen, A. H., Bjarnholt, N., Zagrobelny, M., Bak, S., & Møller, B. L. (2005) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2005.03.014 · Cited by 538 · see citing works
Nanoparticles and higher plants
Monica, R. C., & Cremonini, R. (2009) · Caryologia · doi:10.1080/00087114.2004.10589681 · Cited by 531 · see citing works
New concepts in nutraceuticals as alternative for pharmaceuticals.
Nasri, H., Baradaran, A., Shirzad, H., & Rafieian‐Kopaei, M. (2014) · Europe PMC (PubMed Central) · Cited by 525 · see citing works
Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants
Hussein, R. A., & El‐Anssary, A. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.76139 · Cited by 494 · see citing works
Marinova, K., Pourcel, L., Weder, B., Schwarz, M., Barron, D., Routaboul, J., Debeaujon, I., & Klein, M. (2007) · The Plant Cell · doi:10.1105/tpc.106.046029 · Cited by 485 · see citing works
Yu, Z.-X., Li, J., Yang, C., Hu, W., Wang, L.-J., & Chen, X. (2011) · Molecular Plant · doi:10.1093/mp/ssr087 · Cited by 474 · see citing works
Xu, Y., Wang, J., Wang, S., Wang, J., & Chen, X. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.038612 · Cited by 461 · see citing works
Biotechnology Applications of Plant Callus Cultures
Efferth, T. (2018) · Engineering · doi:10.1016/j.eng.2018.11.006 · Cited by 444 · see citing works
Mahmoud, S. S., & Croteau, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141237298 · Cited by 435 · see citing works
Karuppusamy, S. (2009) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000026 · Cited by 415 · see citing works
Production of Plant Secondary Metabolites: Examples, Tips and Suggestions for Biotechnologists
Guerriero, G., Berni, R., Muñoz-Sánchez, J. A., Apone, F., Abdel-Salam, E. M., Qahtan, A. A., Alatar, A. A., Cantini, C., Cai, G., Hausman, J.-F., et al. (2018) · Genes · doi:10.3390/genes9060309 · Cited by 406 · see citing works
Transcriptional Regulation of Plant Secondary MetabolismF
Yang, C., Fang, X., Wu, X., Mao, Y., Wang, L., & Chen, X. (2012) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2012.01161.x · Cited by 397 · see citing works
Interactions among enzymes of the Arabidopsis flavonoid biosynthetic pathway
Burbulis, I. E., & Winkel, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12929 · Cited by 387 · see citing works
Elicitation: A Tool for Enriching the Bioactive Composition of Foods
Baenas, N., García‐Viguera, C., & Moreno, D. A. (2014) · Molecules · doi:10.3390/molecules190913541 · Cited by 386 · see citing works
Biologically Active and Other Chemical Constituents of the Herb ofHypericum perforatumL.
Nahrstedt, A., & Butterweck, V. (1997) · Pharmacopsychiatry · doi:10.1055/s-2007-979533 · Cited by 379 · see citing works
Greeson, J. M., Sanford, B., & Monti, D. (2001) · Psychopharmacology · doi:10.1007/s002130000625 · Cited by 379 · see citing works
Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review
Malik, S., Cusido, R. M., Mirjalili, M. H., Moyano, E., Palazón, J., & Bonfill, M. (2010) · Process Biochemistry · doi:10.1016/j.procbio.2010.09.004 · Cited by 374 · see citing works
Nanoparticles based on essential metals and their phytotoxicity
Ruttkay-Nedecký, B., Kryštofová, O., Nejdl, L., & Adam, V. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-017-0268-3 · Cited by 358 · see citing works
Rational Phytotherapy: A Physicians' Guide to Herbal Medicine
Schulz, V., Hänsel, R., Tyler, V. E., & Telger, T. C. (1997) · Cited by 356 · see citing works
Makkar, H. P. S., Siddhuraju, P., & Becker, K. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-425-4_1 · Cited by 351 · see citing works
St‐Pierre, B., Vázquez‐Flota, F., & Luca, V. D. (1999) · The Plant Cell · doi:10.1105/tpc.11.5.887 · Cited by 351 · see citing works
Plant cell culture strategies for the production of natural products
Ochoa-Villarreal, M., Howat, S., Hong, S., Jang, M. O., Jin, Y.-W., Lee, E.-K., & Loake, G. J. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.3.264 · Cited by 349 · see citing works
Isah, T., Umar, S., Mujib, A., Sharma, M. P., Rajasekharan, P. E., Zafar, N., & Frukh, A. (2017) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1332-2 · Cited by 341 · see citing works
Ma, D., Pu, G., Lei, C., Ma, L., Wang, H., Guo, Y., Chen, J., Du, Z., Wang, H., Li, G., et al. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp149 · Cited by 333 · see citing works
Metabolic Engineering of Plant Secondary Metabolism
(2000) · Springer eBooks · doi:10.1007/978-94-015-9423-3 · Cited by 316 · see citing works
Yue, W., Ming, Q., Lin, B., Rahman, K., Zheng, C., Han, T., & Qin, L. (2014) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2014.923986 · Cited by 299 · see citing works
Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology
Kolewe, M. E., Gaurav, V., & Roberts, S. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp7001494 · Cited by 294 · see citing works
Sulaiman, G. M., Mohammed, W. H., Marzoog, T. R., Al‐Amiery, A. A., Kadhum, A. A. H., & Mohamad, A. B. (2013) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(13)60024-6 · Cited by 274 · see citing works
Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures
Zhang, L., Ding, R., Chai, Y., Bonfill, M., Moyano, E., Oksman‐Caldentey, K., Tie-feng, X., ., Y. P., Wang, Z., Zhang, H., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401391101 · Cited by 274 · see citing works
Jasim, B., Thomas, R., Mathew, J., & Radhakrishnan, E. K. (2016) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2016.09.012 · Cited by 272 · see citing works
Eukaryotic transcription factors
Latchman, D. S. (1990) · Biochemical Journal · doi:10.1042/bj2700281 · Cited by 271 · see citing works
Transcription factors as tools for metabolic engineering in plants
Broun, P. (2004) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2004.01.013 · Cited by 268 · see citing works
Medicinal plants: chemistry and properties
(2006) · Choice Reviews Online · doi:10.5860/choice.43-6524 · Cited by 255 · see citing works
Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures
Xu, J., Ge, X., & Dolan, M. C. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.01.002 · Cited by 245 · see citing works
Cell and tissue cultures of Catharanthus roseus: A literature survey
Moreno, P. R. H., van der Heijden, R., & Verpoorte, R. (1995) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/bf00037677 · Cited by 244 · see citing works
Catharanthus terpenoid indole alkaloids: biosynthesis and regulation
El-Sayed, M., & Verpoorte, R. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-006-9047-8 · Cited by 240 · see citing works
Garcı́a, S. C., Bernales, I., & Cristóbal, S. (2015) · BMC Genomics · doi:10.1186/s12864-015-1530-4 · Cited by 236 · see citing works
Giri, C. C., & Zaheer, M. (2016) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-016-0985-6 · Cited by 229 · see citing works
Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools
Siddiqui, M. S., Thodey, K., Trenchard, I. J., & Smolke, C. D. (2011) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00774.x · Cited by 226 · see citing works
An Introductory Chapter: Secondary Metabolites
Thirumurugan, D., Alagappan, C., Raja, S. S. S., & Vijayakumar, R. (2018) · InTech eBooks · doi:10.5772/intechopen.79766 · Cited by 215 · see citing works
Canel, C., Lopes-Cardoso, M. I., Whitmer, S., van der Fits, L., Pasquali, G., van der Heijden, R., Hoge, J. H. C., & Verpoorte, R. (1998) · Planta · doi:10.1007/s004250050338 · Cited by 207 · see citing works
Yu, K.-W., Murthy, H. N., Hahn, E.-J., & Paek, K. (2004) · Biochemical Engineering Journal · doi:10.1016/j.bej.2004.07.001 · Cited by 206 · see citing works
Govindachari, T. R., & Viswanathan, N. (1972) · Phytochemistry · doi:10.1016/s0031-9422(00)89852-0 · Cited by 179 · see citing works
Zhou, L., & Wu, J. (2006) · Natural Product Reports · doi:10.1039/b610767b · Cited by 176 · see citing works
Zhang, B., Zheng, L. P., Li, W. Y., & Wang, J. (2013) · Current Nanoscience · doi:10.2174/1573413711309030012 · Cited by 175 · see citing works
Walker, T. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00074-2 · Cited by 173 · see citing works
Muñoz‐Bertomeu, J., Arrillaga, I., Ros, R., & Segura, J. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.086355 · Cited by 171 · see citing works
Evaluating costs for the in vitro propagation and preservation of endangered plants
Pence, V. C. (2010) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-010-9323-6 · Cited by 170 · see citing works
Advances and challenges on the in vitro production of secondary metabolites from medicinal plants
Cardoso, J. C., de Oliveira, M. E. B. S., & Cardoso, F. D. C. I. (2019) · Horticultura Brasileira · doi:10.1590/s0102-053620190201 · Cited by 164 · see citing works
Changes of primary and secondary metabolites in barley plants exposed to CdO nanoparticles
Večeřová, K., Večeřa, Z., Dočekal, B., Oravec, M., Pompeiano, A., Třı́ska, J., & Urban, O. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.05.013 · Cited by 151 · see citing works
Tilting Plant Metabolism for Improved Metabolite Biosynthesis and Enhanced Human Benefit
Ncube, B., & Staden, J. V. (2015) · Molecules · doi:10.3390/molecules200712698 · Cited by 148 · see citing works
Shakya, P., Marslin, G., Siram, K., Beerhues, L., & Franklin, G. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12743 · Cited by 148 · see citing works
Onrubia, M., Moyano, E., Bonfill, M., Cusido, R. M., Goossens, A., & Palazón, J. (2012) · Journal of Plant Physiology · doi:10.1016/j.jplph.2012.09.004 · Cited by 142 · see citing works
Rational Phytotherapy (A Physicians’ Guide to Herbal Medicine),
Adolfo Andrade-cetto, A. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00259-8 · Cited by 137 · see citing works
Gorelick, J., & Bernstein, N. (2014) · Advances in agronomy · doi:10.1016/b978-0-12-800138-7.00005-x · Cited by 134 · see citing works
Pan, Q., Wang, Q., Yuan, F., Xing, S., Zhao, J., Choi, Y. H., Verpoorte, R., Tian, Y., Wang, G., & Tang, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043038 · Cited by 133 · see citing works
Influence of Fungal Elicitors on Production of Ajmalicine by Cell Cultures of Catharanthus roseus
Namdeo, A. G., Patil, S., & Fulzele, D. P. (2002) · Biotechnology Progress · doi:10.1021/bp0101280 · Cited by 133 · see citing works
Towards molecular farming in the future: using plant‐cell‐suspension cultures as bioreactors
Fischer, R., Emans, N., Schuster, F., Hellwig, S., & Drossard, J. (1999) · Biotechnology and Applied Biochemistry · doi:10.1111/j.1470-8744.1999.tb00899.x · Cited by 130 · see citing works
The genetic manipulation of medicinal and aromatic plants
Gómez‐Galera, S., Pelacho, A. M., Gené, A., Capell, T., & Christou, P. (2007) · Plant Cell Reports · doi:10.1007/s00299-007-0384-x · Cited by 127 · see citing works
DellaPenna, D. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.1.160 · Cited by 127 · see citing works
New insight into the structures and formation of anthocyanic vacuolar inclusions in flower petals.
Zhang, H., Wang, L., Deroles, S. C., Bennett, R., & Davies, K. M. (2006) · BMC Plant Biology · doi:10.1186/1471-2229-6-29 · Cited by 125 · see citing works
Characterization of Vacuolar Transport of the Endogenous Alkaloid Berberine in Coptis japonica
Otani, M., Shitan, N., Sakai, K., Martinoia, E., Sato, F., & Yazaki, K. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.064352 · Cited by 125 · see citing works
Plant resources of tropical Africa 11 (1). Medicinal plants 1.
Schmelzer, G. H., Gurib‐Fakim, A., Arroo, R., Bosch, C., de Ruijter, A., Simmonds, M. S. J., Lemmens, R., & Oyen, L. P. A. (2008) · DMU Open Research Archive (De Montfort University) · Cited by 119 · see citing works
Mohammed, A. E. (2015) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(15)30373-7 · Cited by 108 · see citing works
Production of Plant Secondary Metabolites by Using Biotechnological Tools
Gonçalves, S., & Romano, A. (2018) · InTech eBooks · doi:10.5772/intechopen.76414 · Cited by 107 · see citing works
Manipulating Gene Expression for the Metabolic Engineering of Plants
Lessard, P. A., Kulaveerasingam, H., York, G. M., Strong, A., & Sinskey, A. J. (2002) · Metabolic Engineering · doi:10.1006/mben.2001.0210 · Cited by 105 · see citing works
Jadaun, J. S., Sangwan, N. S., Narnoliya, L. K., Singh, N., Bansal, S., Mishra, B., & Sangwan, R. S. (2016) · Physiologia Plantarum · doi:10.1111/ppl.12507 · Cited by 100 · see citing works
Phenolic compounds in Catharanthus roseus
Mustafa, N. R., & Verpoorte, R. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-006-9039-8 · Cited by 99 · see citing works
Organic Chemistry: With Biological Applications
McMurry, J. E. (2007) · Cited by 96 · see citing works
Synthetic biological approaches to natural product biosynthesis
Winter, J. M., & Tang, Y. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.12.016 · Cited by 88 · see citing works
Singh, A. A., & Dwivedi, P. (2018) · Journal of Pharmacognosy and Phytochemistry · Cited by 84 · see citing works
The biochemical basis for the deleterious effects of l-canavanine
Rosenthal, G. A. (1991) · Phytochemistry · doi:10.1016/s0031-9422(00)95170-7 · Cited by 82 · see citing works
Recent developments in the engineering of zinc finger proteins
Moore, M., & Ullman, C. G. (2003) · Briefings in Functional Genomics · doi:10.1093/bfgp/1.4.342 · Cited by 81 · see citing works
Investigations of Vacuoles Isolated from Tobacco
Saunders, J. A. (1979) · PLANT PHYSIOLOGY · doi:10.1104/pp.64.1.74 · Cited by 81 · see citing works
Nejat, N., Valdiani, A., Cahill, D. M., Tan, Y., Mahmood, M., & Abiri, R. (2015) · The Scientific World JOURNAL · doi:10.1155/2015/982412 · Cited by 80 · see citing works
Kang, S.-M., Min, J., Kim, Y., Kang, Y., Park, D.-J., Jung, H., Kim, S.-W., & Choi, M.-S. (2006) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1079/ivp2005719 · Cited by 79 · see citing works
Soybean hairy roots produced in vitro by Agrobacterium rhizogenes-mediated transformation
Chen, L., Cai, Y., Liu, X., Guo, C., Sun, S., Wu, C., Jiang, B., Han, T., & Hou, W. (2017) · The Crop Journal · doi:10.1016/j.cj.2017.08.006 · Cited by 78 · see citing works
Jung, H., Kang, S.-M., Kang, Y., Kang, M., Yun, D., Bahk, J.-D., Yang, J., & Choi, M.-S. (2003) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(03)00253-9 · Cited by 75 · see citing works
Methyl jasmonate represses growth and affects cell cycle progression in cultured Taxus cells
Patil, R. A., Lenka, S. K., Normanly, J., Walker, E. L., & Roberts, S. C. (2014) · Plant Cell Reports · doi:10.1007/s00299-014-1632-5 · Cited by 75 · see citing works
Gioti, E. M., Skalkos, D. C., Fiamegos, Y. C., & Stalikas, C. D. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.038 · Cited by 74 · see citing works
Chodisetti, B., Rao, K. V., Gandi, S., & Giri, A. (2013) · Plant Biotechnology Reports · doi:10.1007/s11816-013-0290-3 · Cited by 74 · see citing works
Kang, S.-M., Min, J., Kim, Y., Karigar, C. S., Kim, S.-W., Goo, G.-H., & Choi, M.-S. (2008) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2008.09.007 · Cited by 74 · see citing works
Awad, V., Kuvalekar, A., & Harsulkar, A. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2013.12.036 · Cited by 74 · see citing works
Sottomayor, M., Cardoso, I. L., Pereira, L. G., & Barceló, A. R. (2004) · Phytochemistry Reviews · doi:10.1023/b:phyt.0000047807.66887.09 · Cited by 72 · see citing works
CATHARANTHUS ROSEUS (L.) G. DON. AN IMPORTANT DRUG: ITS APPLICATIONS AND PRODUCTION
Aslam, J., Khan, S. H., & Siddiqui, Z. H. (2010) · Cited by 70 · see citing works
Crop Improvement: New Approaches and Modern Techniques
Rashıd, B., Tariq, M., Khalid, A., Shams, F., Ali, Q., Ashraf, F., Ghaffar, I., Khan, M. I., Rehman, R., & Husnaın, T. (2017) · Plant Gene and Trait · doi:10.5376/pgt.2017.08.0003 · Cited by 70 · see citing works
Metabolic engineering in plants for human health and nutrition
Kinney, A. J. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.02.006 · Cited by 69 · see citing works
Wu, C., Karioti, A., Rohr, D., Bilia, A. R., & Efferth, T. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.01.054 · Cited by 68 · see citing works
Gutiérrez‐Mañero, F. J., Algar, E., Gómez, M. S. M., Sierra, M. D. S., & Ramos‐Solano, B. (2012) · Pharmaceutical Biology · doi:10.3109/13880209.2012.664150 · Cited by 67 · see citing works
Advancements in the Production of Secondary Metabolites
Vijaya Sree, N., Udayasri, P., & BABU, R. S. (2010) · Cited by 67 · see citing works
Sun, J., & Peebles, C. A. M. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0881-7 · Cited by 66 · see citing works
Mass production of Ajmalicine by bioreactor cultivation of hairy roots of Catharanthus roseus
Thakore, D., Srivastava, A. K., & Sinha, A. K. (2016) · Biochemical Engineering Journal · doi:10.1016/j.bej.2016.12.010 · Cited by 64 · see citing works
Nogueira, T., Marcelo‐Curto, M. J., Figueiredo, A. C., Barroso, J. G., Pedro, L. G., Rubiolo, P., & Bicchi, C. P. (2007) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2007.07.004 · Cited by 63 · see citing works
Perassolo, M., Cardillo, A. B., Mugas, M. L., Montoya, S. C. N., Giulietti, A. M., & Talou, J. R. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.05.010 · Cited by 62 · see citing works
Artemisinin production by plant hairy root cultures in gas- and liquid-phase bioreactors
Patra, N., & Srivastava, A. K. (2015) · Plant Cell Reports · doi:10.1007/s00299-015-1875-9 · Cited by 58 · see citing works
Jasmonates elicit different sets of stilbenes in Vitis vinifera cv. Negramaro cell cultures
Taurino, M., Ingrosso, I., D’Amico, L., Domenico, S. D., Nicoletti, I., Corradini, D., Santino, A., & Giovinazzo, G. (2015) · SpringerPlus · doi:10.1186/s40064-015-0831-z · Cited by 58 · see citing works
Mastan, A., Bharadwaj, R. K. B., Kushwaha, R. K., & Babu, C. S. V. (2019) · Microbial Ecology · doi:10.1007/s00248-019-01376-w · Cited by 57 · see citing works
Almagro, L., Gutierrez, J., Pedreño, M. A., & Sottomayor, M. (2014) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-014-0554-9 · Cited by 54 · see citing works
Zhong, J., & Zhu, Q. (1995) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02786863 · Cited by 53 · see citing works
Thiruvengadam, M., Rekha, K., & Chung, I. (2015) · Scientia Horticulturae · doi:10.1016/j.scienta.2015.11.035 · Cited by 52 · see citing works
Namdeo, A., & Sharma, A. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60062-8 · Cited by 49 · see citing works
Goldhaber-Pasillas, G. D., Mustafa, N. R., & Verpoorte, R. (2014) · Molecules · doi:10.3390/molecules190710242 · Cited by 47 · see citing works
Kim, B. J., Gibson, D. M., & Shuler, M. L. (2005) · Biotechnology Progress · doi:10.1021/bp050016z · Cited by 45 · see citing works
Camptothecin from Nothapodytes nimmoniana: review on biotechnology applications
Isah, T., & Mujib, A. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1854-3 · Cited by 45 · see citing works
Ha, L. T., Jullian, N., Lequart‐Pillon, M., Boitel‐Conti, M., Duong, H. X., & Gontier, É. (2016) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-016-0980-y · Cited by 43 · see citing works
Liu, J., Zhu, J., Le, T., Wen, W., Lv, S., & Yu, R. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1432-z · Cited by 42 · see citing works
Extraction and elemental analysis of Coleus forskohlii extract
Kanne, H., Prasanna, V. K., Burte, N., & Gujjula, R. (2015) · Pharmacognosy Research · doi:10.4103/0974-8490.157966 · Cited by 40 · see citing works
Sharma, K., & Zafar, R. (2016) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2016.02.029 · Cited by 39 · see citing works
Self-citationLi, M., Peebles, C. A. M., Shanks, J. V., & San, K. (2011) · Biotechnology Progress · doi:10.1002/btpr.605 · Cited by 38 · see citing works
Isah, T. (2015) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2015/16293 · Cited by 36 · see citing works
Ogita, S. (2015) · Natural Product Communications · doi:10.1177/1934578x1501000527 · Cited by 35 · see citing works
Variation in the contents of pseudohypericin and hypericin in Hypericum perforatum from Lithuania
Bagdonaitė, E., Mártonfi, P., Repčák, M., & Labokas, J. (2010) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2010.08.005 · Cited by 34 · see citing works
Liang, C., Chen, C., Zhou, P., Xu, L. S., Zhu, J., Liang, J., Zi, J., & Yu, R. (2018) · Molecules · doi:10.3390/molecules23123276 · Cited by 32 · see citing works
Takeuchi, C., Nagatani, K., & Sato, Y. (2013) · Journal of Plant Research · doi:10.1007/s10265-013-0568-0 · Cited by 25 · see citing works
Current Perspectives in microRNAs (miRNA)
Ying, S. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8533-8 · Cited by 20 · see citing works
Gu, Q. (2007) · Zhongguo yaowu huaxue zazhi · Cited by 20 · see citing works
In vitro Production of Secondary Metabolites Using Elicitor in Catharanthus roseus: A Case Study
Siddiqui, Z. H., Mujib, A., Mahmooduzzafar, M., Aslam, J., Hakeem, K. R., & Parween, T. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7028-1_14 · Cited by 18 · see citing works
You, M., Kim, D.-W., Jeong, K.-S., Bang, M., Kim, H.-S., Rhuy, J., & Kim, H. A. (2015) · Nutrition Research and Practice · doi:10.4162/nrp.2015.9.5.459 · Cited by 17 · see citing works
The Use of RNAi to Elucidate and Manipulate Secondary Metabolite Synthesis in Plants
Wagner, G. J., & Kroumova, A. B. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8533-8_23 · Cited by 15 · see citing works
Zhao, C., Song, G., Fu, C., Dong, Y., Xu, H., Zhang, H., & Yu, L. J. (2015) · Plant Cell Reports · doi:10.1007/s00299-015-1902-x · Cited by 14 · see citing works
Naz, S. (2015) · Pakistan Journal of Pharmaceutical Sciences · doi:10.36721/pjps/28/3/2015/2645/849-853 · Cited by 9 · see citing works
Flagged first, then by citations
3 of the 147 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- [44]Gorelick J. Bernstein N. Elicitation: An underutilized tool in the development of medicinal plants as a source of therapeutic secondary metabolites Sparks D.L. Advances in Agronomy 124 2014 Elsevier Amsterdam, The Netherlands 201 230
- [71]Latchman D.S. Eucaryotic transcription factors 2003 Academic Press San Diego
- [115]Naeem M. Aftab T. Masroor K.M.A. Catharanthus Roseus. Current Research and Future Prospects 2017 Springer India 412 10.1007/978-3-319-51620-2 · DOI
- [138]Jordan A. Hadfield J.A. Lawrence N.J. McGown A.T. Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle Med. Res Rev. 18 1998 259 296 9664292
- [143]Christen A.A. Bland J. Gibson G.M. Cell cultures as a means to produce taxol Proc. Amer. Assoc. Canc. Res. 30 1989 566
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Meena, M., Swapnil, P., Divyanshu, K., Kumar, S., Mangesh, H., Tripathi, Y. N., Zehra, A., Marwal, A., & Upadhyay, R. S. (2020) · Journal of Basic Microbiology · doi:10.1002/jobm.202000370 · Cited by 388 · see citing works
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García-Pérez, P., Lozano-Milo, E., Landín, M., & Gallego, P. P. F. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.576177 · Cited by 28 · see citing works
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Banadka, A., Sudheer, W. N., Dandin, V. S., Naik, P. M., Vennapusa, A. R., Melmaiee, K., Vemanna, R. S., Al-Khayri, J. M., Thiruvengadam, M., & Nagella, P. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-024-13187-2 · Cited by 27 · see citing works
Acharjee, S., Kumar, R., & Kumar, N. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.114298 · Cited by 26 · see citing works
Biological control of plant diseases by endophytes
Yadav, G., & Meena, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91245-7.00007-9 · Cited by 25 · see citing works
Self-citationPrashant, S. P., & Mishra, B. (2024) · Physiologia Plantarum · doi:10.1111/ppl.14400 · Cited by 25 · see citing works
Pandino, G., Bonomo, A., Scavo, A., Mauromicale, G., & Lombardo, S. (2022) · Scientia Horticulturae · doi:10.1016/j.scienta.2022.111180 · Cited by 25 · see citing works
Qahtan, A. A., Faisal, M., Alatar, A. A., & Abdel-Salam, E. M. (2022) · Plants · doi:10.3390/plants11121614 · Cited by 25 · see citing works
Antioxidant Green Factories: Toward Sustainable Production of Vitamin E in Plant In Vitro Cultures
Muthulakshmi, M., Srinivasan, A., & Srivastava, S. (2023) · ACS Omega · doi:10.1021/acsomega.2c05819 · Cited by 27 · see citing works
Rezaei, H., Mirzaie-Asl, A., Abdollahi, M. R., & Tohidfar, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285657 · Cited by 25 · see citing works
Żbik, K., Onopiuk, A., Szpicer, A., & Kurek, M. A. (2023) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-023-02158-2 · Cited by 25 · see citing works
Gómez‐Ramos, G. A., Prado‐Barragán, L. A., Rivera, B. A., Huerta‐Ochoa, S., Rivera, V. M., Couder‐García, M., García‐Hernández, R. D. L. Á., & Castillo-Araiza, C. O. (2024) · Chemical Engineering & Technology · doi:10.1002/ceat.202400289 · Cited by 24 · see citing works
Javed, R., Yücesan, B., Zia, M., & Gürel, E. (2022) · Springer eBooks · doi:10.1007/978-981-19-2503-0_10 · Cited by 24 · see citing works
A review: improvement of plant tissue culture applications by using nanoparticles
Balamurugan, V., Abdi, G., Karthiksaran, C., Nedumaran, T., & Dhanarajan, A. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-024-06103-2 · Cited by 23 · see citing works
Collection of Hairy Roots as a Basis for Fundamental and Applied Research
Stepanova, A. Y., Malunova, M. V., Gladkov, E. A., Evsyukov, S. V., Tereshonok, D. V., & Соловьева, А. И. (2022) · Molecules · doi:10.3390/molecules27228040 · Cited by 23 · see citing works
Golkar, P., Akbari, R., Bazarganipour, M., & Javed, R. (2023) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2023.107741 · Cited by 23 · see citing works
Zahid, M., Khalid, S., Raana, S., Amin, S., Javaid, H., Arshad, R., Jahangeer, A., Ahmad, S., & Hassan, S. A. (2024) · Future Foods · doi:10.1016/j.fufo.2024.100328 · Cited by 22 · see citing works
Mueangnak, K., Kitwetcharoen, H., Thanonkeo, P., Klanrit, P., Apiraksakorn, J., Klanrit, P., Klanrit, P., & Thanonkeo, P. (2025) · Scientific Reports · doi:10.1038/s41598-024-83096-x · Cited by 21 · see citing works
Enhanced Secondary Metabolite Production in Hairy Root Cultures Through Biotic and Abiotic Elicitors
Kaur, G., Prakash, P., Srivastava, R., & Verma, P. C. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-30185-9_38 · Cited by 21 · see citing works
Niazian, M., Howyzeh, M. S., & Sadat-Noori, S. A. (2021) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-021-02096-1 · Cited by 20 · see citing works
Sustainable Production of Ajuga Bioactive Metabolites Using Cell Culture Technologies: A Review
Popova, E., Титова, М. В., Тыныкулов, М., Zakirova, R. P., Куличенко, И. Е., Prudnikova, O. N., & Nosov, A. M. (2023) · Nutrients · doi:10.3390/nu15051246 · Cited by 20 · see citing works
Makowski, W., Królicka, A., Tokarz, B., Szopa, A., Ekiert, H., & Tokarz, K. M. (2023) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-023-02487-6 · Cited by 20 · see citing works
Zayed, A., Farag, M. A., Mehring, A., Salem, M. A., Ibrahim, R. M., Alseekh, S., Fernie, A. R., & Ulber, R. (2023) · Phytochemistry · doi:10.1016/j.phytochem.2023.113777 · Cited by 20 · see citing works
Suspension culture of somatic embryos for the production of high-value secondary metabolites
Murthy, H. N., Joseph, K. S., Hahn, J.-E., Lee, H.-S., Paek, K., & Park, S. (2023) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-023-01365-x · Cited by 20 · see citing works
Bansal, Y., Mujib, A., Mamgain, J., Syeed, R., Mohsin, M., Nafees, A., Dewir, Y. H., & Mendler‐Drienyovszki, N. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1433634 · Cited by 19 · see citing works
Deciphering nutrient stress in plants: integrative insight from metabolomics and proteomics
Moshood, A. Y., Abdulraheem, M. I., Li, L., Zhang, Y., Raghavan, V., & Hu, J. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01551-y · Cited by 20 · see citing works
Haida, Z., Sinniah, U. R., Nakasha, J. J., & Hakiman, M. (2022) · Horticulturae · doi:10.3390/horticulturae8080740 · Cited by 19 · see citing works
Ji, B., Xuan, L., Zhang, Y., Mu, W., Paek, K., Park, S., Wang, J., & Gao, W. (2023) · Plants · doi:10.3390/plants12071505 · Cited by 19 · see citing works
Kaur, J., Dhar, S. K., Chauhan, A., Yadav, S., Mudgal, G., Asyakina, L. K., Atuchin∥⊥, V. V., & Abdi, G. (2023) · Current Plant Biology · doi:10.1016/j.cpb.2023.100308 · Cited by 20 · see citing works
Hagaggi, N. S. A., Abdul-Raouf, U. M., & Radwan, T. A. A. (2024) · BMC Plant Biology · doi:10.1186/s12870-024-04747-9 · Cited by 19 · see citing works
Lescano, L., Cziáky, Z., Custódio, L. M. B., & Rodrigues, M. J. (2025) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-025-02991-x · Cited by 18 · see citing works
Halder, M., Majumder, A., Ray, S., & Jha, S. (2021) · Sustainable development and biodiversity · doi:10.1007/978-3-030-74779-4_16 · Cited by 18 · see citing works
Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy
Sevastre, A.-S., Manea, E. V., Popescu, Ş. O., Tache, D. E., Dănoiu, S., Sfredel, V., Tătăranu, L. G., & Dricu, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179943 · Cited by 18 · see citing works
Sharma, A., Pandey, H., Devadas, V. A. S. N., Kartha, B. D., & Jha, R. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08162 · Cited by 18 · see citing works
Roshni, P. T., & Rekha, P. D. (2024) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-024-01426-9 · Cited by 18 · see citing works
Nanoparticle-assisted elicitation of therapeutically important secondary metabolites in plants
Vyavahare, G. D., Patil, R. R., & Park, J. H. (2025) · Plant Growth Regulation · doi:10.1007/s10725-025-01388-2 · Cited by 17 · see citing works
Nano-Elicitation Approaches for Boosting Secondary Metabolites in Medicinal Plant Cell Cultures
Golkar, P., Vázquez-Núñez, E., & Peralta-Videa, J. R. (2025) · Plants · doi:10.3390/plants15010046 · Cited by 17 · see citing works
Nomura, T., Yoneda, A., Ogita, S., & Kato, Y. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03629-2 · Cited by 17 · see citing works
Purification and characterisation of uricase from Bacillus subtilis SP6
Pustake, S. O., Bhagwat, P. K., Pillai, S., & Dandge, P. B. (2021) · Process Biochemistry · doi:10.1016/j.procbio.2021.12.010 · Cited by 17 · see citing works
- Authors
- Chandran, H., Meena, M., Barupal, T., & Sharma, K.
- Affiliations
- Mohanlal Sukhadia University (IN)
- Corresponding author
- Meena, Mukesh
- Venue
- Biotechnology Reports
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 26
- Pages
- e00450
- ISSN
- 2215-017X (ISSN-L)
- PMC
- PMC7193120
- OpenAlex
- W3019219369
- Cited by
- 462
- References
- 147
- Citations by year
- 2026: 44 · 2025: 78 · 2024: 92 · 2023: 102 · 2022: 83 · 2021: 52 · 2020: 11
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biotechnology Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University Grants Committee
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
- Keywords
- plant tissue culture, secondary metabolites, bioactive compounds, bioreactors, mass production, medicinal plants, phytochemicals
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