The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Non-lipid-related effects of statins
Open accessAbstract
The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have generally been attributed to their hypocholesterolaemic properties. However, as mevalonate and other intermediates of cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important cell functions, effects other than cholesterol reduction may explain the pharmacological properties of statins. In the present review, we discuss the current knowledge on the nonlipid-related effects of statins, with a special emphasis on their potential benefits in different diseases, such as atherosclerosis and cancer. The mechanism(s) responsible for their favourable properties are also reviewed.
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Cites
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New insights into the pharmacodynamic and pharmacokinetic properties of statins
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Cited by
Mammalian Krüppel-Like Factors in Health and Diseases
McConnell, B. B., & Yang, V. W. (2010) · Physiological Reviews · doi:10.1152/physrev.00058.2009 · Cited by 1,018
Statins: mechanism of action and effects
Stancu, C., & Sima, A. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00172.x · Cited by 911
Mevalonate pathway: A review of clinical and therapeutical implications
Buhaescu, I., & Izzedine, H. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.03.016 · Cited by 620
Role of Krüppel-Like Transcription Factors in Endothelial Biology
Atkins, G. B., & Jain, M. K. (2007) · Circulation Research · doi:10.1161/01.res.0000267856.00713.0a · Cited by 419
Biological Properties of Olive Oil Phytochemicals
Visioli, F., & Galli, C. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690290825529 · Cited by 369
Metadata
- Authors
- Bellosta, S., Fed, N., Bernini, F., Paoletti, R., & Corsini, A.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 32
- Issue
- 3
- Pages
- 164-176
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2150565253
- Cited by
- 333
- References
- 11
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bellosta, S., Fed, N., Bernini, F., Paoletti, R., & Corsini, A. (2000). Non-lipid-related effects of statins. Annals of Medicine. https://doi.org/10.3109/07853890008998823
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
