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Cited by 41Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryOphthalmology and Eye Disorders

Depressive symptoms in patients with subclinical hypothyroidism – the effect of treatment with levothyroxine: a double-blind randomized clinical trial

Najafi, Laily, Malek, Mojtaba, Hadian, Ali, Ebrahim Valojerdi, Ameneh, Khamseh, Mohammad E., Aghili, Rokhsareh·2015·Endocrine Research
DOI 10.3109/07435800.2014.896924
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Abstract

Despite the increasing evidence for relationships between thyroid dysfunction and neuropsychiatric alterations, the effect of treatment of thyroid disease on various clinical psychiatric outcomes is controversial. The purpose of this study was to investigate the effect of levothyroxine treatment on depressive symptoms in subjects with subclinical hypothyroidism. A randomized double-blind placebo-controlled clinical trial was performed. Sixty subjects (51 females and 9 males) with subclinical hypothyroidism were enrolled. Beck Depression Inventory was completed for all participants at the beginning of the study and 12 weeks after enrollment. The intervention and control groups received levothyroxine and placebo, respectively, for 12 weeks. There were no statistical differences in the total depression score and its subscales between the two groups at the beginning of the study. The Beck Depression Inventory score decreased from 16.79 ± 13.25 to 12.37 ± 10.01 (p value = 0.04) in the intervention group. The change in score was not significant for the control group (13.77 ± 11.71 to 11.86 ± 10.71; p value= 0.16). The affective subscale of Beck Depression Inventory did not change after 12 weeks of treatment with levothyroxine, while somatic subscale remarkably improved in the intervention group (p value = 0.02). This study showed the efficacy of treatment of subclinical hypothyroidism in people with levothyroxine in relation to depressive symptoms.

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Crossref · 10.3109/07435800.2014.896924

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  • A randomised, placebo-controlled trial in 60 patients with subclinical hypothyroidism demonstrated a significant improvement in Beck Depression Inventory scores in those randomised to LT4 therapy, while improvement was not observed in the placebo group.

    “a randomised, placebo-controlled trial in 60 patients with subclinical hypothyroidism did demonstrate a significant improvement in Beck Depression Inventory (BDI) scores in those randomised to LT4 therapy, while improvement was not observed in the placebo group”

    From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [79]

  • In that trial, the effect in the LT4 group was driven strongly by improvements in the somatic subscale of the BDI, with no significant improvement in the affect scale.

    “The effect in the LT4 group was driven strongly by improvements in the somatic subscale of the BDI, with no significant improvement in the affect scale”

    From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [79]

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Authors
Najafi, L., Malek, M., Hadian, A., Ebrahim Valojerdi, A., Khamseh, M. E., & Aghili, R.
Affiliations
Iran University of Medical Sciences (IR)
Corresponding author
Khamseh, Mohammad E.
ORCID
Venue
Endocrine Research
Publisher
Informa UK Limited
Published
2015-03-16
Volume
40
Issue
3
Pages
121-126
ISSN
  • 0743-5800 (ISSN-L)
  • 1532-4206
DOI
10.3109/07435800.2014.896924
OpenAlex
W2078012661
Cited by
41
References
75
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 1
FWCI
3.77
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Tehran
  • Tehran University of Medical Sciences and Health Services
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords
subclinical hypothyroidism, depressive symptoms, levothyroxine, thyroid hormone replacement, somatic symptoms of depression, Beck Depression Inventory
MeSH terms
Adult, Depression, Double-Blind Method, Female, Humans, Hypothyroidism, Male, Middle Aged, Psychiatric Status Rating Scales, Severity of Illness Index, Thyroxine, Treatment Outcome, Young Adult

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