Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation
Open accessAbstract
As the central pacemaker, the suprachiasmatic nucleus (SCN) has long been considered the primary regulator of blood pressure circadian rhythm; however, this dogma has been challenged by the discovery that each of the clock genes present in the SCN is also expressed and functions in peripheral tissues. The involvement and contribution of these peripheral clock genes in the circadian rhythm of blood pressure remains uncertain. Here, we demonstrate that selective deletion of the circadian clock transcriptional activator aryl hydrocarbon receptor nuclear translocator-like (Bmal1) from smooth muscle, but not from cardiomyocytes, compromised blood pressure circadian rhythm and decreased blood pressure without affecting SCN-controlled locomotor activity in murine models. In mesenteric arteries, BMAL1 bound to the promoter of and activated the transcription of Rho-kinase 2 (Rock2), and Bmal1 deletion abolished the time-of-day variations in response to agonist-induced vasoconstriction, myosin phosphorylation, and ROCK2 activation. Together, these data indicate that peripheral inputs contribute to the daily control of vasoconstriction and blood pressure and suggest that clock gene expression outside of the SCN should be further evaluated to elucidate pathogenic mechanisms of diseases involving blood pressure circadian rhythm disruption.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Targeted deletion of Bmal1 in murine vascular smooth muscle cells blunts the circadian amplitudes and advances the circadian phases of systolic and diastolic blood pressure, and abolishes the circadian variation of pulse pressure.
“Functionally, targeted deletion of Bmal1 in murine vascular smooth muscle cells blunts the circadian amplitudes and advances the circadian phases of systolic and diastolic BP, and abolishes the circadian variation of pulse pressure (70).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329 · see citing works
Signal transduction and regulation in smooth muscle
Somlyo, A. P., & Somlyo, A. V. (1994) · Nature · doi:10.1038/372231a0 · Cited by 1,923 · see citing works
Circadian variation of blood-pressure
Millar-Craig, M., Bishop, C., & Raftery, E. B. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92998-7 · Cited by 1,293 · see citing works
Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188 · see citing works
Physiology of Circadian Entrainment
Golombek, D. A., & Rosenstein, R. E. (2010) · Physiological Reviews · doi:10.1152/physrev.00009.2009 · Cited by 1,103 · see citing works
Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976 · see citing works
Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865 · see citing works
Sohal, D. S., Nghiem, M. P., Crackower, M. A., Witt, S. A., Kimball, T. R., Tymitz, K. M., Penninger, J. M., & Molkentin, J. D. (2001) · Circulation Research · doi:10.1161/hh1301.092687 · Cited by 697 · see citing works
Circadian Variation in the Timing of Stroke Onset: A Meta-analysis
Elliott, W. J. (1998) · Stroke · doi:10.1161/01.str.29.5.992 · Cited by 638 · see citing works
ATMOSPHERIC OZONE AND FEMORAL FRACTURES
Burton, J. L., Ensell, F. J., Leach, J. F., & Hall, K. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92450-2 · Cited by 587 · see citing works
Meta-Analysis of the Morning Excess of Acute Myocardial Infarction and Sudden Cardiac Death
Cohen, M. C., Rohtla, K. M., Lavery, C. E., Muller, J. E., & Mittleman, M. A. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00181-1 · Cited by 534 · see citing works
Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine
Shimokawa, H., & Takeshita, A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000176193.83629.c8 · Cited by 482 · see citing works
Storch, K.-F., Paz, C., Signorovitch, J., Raviola, E., Pawlyk, B., Li, T., & Weitz, C. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.045 · Cited by 460 · see citing works
Verdecchia, P., Schillaci, G., Borgioni, C., Ciucci, A., Pede, S., & Porcellati, C. (1998) · Hypertension · doi:10.1161/01.hyp.32.6.983 · Cited by 402 · see citing works
Circadian variation of blood pressure and the vascular response to asynchronous stress
Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 401 · see citing works
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
McCurley, A., Pires, P. W., Bender, S. B., Aronovitz, M. A., Zhao, M. J., METZGER, D., Chambon, P., Hill, M. A., Dorrance, A. M., Mendelsohn, M. E., et al. (2012) · Nature Medicine · doi:10.1038/nm.2891 · Cited by 349 · see citing works
Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice
McDearmon, E. L., Patel, K., Ko, C. H., Walisser, J. A., Schook, A. C., Chong, J. L., Wilsbacher, L. D., Song, E. J., Hong, H., Bradfield, C. A., et al. (2006) · Science · doi:10.1126/science.1132430 · Cited by 321 · see citing works
Pulse Pressure and Cardiovascular Disease–Related Mortality
DOMANSKI, M. J., Mitchell, G. F., Pfeffer, M. A., Neaton, J. D., Norman, J. E., Svendsen, K. H., Grimm, R. H., Cohen, J. D., & Stamler, J. (2002) · JAMA · doi:10.1001/jama.287.20.2677 · Cited by 310 · see citing works
Rienzo, M. D., Parati, G., Castiglioni, P., Tordi, R., Mancia, G., & Pedotti, A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.3.r744 · Cited by 293 · see citing works
Gong, M. C., Cohen, P., Kitazawa, T., Ikebe, M., Masuo, M., Somlyo, A. P., & Somlyo, A. V. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42092-3 · Cited by 210 · see citing works
Self-citationProgressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus
Bunger, M. K., Walisser, J. A., Sullivan, R., Manley, P. A., Moran, S. M., Kalscheur, V. L., Colman, R. J., & Bradfield, C. A. (2005) · genesis · doi:10.1002/gene.20102 · Cited by 207 · see citing works
The cardiomyocyte molecular clock, regulation of <i>Scn5a</i> , and arrhythmia susceptibility
Schroder, E. A., Lefta, M., Zhang, X., Bartos, D. C., Feng, H.-Z., Zhao, Y., Patwardhan, A., Jin, J.-P., Esser, K. A., & Delisle, B. P. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00383.2012 · Cited by 147 · see citing works
Self-citationGuo, Z., Su, W., ALLEN, S., PANG, H., Daugherty, A., Smart, E. J., & Gong, M. C. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.008 · Cited by 143 · see citing works
Self-citationPulse pressure and risk of cardiovascular events in the systolic hypertension in the elderly program
Vaccarino, V., Berger, A. K., Abramson, J. L., Black, H. R., Setaro, J. F., Davey, J. A., & Krumholz, H. M. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01974-9 · Cited by 136 · see citing works
Ivanov, P. C., Hu, K., Hilton, M. F., Shea, S. A., & Stanley, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709957104 · Cited by 125 · see citing works
Hypertension and disrupted blood pressure circadian rhythm in Type 2 diabetic db/db mice
Su, W., Guo, Z., Randall, D. C., Cassis, L. A., Brown, D. R., & Gong, M. C. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00257.2008 · Cited by 118 · see citing works
Self-citationPeripheral Circadian Clocks in the Vasculature
Reilly, D. F., Westgate, E. J., & FitzGerald, G. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.144923 · Cited by 115 · see citing works
Ambulatory pulse pressure aspredictor of outcome in older patients with systolic hypertension
Staessen, J. A. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02987-4 · Cited by 103 · see citing works
Pelham, C. J., Ketsawatsomkron, P., Groh, S., Grobe, J. L., de Lange, W. J., Ibeawuchi, S., Keen, H. L., Weatherford, E. T., Faraci, F. M., & Sigmund, C. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.011 · Cited by 100 · see citing works
Reactivity of Ambulatory Blood Pressure to Physical Activity Varies With Time of Day
Jones, H., Atkinson, G., Leary, A., George, K., Murphy, M., & Waterhouse, J. (2006) · Hypertension · doi:10.1161/01.hyp.0000206421.09642.b5 · Cited by 96 · see citing works
Circadian rhythm of baroreflex reactivity and adrenergic vascular response
Hossmann, V., FitzGerald, G. A., & Dollery, C. T. (1980) · Cardiovascular Research · doi:10.1093/cvr/14.3.125 · Cited by 92 · see citing works
Witte, K., Schnecko, A., Buijs, R. M., van der Vliet, J., Scalbert, E., Delagrange, P., Guardiola-Lemaitre, B., & Lemmer, B. (1998) · Chronobiology International · doi:10.3109/07420529808998678 · Cited by 90 · see citing works
Su, W., Xie, Z., Guo, Z., Duncan, M. J., Lutshumba, J., & Gong, M. C. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00825.2011 · Cited by 78 · see citing works
Self-citationMasuki, S., Todo, T., Nakano, Y., Okamura, H., & Nosé, H. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086728 · Cited by 76 · see citing works
Xie, Z., Su, W., Guo, Z., PANG, H., Post, S. R., & Gong, M. C. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.002 · Cited by 68 · see citing works
Self-citationChang, L., Villacorta, L., Zhang, J., Garcia-Barrio, M. T., Yang, K., Hamblin, M., Whitesall, S. E., D’Alecy, L. G., & Chen, Y. E. (2009) · Circulation · doi:10.1161/circulationaha.108.815803 · Cited by 67 · see citing works
Generation of an Adult Smooth Muscle Cell–Targeted Cre Recombinase Mouse Model
Zhang, J., Zhong, W., Cui, T., Yang, M., Hu, X., Xu, K., Xie, C., Xue, C., Gibbons, G. H., Liu, C., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000202661.61837.93 · Cited by 62 · see citing works
Pang, H., Guo, Z., Su, W., Xie, Z., Eto, M., & Gong, M. C. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00111.2005 · Cited by 61 · see citing works
Self-citationXie, Z., Liu, D., Liu, S., Cormier, L. E., Zhao, G., TURK, J. W., & Guo, Z. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.265462 · Cited by 59 · see citing works
Self-citationXie, Z., Gong, M. C., Su, W., Xie, D., TURK, J. W., & Guo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057711 · Cited by 53 · see citing works
Self-citationThomas, F., Blacher, J., Bénétos, A., Safar, M. E., & Pannier, B. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282fcc22b · Cited by 52 · see citing works
Guo, Z., Su, W., Ma, Z., Smith, G. M., & Gong, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211075200 · Cited by 50 · see citing works
Self-citationXie, Z., Gong, M. C., Su, W., TURK, J. W., & Guo, Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611206200 · Cited by 44 · see citing works
Self-citationTwenty-Four-Hour Variations in the Sensitivity of Rat Aorta to Vasoactive Agents
Keskil, Z. A., Görgün, C. Z., Hodoğlugil, U., & Zengil, H. (1996) · Chronobiology International · doi:10.3109/07420529609020917 · Cited by 43 · see citing works
Saito, T., Hirano, M., Ide, T., Ichiki, T., Koibuchi, N., Sunagawa, K., & Hirano, K. (2012) · Circulation · doi:10.1161/circulationaha.112.135608 · Cited by 41 · see citing works
Su, W., Xie, Z., Liu, S., Cormier, L. E., Guo, Z., & Gong, M. C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00597.2012 · Cited by 34 · see citing works
Self-citationPulse Pressure, Prehypertension, and Mortality: The San Antonio Heart Study
Lorenzo, C., Aung, K., D, M. P. S. M., & Haffner, S. M. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.151 · Cited by 32 · see citing works
Pang, H., Guo, Z., Xie, Z., Su, W., & Gong, M. C. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00378.2005 · Cited by 20 · see citing works
Self-citationUltradian variations in sensitivity of rat aorta rings to noradrenaline
Gohar, M., Daleau, P., Atkinson, J., & Gargouïl, Y. M. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90287-e · Cited by 17 · see citing works
Witte, K. K., Hasenberg, T., Rueff, T., Hauptfleisch, S., Schilling, L., & Lemmer, B. (2001) · Chronobiology International · doi:10.1081/cbi-100106080 · Cited by 16 · see citing works
Görgün, C. Z., Keskil, Z. A., Hodoğlugil, U., Ercan, Z. S., Abacıoğlu, N., & Zengil, H. (1998) · Chronobiology International · doi:10.3109/07420529808998668 · Cited by 15 · see citing works
Circadianicity of hemostatic function and coronary vasomotion.
Andreotti, F., Luca, L. D., Renda, G., Ferro, A., Mongiardo, R., ZECCHI, P., & Maseri, A. (1999) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Su W, Xie Z, Guo Z, Duncan MJ, Lutshumba J, Gong MC. Altered clock gene expression and vascular smooth muscle diurnal contractile vari- ations in type 2 diabetic db/db mice. Am J Physiol Heart Circ Physiol. 2012;302(3):H621-H633.
- Golombek DA, Rosenstein RE. Physiol- ogy of circadian entrainment. Physiol Rev. 2010;90(3):1063-1102.
- Schroder EA, et al. The cardiomyocyte molecu- lar clock, regulation of Scn5a, and arrhyth- mia susceptibility. Am J Physiol Cell Physiol. 2013;304(10):C954-C965.
- Xie Z, Gong MC, Su W, Xie D, Turk J, Guo Z. Role of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hyper- contractility in diabetic animals. J Biol Chem. 2010;285(12):8628-8638.
Cited by
Sorted by citations
Bharath, L. P., Agrawal, M., McCambridge, G., Nicholas, D. A., Hasturk, H., Liu, J., Jiang, K., Liu, R., Guo, Z., Deeney, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.015 · Cited by 614 · see citing works
Self-citationCircadian rhythms and the molecular clock in cardiovascular biology and disease
Crnko, S., Du Pré, B. C., Sluijter, J. P. G., & Van Laake, L. W. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0167-4 · Cited by 499 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease
Hartmann, S., Ridley, A. J., & Lutz, S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00276 · Cited by 357 · see citing works
Circadian clock-mediated regulation of blood pressure
Douma, L. G., & Gumz, M. L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.024 · Cited by 267 · see citing works
Circadian rhythms and the kidney
Firsov, D., & Bonny, O. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0048-9 · Cited by 217 · see citing works
Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells
Chang, L., Garcia-Barrio, M. T., & Chen, Y. E. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.312464 · Cited by 162 · see citing works
Recent advances in circadian rhythms in cardiovascular system
Chen, L., & Yang, G. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00071 · Cited by 157 · see citing works
Beytebiere, J. R., Trott, A. J., Greenwell, B. J., Osborne, C. A., Vitet, H., Spence, J., Yoo, S. H., Chen, Z., Takahashi, J. S., Ghaffari, N., et al. (2019) · Genes & Development · doi:10.1101/gad.322198.118 · Cited by 151 · see citing works
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension
Costello, H. M., & Gumz, M. L. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.14519 · Cited by 145 · see citing works
Off the Clock: From Circadian Disruption to Metabolic Disease
Maury, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071597 · Cited by 142 · see citing works
A human embryonic limb cell atlas resolved in space and time
Zhang, B., He, P., Lawrence, J. E. G., Wang, S., Tuck, E., Williams, B. A., Roberts, K., Kleshchevnikov, V., Mamanova, L., Bolt, L., et al. (2024) · Nature · doi:10.1038/s41586-023-06806-x · Cited by 143 · see citing works
Circadian Influence on Metabolism and Inflammation in Atherosclerosis
McAlpine, C. S., & Świrski, F. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.308034 · Cited by 138 · see citing works
Pan, X., Bradfield, C. A., & Hussain, M. M. (2016) · Nature Communications · doi:10.1038/ncomms13011 · Cited by 132 · see citing works
Rethinking pioglitazone as a cardioprotective agent: a new perspective on an overlooked drug
Nesti, L., Tricò, D., Mengozzi, A., & Natali, A. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01294-7 · Cited by 125 · see citing works
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease
Alibhai, F. J., LaMarre, J., Reitz, C. J., Tsimakouridze, E. V., Kroetsch, J. T., Bolz, S., Shulman, A., Steinberg, S., Burris, T. P., Oudit, G. Y., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.01.008 · Cited by 123 · see citing works
Circadian Clock Regulates Bone Resorption in Mice
Xu, C., Ochi, H., Fukuda, T., Sato, S., Sunamura, S., Takarada, T., Hinoi, E., Okawa, A., & Takeda, S. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2803 · Cited by 117 · see citing works
Chang, L., Xiong, W., Zhao, X., Fan, Y., Guo, Y., Garcia-Barrio, M. T., Zhang, J., Jiang, Z., Lin, J. D., & Chen, Y. (2018) · Circulation · doi:10.1161/circulationaha.117.029972 · Cited by 113 · see citing works
Chronobiological Influence Over Cardiovascular Function
Rana, S., Prabhu, S. D., & Young, M. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.313349 · Cited by 99 · see citing works
Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis
Man, A. W. C., Li, H., & Xia, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020676 · Cited by 91 · see citing works
Circadian regulation of renal function
Johnston, J. G., & Pollock, D. M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.018 · Cited by 91 · see citing works
ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements
Seccia, T. M., Rigato, M., Ravarotto, V., & Calò, L. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051328 · Cited by 89 · see citing works
A New Perspective for Parkinson’s Disease: Circadian Rhythm
Li, S., Wang, Y., Wang, F., Hu, L., & Liu, C. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0089-7 · Cited by 86 · see citing works
Teng, Y., Li, D., Guruvaiah, P., Xu, N., & Xie, Z. (2018) · Nutrients · doi:10.3390/nu10010075 · Cited by 84 · see citing works
Self-citationCircadian clock and the onset of cardiovascular events
Takeda, N., & Maemura, K. (2016) · Hypertension Research · doi:10.1038/hr.2016.9 · Cited by 80 · see citing works
Consequences of Circadian Disruption on Neurologic Health
Videnović, A., & Zee, P. C. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.004 · Cited by 75 · see citing works
Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure
Faraci, F. M., & Scheer, F. A. J. L. (2024) · Circulation Research · doi:10.1161/circresaha.124.323515 · Cited by 80 · see citing works
Sleep disorders, nocturnal blood pressure, and cardiovascular risk: A translational perspective
Silvani, A. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.02.006 · Cited by 68 · see citing works
Crislip, G. R., Douma, L. G., Masten, S., Cheng, K., Lynch, I. J., Johnston, J. G., Barral, D., Glasford, K., Holzworth, M. R., Verlander, J. W., et al. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00014.2020 · Cited by 67 · see citing works
Metabolic implications of circadian disruption
Fatima, N., & Rana, S. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02381-6 · Cited by 71 · see citing works
Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure
Zhang, D., Colson, J. C., Jin, C., Becker, B., Rhoads, M. K., Pati, P., Neder, T. H., King, M. A., Valcin, J. A., Tao, B., et al. (2020) · Function · doi:10.1093/function/zqaa034 · Cited by 66 · see citing works
Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease
Zhang, J., Sun, R., Jiang, T., Yang, G., & Chen, L. (2021) · Biomolecules · doi:10.3390/biom11060868 · Cited by 55 · see citing works
Shimokawa, H., & Satoh, K. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305353 · Cited by 55 · see citing works
Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice
Hou, T., Su, W., Duncan, M. J., Vsevolozhskaya, O. A., Guo, Z., & Gong, M. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015873118 · Cited by 57 · see citing works
Self-citationZhang, D., Jin, C., Obi, I. E., Rhoads, M. K., Soliman, R. H., Sedaka, R. S., Allan, J. M., Tao, B., Speed, J. S., Pollock, J. S., et al. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00364.2019 · Cited by 52 · see citing works
Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms
Lutshumba, J., Liu, S., Zhong, Y., Hou, T., Daugherty, A., Lu, H. S., Guo, Z., & Gong, M. C. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310153 · Cited by 50 · see citing works
Self-citationRegulation of vascular function and blood pressure by circadian variation in redox signalling
Rodrigo, G. C., & Herbert, K. E. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.381 · Cited by 44 · see citing works
Pati, P., Fulton, D. J., Bagi, Z. A., Chen, F., Wang, Y., Kitchens, J., Cassis, L. A., Stepp, D. W., & Rudic, R. D. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06194 · Cited by 43 · see citing works
Rahman, A., Hasan, A. U., Nishiyama, A., & Kobori, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020400 · Cited by 38 · see citing works
Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion
Johnston, J. G., Speed, J. S., Becker, B., Kasztan, M., Soliman, R. H., Rhoads, M. K., Tao, B., Jin, C., Geurts, A. M., Hyndman, K. A., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.13908 · Cited by 38 · see citing works
Liu, Y., Wu, Z., Cheng, L., Zhang, X., & Yang, H. (2021) · Food & Function · doi:10.1039/d1fo01091c · Cited by 37 · see citing works
Wu, G., Cheng, H., Guo, H., Li, Z., Li, D., & Xie, Z. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109349 · Cited by 36 · see citing works
Self-citationPeripheral Circadian Oscillators.
Brown, A. J., Pendergast, J. S., & Yamazaki, S. (2019) · PubMed Central · Cited by 36 · see citing works
The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms
Engeland, W. C., Massman, L., Mishra, S., Yoder, J. M., Leng, S., Pignatti, E., Piper, M. E., Carlone, D. L., Breault, D. T., & Kofuji, P. (2018) · Endocrinology · doi:10.1210/en.2018-00769 · Cited by 34 · see citing works
Csoma, B., & Bikov, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814145 · Cited by 33 · see citing works
Hou, T., Su, W., Guo, Z., & Gong, M. C. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418803719 · Cited by 31 · see citing works
Self-citationThe role of circadian clock gene BMAL1 in vascular proliferation
Takaguri, A., Sasano, J., Akihiro, O., & Satoh, K. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172924 · Cited by 31 · see citing works
Clock Gene Bmal1 Disruption in Vascular Smooth Muscle Cells Worsens Carotid Atherosclerotic Lesions
Lin, C., Xu, L., Tang, X., Li, X., Lu, C., Cheng, Q., Jiang, J., Shen, Y., Yan, D., Qian, R., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316480 · Cited by 32 · see citing works
Zhang, Y., Gu, M., Wang, R., Li, M., Li, D., & Xie, Z. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-0433-9 · Cited by 29 · see citing works
Self-citationShen, Y., Xu, L., Dong, Y., Zhou, M., Han, T., Lü, C., Tang, X., Lin, C., Qian, R., & Guo, D. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166450 · Cited by 31 · see citing works
Wu, G., Sun, X., Cheng, H., Xu, S., Li, D., & Xie, Z. (2022) · Foods · doi:10.3390/foods11111638 · Cited by 29 · see citing works
Self-citationChen, L., Zhang, B., Yang, L., Bai, Y., Song, J.-B., Ge, Y., Ma, H., Cheng, J., Ma, J., & Xie, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163947 · Cited by 28 · see citing works
Circadian Regulation of Blood Pressure: of Mice and Men
Rhoads, M. K., Balagee, V., & Thomas, S. J. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01043-3 · Cited by 29 · see citing works
Shang, X., Pati, P., Anea, C. B., Fulton, D. J., & Rudic, R. D. (2016) · Journal of Vascular Research · doi:10.1159/000452410 · Cited by 28 · see citing works
Circadian Effects on Vascular Immunopathologies
Zeng, Q., Oliva, V. M., Moro, M. Á., & Scheiermann, C. (2024) · Circulation Research · doi:10.1161/circresaha.123.323619 · Cited by 27 · see citing works
Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors
Zhang, D., & Pollock, D. M. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034446 · Cited by 27 · see citing works
Zhang, J., Liu, C., Liang, Q. L., Zheng, F., Guan, Y., Yang, G., & Chen, L. (2020) · The FASEB Journal · doi:10.1096/fj.202002452r · Cited by 27 · see citing works
Lecour, S., du Pré, B. C., Bøtker, H. E., Brundel, B. J. J. M., Daiber, A., Davidson, S. M., Ferdinandy, P., Girão, H., Gollmann‐Tepeköylü, C., Gyöngyösi, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab293 · Cited by 28 · see citing works
Auerbach, B. J., FitzGerald, G. A., & Li, M. (2022) · Nature Communications · doi:10.1038/s41467-022-34185-w · Cited by 25 · see citing works
Costello, H. M., Crislip, G. R., Cheng, K., Lynch, I. J., Juffre, A., Bratanatawira, P., McKee, A. R., Thelwell, R. S., Mendez, V. M., Wingo, C. S., et al. (2023) · Function · doi:10.1093/function/zqad001 · Cited by 24 · see citing works
Guruvaiah, P., Guo, H., Li, D., & Xie, Z. (2018) · Nutrients · doi:10.3390/nu10091276 · Cited by 24 · see citing works
Self-citationWang, R., Xiao, M., Zhang, Y., Ho, C., Wan, X., Li, D., & Xie, Z. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05057 · Cited by 24 · see citing works
Self-citationPati, P., Valcin, J. A., Zhang, D., Neder, T. H., Millender-Swain, T., Allan, J. M., Sedaka, R. S., Jin, C., Becker, B., Pollock, D. M., et al. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00128.2020 · Cited by 24 · see citing works
Disruptions of Circadian Rhythms and Thrombolytic Therapy During Ischemic Stroke Intervention
Liu, J. A., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.675732 · Cited by 23 · see citing works
Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressure
Wang, Z., Mu, W., Zhong, J., Xu, R., Liu, Y., Zhao, G., Guo, Y., Zhang, J., Surakka, I. L., Chen, Y. E., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci183409 · Cited by 22 · see citing works
Self-citationAHR canonical pathway: in vivo findings to support novel antihypertensive strategies
Coelho, N. R., Matos, C., Pimpão, A. B., Correia, M. J., Sequeira, C. O., Morelló, J., Pereira, S. A., & Monteiro, E. C. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105407 · Cited by 22 · see citing works
Lidington, D., Wan, H., Dinh, D. D., Ng, C., & Bolz, S.-S. (2021) · Stroke · doi:10.1161/strokeaha.121.036950 · Cited by 21 · see citing works
Duong, A., Reitz, C. J., Louth, E. L., Creighton, S. D., Rasouli, M., Zwaiman, A., Kroetsch, J. T., Bolz, S., Winters, B. D., Bailey, C. D. C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41469-7 · Cited by 21 · see citing works
Epicatechin-3-Gallate Signaling and Protection against Cardiac Ischemia/Reperfusion Injury
Qi, Y., Yang, C., Jiang, Z., Wang, Y., Zhu, F., Li, T., Wan, X., Xu, Y., Xie, Z., Li, D., et al. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.260117 · Cited by 21 · see citing works
Self-citationCircadian Rhythm of Lipid Metabolism in Health and Disease
Zhang, Z., Xin, H., & Li, M. (2020) · Small Methods · doi:10.1002/smtd.201900601 · Cited by 21 · see citing works
Potential Effect of the Circadian Clock on Erectile Dysfunction
Li, T., Bai, Y., Jiang, Y., Jiang, K., Tian, Y., Wang, Z., Ban, Y., Liang, X., Luo, G., & Sun, F. (2022) · Aging and Disease · doi:10.14336/ad.2021.0728 · Cited by 19 · see citing works
Wu, J. F., Fang, S., Lu, K., Kumar, G., Reho, J. J., Brozoski, D., Otanwa, A. J., Hu, C., Nair, A. R., Wackman, K. K., et al. (2022) · Function · doi:10.1093/function/zqac017 · Cited by 19 · see citing works
Chen, J., Chen, J., Zhu, T., Fu, Y., Cheong, I. H., Yi, K., Wang, H., & Li, X. (2022) · SLEEP · doi:10.1093/sleep/zsac257 · Cited by 19 · see citing works
Huo, M., Cao, X., Zhang, H., Lau, C. W., Hong, H., Chen, F. M., Huang, Y., Chawla, A., & Tian, X. Y. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab336 · Cited by 19 · see citing works
Su, Y., Foppen, E., Fliers, E., & Kalsbeek, A. (2016) · Endocrinology · doi:10.1210/en.2016-1083 · Cited by 18 · see citing works
Kim, H. K., Kim, H. J., Kim, J. H., Kim, T. H., & Lee, S. H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194018 · Cited by 19 · see citing works
Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis
Wei, L., & Shi, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.886534 · Cited by 18 · see citing works
Circadian and Diurnal Regulation of Cerebral Blood Flow
Webb, A. J. S., Klerman, E. B., & Mandeville, E. T. (2024) · Circulation Research · doi:10.1161/circresaha.123.323049 · Cited by 18 · see citing works
Circadian rhythm and atherosclerosis (Review)
Zhang, Z., Yu, B., Wang, X., Luo, C.-Y., Zhou, T., Zheng, X., & Ding, J. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9224 · Cited by 17 · see citing works
Time‐of‐day variation in vascular function
Rodrigo, G. C., & Denniff, M. (2016) · Experimental Physiology · doi:10.1113/ep085780 · Cited by 16 · see citing works
Time-restricted feeding reduces cardiovascular disease risk in obese mice
Pati, P., Miguel, C. D., Paul, J. R., Zhang, D., Colson, J. C., Allan, J. M., Edell, C., Rhoads, M. K., Dunaway, L. S., Biswal, S. N., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.160257 · Cited by 17 · see citing works
Cai, Q., Ji, S., Sun, Y., Yu, L., Wu, X., & Xie, Z. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.034 · Cited by 16 · see citing works
Self-citationNuclear Receptors and Clock Components in Cardiovascular Diseases
Pourcet, B., & Duez, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189721 · Cited by 16 · see citing works
Current perspective on circadian function of the kidney
Benjamin, J. I., & Pollock, D. M. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00247.2023 · Cited by 18 · see citing works
Circadian Biology and the Neurovascular Unit
Li, W., Tiedt, S., Lawrence, J. H., Harrington, M. E., Musiek, E. S., & Lo, E. H. (2024) · Circulation Research · doi:10.1161/circresaha.124.323514 · Cited by 16 · see citing works
Review: Circadian clocks and rhythms in the vascular tree
Han, Q., Bagi, Z. A., & Rudic, R. D. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.04.010 · Cited by 16 · see citing works
Circadian rhythms in thrombosis and atherothrombotic events
Peñaloza-Martínez, E., Moreno, G., Aroca-Crevillén, A., Nieto, S. H., Vicent, L., Rosillo, N., Hidalgo, A., & Bueno, H. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2702051 · Cited by 16 · see citing works
Engeland, W. C., Massman, L., Miller, L. A., Leng, S., Pignatti, E., Pantano, L., Carlone, D. L., Kofuji, P., & Breault, D. T. (2019) · Endocrinology · doi:10.1210/en.2019-00357 · Cited by 16 · see citing works
Thakur, A., & Kishore, R. (2025) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2025.100131 · Cited by 15 · see citing works
Kroetsch, J. T., Lidington, D., Alibhai, F. J., Reitz, C. J., Zhang, H., Dinh, D. D., Hanchard, J., Khatua, T. N., Heximer, S. P., Martino, T. A., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac174 · Cited by 15 · see citing works
Immunohistochemistry of the circadian clock in mouse and human vascular tissues
Anea, C. B., Merloiu, A. M., Fulton, D. J., Patel, V. S., & Rudic, R. D. (2018) · Vessel Plus · doi:10.20517/2574-1209.2018.46 · Cited by 15 · see citing works
Wu, G., Gu, W., Cheng, H., Guo, H., Li, D., & Xie, Z. (2022) · Foods · doi:10.3390/foods11192939 · Cited by 14 · see citing works
Self-citationCircadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension
Costello, H. M., Sharma, R. K., McKee, A. R., & Gumz, M. L. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.06.416 · Cited by 15 · see citing works
Circadian clocks regulate cardiac arrhythmia susceptibility, repolarization, and ion channels
Delisle, B. P., Stumpf, J. L., Wayland, J. L., Johnson, S. R., Ono, M., Hall, D., Burgess, D. E., & Schroder, E. A. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.09.015 · Cited by 14 · see citing works
Self-citationCircadian variations of vasoconstriction and blood pressure in physiology and diabetes
Hou, T., Guo, Z., & Gong, M. C. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.02.001 · Cited by 14 · see citing works
Self-citationHou, T., Chacon, A. N., Su, W., Katsumata, Y., Guo, Z., & Gong, M. C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.969345 · Cited by 13 · see citing works
Self-citationDevelopment of circadian neurovascular function and its implications
Mitchell, J. W., & Gillette, M. U. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1196606 · Cited by 12 · see citing works
Altamirano, F. G., Castro-Pascual, I. C., Ferramola, M. L., Tula, M. L., Delgado, S. M., Anzulovich, A. C., & Lacoste, M. G. (2021) · Biogerontology · doi:10.1007/s10522-021-09938-7 · Cited by 13 · see citing works
Crislip, G. R., Costello, H. M., Juffre, A., Cheng, K., Lynch, I. J., Johnston, J. G., Drucker, C. B., Bratanatawira, P., Agarwal, A., Mendez, V. M., et al. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00126.2023 · Cited by 13 · see citing works
Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral Forebrain
Mieda, M., Hasegawa, E., Kessaris, N., & Sakurai, T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00055 · Cited by 13 · see citing works
- Authors
- Xie, Z., Su, W., Liu, S., Zhao, G., Esser, K., Schroder, E. A., Lefta, M., Stauss, H. M., Guo, Z., & Gong, M. C.
- Affiliations
- Anhui Agricultural University (CN)
- University of Kentucky (US)
- University of Iowa (US)
- Corresponding author
- Xie, Zhongwen
- Su, Wen
- Guo, Zhenheng
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2014-12-08
- Volume
- 125
- Issue
- 1
- Pages
- 324-336
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4382248
- OpenAlex
- W2135667255
- Cited by
- 189
- References
- 54
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 19 · 2023: 13 · 2022: 20 · 2021: 23 · 2020: 24 · 2019: 17 · 2018: 19 · 2017: 7 · 2016: 13 · 2015: 7
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- Funders
- University of Kentucky (P20 GM103527, GM103527)
- National Institutes of Health (GM103527)
- National Heart, Lung, and Blood Institute (R01HL106843, HL088389, HL106843, R01HL088389)
- National Institute of General Medical Sciences (GM-103527, P20GM103527)
- National Institute of Environmental Health Sciences (RC1ES018636)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR066082)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- Bmal1, clock genes, circadian blood pressure rhythm, smooth muscle, ROCK2, vasoconstriction, myosin phosphorylation, mesenteric arteries, suprachiasmatic nucleus
- MeSH terms
- Animals, Blood Pressure, Circadian Rhythm, Enzyme Induction, Male, Mesenteric Arteries, Muscle Contraction, Muscle, Smooth, Vascular, Promoter Regions, Genetic, Protein Binding, Protein Processing, Post-Translational, Vasoconstriction, Mice, Knockout, Myosin Light Chains, Muscle Development, rho-Associated Kinases, ARNTL Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review