Effects of Scn Lesions on Orcadian Blood Pressure Rhythm in Normotensive and Transgenic Hypertensive Rats
Abstract
Transgenic hypertensive TGR(mREN2)27 (TGR) rats, carrying an additional mouse renin gene, have been found to show inverse circadian blood pressure profiles compared to normotensive Sprague-Dawley rats. In order to evaluate the contributions of the suprachiasmatic nucleus (SCN) and the neurohormone melatonin to cardiovascular circadian regulation in TGR(mREN2)27 rats and Sprague-Dawley (SPRD) controls, we investigated the effects of melatonin agonist and antagonist treatment in SCN-lesioned and nonlesioned rats, which were kept under conditions of alternating light and darkness (LD). After destruction of the SCN, circadian rhythmicity in blood pressure, heart rate (HR), and motor activity (MA) was almost abolished in rats of both strains. One week of treatment with a synthetic melatonin agonist S-21634 was not able to restore circadian variation in the parameters monitored. In nonlesioned TGR(mREN2)27 rats and Sprague-Dawley control rats, the melatonin antagonist S-22365 had no suppressive effect on LD-synchronized circadian rhythmicity, indicating that LD itself may have a stronger influence on the SCN than endogenous melatonin.
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In rodents, lesions of the suprachiasmatic nucleus abolish or attenuate daily rhythms in locomotor activity, body temperature, blood pressure, and heart rate, showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.
“In rodents, lesions of the SCN abolish or attenuate daily rhythms in locomotor activity, body temperature, BP, and HR (22)(23)(24), showing that these rhythms are endogenous rather than resulting from daily changes in behavior or environment.”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [24]
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- Authors
- Witte, K., Schnecko, A., Buijs, R. M., van der Vliet, J., Scalbert, E., Delagrange, P., Guardiola-Lemaitre, B., & Lemmer, B.
- Affiliations
- Heidelberg University (DE)
- Institut de Recherches Internationales Servier (France) (FR)
- Corresponding author
- Lemmer, B.
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 1998-01
- Volume
- 15
- Issue
- 2
- Pages
- 135-145
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2099890761
- Cited by
- 90
- References
- 24
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 7
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- suprachiasmatic nucleus, SCN lesions, circadian blood pressure rhythm, melatonin, melatonin receptor agonists, heart rate, motor activity, light-dark cycle, circadian regulation
- MeSH terms
- Animals, Blood Pressure, Circadian Rhythm, Darkness, Heart Rate, Heterozygote, Hypertension, Light, Male, Melatonin, Motor Activity, Renin, Suprachiasmatic Nucleus, Rats, Sprague-Dawley, Animals, Genetically Modified, Mice, Rats
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