The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Role of serotonin in memory impairment.
Abstract
As a result of its presence in various structures of the central nervous system serotonin (5-HT) plays a role in a great variety of behaviours such as food intake, activity rythms, sexual behaviour and emotional states. Despite this lack of functional specialization, the serotonergic system plays a significant role in learning and memory, in particular by interacting with the cholinergic, glutamatergic, dopaminergic or GABAergic systems. Its action is mediated via specific receptors located in crucial brain structures involved in these functions, primarily the septo-hippocampal complex and the nucleus basalis magnocellularis (NBM)-frontal cortex. Converging evidence suggests that the administration of 5-HT2A/2C or 5-HT4 receptor agonists or 5-HT1A or 5-HT3 and 5-HT1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand. In contrast, antagonists for 5-HT2A/2C and 5-HT4, or agonists for 5-HT1A or 5-HT3 and 5-HT1B generally have opposite effects. A better understanding of the role played by these and other serotonin receptor subtypes in learning and memory is likely to result from the recent availability of highly specific ligands, such as 5-HT1A, 5-HT1B, 5-HT2A receptor antagonists, and new molecular tools, such as gene knock-out mice, especially inducible mice in which a specific genetic alteration can be restricted both temporally and anatomically.
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“The action of the monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) in the hippocampus is known to facilitate the process of hippocampal learning and memory (Riedel et al., 1999; Buhot et al., 2000).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Buhot et al., 2000
Citations
Cites
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Self-citationSerotonin receptor 1A knockout: An animal model of anxiety-related disorder
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Sorted by citations
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942
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5-HT Receptor Regulation of Neurotransmitter Release
Fink, K., & Göthert, M. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.07103 · Cited by 389
Metadata
- Authors
- Buhot, M.-C., Martin, S., & Segu, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Buhot, Marie-Christine
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 32
- Issue
- 3
- Pages
- 210-221
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W1973475326
- Cited by
- 419
- References
- 123
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 19 · 2020: 15 · 2019: 14 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 8 · 2014: 19 · 2013: 18 · 2012: 15
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, serotonin receptors, memory impairment, learning, 5-HT2A/2C receptors, 5-HT4 receptor, 5-HT1A receptor, 5-HT3 receptor, 5-HT1B receptor, serotonergic system, nucleus basalis magnocellularis, cholinergic system, glutamatergic system, dopaminergic system, GABAergic system, inducible knockout mice
- MeSH terms
- Aging, Alzheimer Disease, Animals, Brain, Cognition, Humans, Limbic System, Memory Disorders, Receptors, Serotonin, Serotonin, Mice, Knockout, Mice
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