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Cited by 56Thyroid Disorders and TreatmentsBlood Coagulation and Thrombosis MechanismsBlood properties and coagulation

Impaired release of tissue plasminogen activator from the endothelium in Graves' disease — indicator of endothelial dysfunction and reduced fibrinolytic capacity

Li, Chen, Tan, Wang, Liang, Sun·1998·European Journal of Clinical Investigation
DOI 10.1046/j.1365-2362.1998.00381.x
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Abstract

Background: Patients with hyperthyroidism have increased plasma levels of von Willebrand factor (vWF). Changes in tissue plasminogen activator (t‐PA) and plasminogen activator inhibitor (PAI‐1), another two endothelium‐derived proteins and modulators of blood fibrinolytic activity, have not been reported in hyperthyroidism. Methods: The release of t‐PA by vascular endothelial cells after venous occlusion, basal blood concentrations of t‐PA, PAI‐1 and vWF were studied in 33 patients with hyperthyroidism, with most of them followed up 30 days after iodine radiotherapy. Results: Compared with control subjects, both the basal t‐PA levels in plasma and the increase in t‐PA levels with venous occlusion were significantly decreased in patients (P < 0.001), whereas plasma PAI‐1 and vWF levels were increased greatly (P < 0.001). At follow‐up, patients with normal plasma free thyroxine (T 4) and total tri‐iodothyronine (T 3) showed similar plasma levels of t‐PA, PAI‐1, vWF and release of t‐PA from endothelial cells as the control subjects (P > 0.05). In those with persistent elevated T 4 or T 3 levels, however, the basal plasma t‐PA level and the released t‐PA from endothelial cells during venous occlusion were significantly lower than in the control subjects (P < 0.001 and P < 0.005), and blood concentrations of PAI‐1 and vWF did not return to the normal range (P < 0.001 and P < 0.001). In all patients, serum thyroid hormone concentrations were inversely correlated with basal plasma t‐PA (T 4: r = –0.549, P < 0.001; T 3: r = –0.463, P < 0.001) and released t‐PA by endothelial cells (T 4: r = –0.505, P < 0.001; T 3: r = –0.450, P < 0.001) but strongly correlated with plasma PAI‐1 (T 4: r = 0.613, P < 0.001; T 3: r = 0.577, P < 0.001) and vWF (T 4: r = 0.457, P < 0.001; T 3: r = 0.564, P < 0.001). Conclusion: Hyperthyroid patients may experience vascular endothelial dysfunction and reduced fibrinolytic activity in blood.

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Crossref · 10.1046/j.1365-2362.1998.00381.x

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  • Excess thyroid hormone activity results in a procoagulant state, with increased VWF, FVIII, fibrinogen, and D-dimer in subclinical hyperthyroidism and elevations in fibrinogen, fibronectin, VWF, thrombomodulin, and PAI-1, with decreased t-PA in overt endogenous hyperthyroidism.

    “Excess thyroid hormone activity results in a procoagulant state, with increased VWF, FVIII, fibrinogen, and D-dimer in subclinical hyperthyroidism and elevations in fibrinogen, fibronectin, VWF, thrombomodulin, and PAI-1, with decreased t-PA in overt, endogenous hyperthyroidism”

    From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [113]

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Authors
Li, Chen, Tan, Wang, Liang, & Sun
Affiliations
Zunyi Medical University (CN)
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
1998-12
Volume
28
Issue
12
Pages
1050-1054
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
DOI
10.1046/j.1365-2362.1998.00381.x
OpenAlex
W2026218365
Cited by
56
References
26
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2018: 4 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 4
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1120 d)
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chinese Academy of Sciences
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
Keywords
Graves' disease, hyperthyroidism, tissue plasminogen activator, plasminogen activator inhibitor-1, von Willebrand factor, endothelial dysfunction, fibrinolysis, venous occlusion, thyroid hormone levels, thyroid autoimmunity, endothelial activation markers, thyroid peroxidase, thyroglobulin
MeSH terms
Adult, Endothelium, Vascular, Female, Graves Disease, Humans, Male, Tissue Plasminogen Activator, von Willebrand Factor, Plasminogen Activator Inhibitor 1

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