Cited by 420Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Role of serotonin in memory impairment.

Buhot, Marie-Christine, Martin, Stéphanie, Segu, Louis·2000·Annals of Medicine

DOI 10.3109/07853890008998828

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Abstract

As a result of its presence in various structures of the central nervous system serotonin (5-HT) plays a role in a great variety of behaviours such as food intake, activity rythms, sexual behaviour and emotional states. Despite this lack of functional specialization, the serotonergic system plays a significant role in learning and memory, in particular by interacting with the cholinergic, glutamatergic, dopaminergic or GABAergic systems. Its action is mediated via specific receptors located in crucial brain structures involved in these functions, primarily the septo-hippocampal complex and the nucleus basalis magnocellularis (NBM)-frontal cortex. Converging evidence suggests that the administration of 5-HT2A/2C or 5-HT4 receptor agonists or 5-HT1A or 5-HT3 and 5-HT1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand. In contrast, antagonists for 5-HT2A/2C and 5-HT4, or agonists for 5-HT1A or 5-HT3 and 5-HT1B generally have opposite effects. A better understanding of the role played by these and other serotonin receptor subtypes in learning and memory is likely to result from the recent availability of highly specific ligands, such as 5-HT1A, 5-HT1B, 5-HT2A receptor antagonists, and new molecular tools, such as gene knock-out mice, especially inducible mice in which a specific genetic alteration can be restricted both temporally and anatomically.

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Authors: Buhot, M.-C., Martin, S., & Segu, L.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Buhot, Marie-Christine
Venue: Annals of Medicine
Publisher: Informa UK Limited
Published: 2000-01
Volume: 32
Issue: 3
Pages: 210-221
ISSN: 0785-3890 (ISSN-L)
1365-2060
DOI: 10.3109/07853890008998828
OpenAlex: W1973475326
Cited by: 419
References: 123
Citations by year: 2026: 4 · 2025: 8 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 19 · 2020: 15 · 2019: 14 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 8 · 2014: 19 · 2013: 18 · 2012: 15
FWCI: 6.29
Type: journal article
Language: en
Open access: closed
Locations: Annals of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: serotonin, serotonin receptors, memory impairment, learning, 5-HT2A/2C receptors, 5-HT4 receptor, 5-HT1A receptor, 5-HT3 receptor, 5-HT1B receptor, serotonergic system, nucleus basalis magnocellularis, cholinergic system, glutamatergic system, dopaminergic system, GABAergic system, inducible knockout mice
MeSH terms: Aging, Alzheimer Disease, Animals, Brain, Cognition, Humans, Limbic System, Memory Disorders, Receptors, Serotonin, Serotonin, Mice, Knockout, Mice

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