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The Health Utilities Index (HUI®) system for assessing health-related quality of life in clinical studies
Open accessAbstract
This paper reviews the Health Utilities Index (HUI) systems as means to describe health status and obtain utility scores reflecting health-related quality of life (HRQoL). The HUI Mark 2 (HUI2) and Mark 3 (HUI3) classification and scoring systems are described. The methods used to estimate multiattribute utility functions for HUI2 and HUI3 are reviewed. The use of HUI in clinical studies for a wide variety of conditions in a large number of countries is illustrated. HUI provides a comprehensive description of the health status of subjects in clinical studies. HUI has been shown to be a reliable, responsive and valid measure in a wide variety of clinical studies. Utility scores provide an overall assessment of the HRQoL of patients. Utility scores are also useful in cost-utility analyses and related studies. General population norm data are available. The widespread use of HUI facilitates the interpretation of results and permits comparisons. HUI is a useful tool for assessing health status and HRQoL in clinical studies.
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“The Health Utilities Index (HUI) provides indicators of multiple attributes of health status for use in economic evaluations of healthcare programmes. It has well-established validity and reliability in many clinical contexts (test–retest reliability of 0.767 intraclass correlation coefficient).77 78”
From Coached, Coordinated, Enhanced Neonatal Transition (CCENT): Protocol for a multicentre pragmatic randomised controlled trial of transition-to-home support for parents of high-risk infants (2021) · cites this paper as [77]
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The association between neurodevelopmental disability and economic outcomes during mid‐childhood
Petrou, S., Johnson, S. J., Dieter Wolke, C., & Marlow, N. (2012) · Child Care Health and Development · doi:10.1111/j.1365-2214.2012.01368.x · Cited by 45
“…both clinical and general population health studies, improvements in a number of definitions, and an increased orthogonality of its attributes for structural independence (Furlong et al. 2001; Horsman et al. 2003), our primarily analyses were based on the HUI3 health status classification system.”
MethodYour Money or Your Life: A Prescriptive Model for Health, Safety, and Consumption Decisions
Smith, J. E., & Keeney, R. L. (2005) · Management Science · doi:10.1287/mnsc.1050.0402 · Cited by 45
“1982, Furlong et al. 2001) have developed a health utilities index that is used in many H-QALY studies. However, we would need to verify the use of such utilities as a multiplier on consumption utilities as they are used in this framework. The other utility parameters can be assessed using standard utility assessment…”
Diabetes and its impact on health-related quality of life: a life table analysis
Sikdar, K. C., Wang, P. P., MacDonald, D., & Gadag, V. G. (2010) · Quality of Life Research · doi:10.1007/s11136-010-9641-5 · Cited by 43
Roposch, A., Liu, L. Q., Offiah, A. C., & Wedge, J. H. (2011) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.j.01623 · Cited by 44
Kulkarni, A. V., Shams, I., Cochrane, D. D., & McNeely, P. D. (2010) · Journal of Neurosurgery Pediatrics · doi:10.3171/2010.3.peds09358 · Cited by 44
Taylor, R. W., Brown, D. A., Dawson, A. M., Haszard, J. J., Cox, A., Rose, E. A., Taylor, B. J., Meredith-Jones, K. A., Treacy, L., Ross, J., et al. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-271 · Cited by 44
“As utilities have not been determined for PedsQL, quality of life will also be measured using the Health Utilities Index [ 83 ,84].”
MethodEconomic evaluation of treatments for cancer in childhood
Barr, R. D., Feeny, D. H., & Furlong, W. J. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.01.033 · Cited by 44
“The three major systems are the Quality of Well Being (QWB) Scale [18], the EuroQol EQ-5D [19], and the Health Utilities Index (HUI) [20–23].”
BackgroundMethodInfluentialSelf-citationZwolan, T. A., Kallogjeri, D., Firszt, J. B., & Buchman, C. A. (2020) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2020.2286 · Cited by 44
“Best-aided condition 38 (16-60) 76 (40-90) 74 (34-94)”
BackgroundInfluentialFluchel, M. N., Horsman, J., Furlong, W. J., Castillo, L. A., Alfonz, Y., & Barr, R. D. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.21299 · Cited by 44
“Where this has been studied elsewhere, the HRQL of survivors of brain tumors has been markedly less than that of ALL [10].”
ResultSelf-citationDo We Know Where We Stand? Neighborhood Relative Income, Subjective Social Status, and Health
Roy, A. L., Godfrey, E. B., & Rarick, J. R. D. (2016) · American Journal of Community Psychology · doi:10.1002/ajcp.12049 · Cited by 43
Spirituality of Parents of Children in Palliative Care
Knapp, C. A., Madden, V. L., Wang, H., Curtis, C. M., Sloyer, P. J., & Shenkman, E. A. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.0387 · Cited by 43
Cochlear Implantation in Patients With Advanced Ménière’s Disease
Mick, P. T., Amoodi, H. A., Arnoldner, C., Shipp, D. B., Friesen, L. M., Lin, V., Nedzelski, J. M., & Chen, J. (2013) · Otology & Neurotology · doi:10.1097/mao.0000000000000202 · Cited by 43
“The Health Utilities Index has replaced the SF-36 at our institution because it includes items specifically related to auditory-vestibular deficits and it can be converted into Quality-Adjusted Life-Year scores for health-economic assessment (28).”
MethodKaplan, R. M., Tally, S., Hays, R. D., Feeny, D., Ganiats, T. G., Palta, M., & Fryback, D. G. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.04.010 · Cited by 55
Self-citationBryan, S., Davis, J. C., Broesch, J., Doyle‐Waters, M. M., Lewis, S. J., McGrail, K., McGregor, M. J., Murphy, J., & Sawatzky, R. (2014) · Healthcare policy · doi:10.12927/hcpol.2015.24035 · Cited by 41
“…et al. 1993, 1996; Bouchet et al. 2000; Brazier et al. 1999; Butterworth and Crosier 2004; Coons et al. 2000; Doward et al. 2004; Ford et al. 2000; Furlong et al. 2001; Gandek et al. 2004; Hawthorne and Richardson 2001; Hays et al. 2009; Haywood et al. 2005; Horsman et al. 2003; Kopec and…”
BackgroundMethodPreference‐Based Quality of Life Measures in People with Visual Impairment
Kymes, S. M., & Lee, B. S. (2007) · Optometry and Vision Science · doi:10.1097/opx.0b013e3181337638 · Cited by 42
Davison, S. N., Jhangri, G. S., & Feeny, D. H. (2008) · Value in Health · doi:10.1111/j.1524-4733.2008.00433.x · Cited by 42
Self-citationMoga, D. C., Carnahan, R. M., Lund, B. C., Pendergast, J., Wallace, R. B., Torner, J. C., Li, Y., & Chrischilles, E. A. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.03.008 · Cited by 42
Unilateral Multi-Channel Cochlear Implantation Results in Significant Improvement in Quality of Life
Chung, J., Chueng, K., Shipp, D. B., Friesen, L. M., Chen, J. M., Nedzelski, J. M., & Lin, V. (2012) · Otology & Neurotology · doi:10.1097/mao.0b013e3182536dc2 · Cited by 42
“Since that time, there have been multiple HRQoL assessments that have been developed to evaluate post-CI outcomes such as the Health Utility Index, Mark II (HUI-II) (38), and the disease-specific HRQOL questionnaire for adult CI users: the Nijmegen Cochlear Implant Questionnaire (14).”
BackgroundSladen, D. P., Peterson, A., Schmitt, M., Olund, A. P., Teece, K. H., Dowling, B. P., DeJong, M. D., Breneman, A. I., Beatty, C. W., Carlson, M. L., et al. (2017) · Cochlear Implants International · doi:10.1080/14670100.2017.1293203 · Cited by 42
“Similar studies have also been done using generic HRQoL measures (Chung et al., 2012; Krabbe et al., 2000) such as the Health Utilities Index (HUI; Furlong et al., 2001) and the Medical Outcome Study Short Form (SF-36; Ware and Sherbourne, 1992).”
BackgroundChallenges to the measurement of health‐related quality of life in children receiving cancer therapy
Nathan, P. C., Furlong, W. J., & Barr, R. D. (2004) · Pediatric Blood & Cancer · doi:10.1002/pbc.20096 · Cited by 42
“The BASES instrument has been demonstrated to be sensitive to changes in HRQL in bone marrow transplant recipients over consecutive 1 week periods [43]; the HUI2 and HUI3 have been shown to be similarly sensitive in a small study of children receiving ALL maintenance therapy [19,44].”
MethodSelf-citationValuation of Child Health‐Related Quality of Life in the United States
Craig, B. M., Greiner, W., Brown, D. S., & Reeve, B. B. (2015) · Health Economics · doi:10.1002/hec.3184 · Cited by 44
“studies, such as the Health Utilities Index Mark II, apply identical values to generic health instrument regardless of patient age, which may inform economic evaluations (Furlong et al., 2001).”
InfluentialRadiology Cost and Outcomes Studies: Standard Practice and Emerging Methods
Hollingworth, W. (2005) · American Journal of Roentgenology · doi:10.2214/ajr.04.1780 · Cited by 41
“Alternatively, in an increasing number of studies, Q is estimated indirectly via a quality of life questionnaire such as the EQ-5D [33] or the Health Utilities Index [34].”
MethodEvaluating Primary Treatment for People with Advanced Glaucoma
King, A. J., Hudson, J., Azuara‐Blanco, A., Burr, J. M., Kernohan, A., Homer, T. M., Shabaninejad, H., Sparrow, J. M., Garway‐Heath, D. F., Barton, K., et al. (2024) · Ophthalmology · doi:10.1016/j.ophtha.2024.01.007 · Cited by 40
The Implications of Using US-Specific EQ-5D Preference Weights for Cost-Effectiveness Evaluation
Noyes, K., Dick, A. W., & Holloway, R. G. (2007) · Medical Decision Making · doi:10.1177/0272989x07301822 · Cited by 40
Quality of life among children with spina bifida in Uganda
Sims-Williams, H. J., Sims-Williams, H. P., Kabachelor, E. M., & Warf, B. C. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2016-312307 · Cited by 40
Comparing population health in the United States and Canada
Feeny, D. H., Kaplan, M. S., Huguet, N., & McFarland, B. H. (2010) · Population Health Metrics · doi:10.1186/1478-7954-8-8 · Cited by 40
“HUI3 is based on eight dimensions, or attributes, of health status: vision, hearing, speech, ambulation dexterity, emotion, cognition, and pain and discomfort [21-24].”
BackgroundSelf-citationWittenberg, E., Joshi, M., Thomas, K. A., & McCloskey, L. A. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-67 · Cited by 40
“, SF-12, SF-6D [10-12]), the Health Utilities Index (HUI [13], the EuroQol 5D (EQ-5D [14]), and the Quality of Well-Being Scale (QWB [15]).”
Kopec, J. A., Sayre, E. C., Davis, A. M., Badley, E. M., Abrahamowicz, M., Sherlock, L., Williams, J. I., Anis, A. H., & Esdaile, J. M. (2006) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-4-33 · Cited by 40
Some methodological issues with the analysis of preference-based EQ-5D index score
Li, L., & Fu, A. Z. (2009) · Health Services and Outcomes Research Methodology · doi:10.1007/s10742-009-0053-3 · Cited by 39
Using Happiness to Value Health
Dolan, P. (2011) · Monographs · Cited by 39
Health-Related Quality of Life and Utility in Patients With Age-Related Macular Degeneration
Sahel, J. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.7.945 · Cited by 39
“00 (perfect health).(39-43) Negative HRQoL scores, corresponding to a state of “worse than dead,” are also possible.”
BackgroundOdibo, A. O., Coassolo, K. M., Stamilio, D. M., Ural, S., & Macones, G. A. (2005) · Prenatal Diagnosis · doi:10.1002/pd.1322 · Cited by 38
Kruithof, N., Haagsma, J. A., Karabatzakis, M., Cnossen, M. C., de Munter, L., van de Ree, C. L. P., de Jongh, M. A. C., & Polinder, S. (2018) · Injury · doi:10.1016/j.injury.2018.08.016 · Cited by 46
Sereda, M., Xia, J., Scutt, P., Hilton, M. P., Refaie, A. E., & Hoare, D. J. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013514.pub2 · Cited by 37
Talbird, S. E., Taylor, T. N., Knoll, S., Frostad, C. R., & Martí, S. G. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.06.016 · Cited by 38
Richter, H. E., Burgio, K. L., Goode, P. S., Borello‐France, D., Bradley, C. S., Brubaker, L. T., Handa, V. L., Fine, P. M., Visco, A. G., Zyczynski, H. M., et al. (2007) · Clinical Trials · doi:10.1177/1740774506075237 · Cited by 38
“The Health Utility Item (HUI) [20], a single validated self-assessment question, is used to measure how a patient feels about her overall health status.”
MethodSlaughter, S. E., Estabrooks, C. A., Jones, C. A., & Wagg, A. (2011) · BMC Geriatrics · doi:10.1186/1471-2318-11-84 · Cited by 37
“The Health Utilities Index Mark 2 and 3 (HUI2/3) is a generic health-related quality of life questionnaire based on two generic multi-attribute preference-based systems: the HUI2 and the HUI3 [69].”
BackgroundInfluentialWolstenholme, J. L., Bargo, D., Wang, K., Harnden, A., Räisänen, U., & Abel, L. (2018) · Quality of Life Research · doi:10.1007/s11136-018-1831-6 · Cited by 38
Socias, M. E., Ahamad, K., Foll, B. L., Lim, R., Bruneau, J., Fischer, B., Wild, T. C., Wood, E., & Jutras‐Aswad, D. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.04.001 · Cited by 37
“Exploratory outcome measures Exploratory outcome measures will include: (1) cost-effectiveness and quality of life, assessed by the EuroQoL-5D (EQ-5D) [32, 33] Health Utilities Index III (HUI3) [34] instruments, as well as information on health service utilization; (2) pain, assessed by the Brief Pain Inventory- Short…”
MethodWegner, I., Hall, D. A., Smit, A. L., McFerran, D. J., & Stegeman, I. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013093.pub2 · Cited by 36
Cost-effectiveness of cataract surgery in Japan
Eye Care Comparative Effectiveness Research Team (ECCERT) (2011) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-011-0041-3 · Cited by 37
Sawka, A. M., Thabane, L., Παπαϊωάννου, Α., Gafni, A., Ioannidis, G., Papadimitropoulos, E., Hopman, W. M., Cranney, A., Hanley, D. A., Pickard, L. E., et al. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1949-6 · Cited by 37
“00 (perfect health), where a score of zero represents a state equivalent to death [14, 15, 16].”
BackgroundKwon, J., Smith, S. C., Raghunandan, R., Howell, M., Huynh, E. K., Kim, S. W., Bentley, T., Roberts, N. W., Lancsar, E., Howard, K., et al. (2023) · Applied Health Economics and Health Policy · doi:10.1007/s40258-023-00806-8 · Cited by 40
“Other instruments also had high proportions of ‘+’: AQoL-6D, 100% from two; EQ-5D-Y-3L, 100% from one; HUI2, 80% from five; and HUI3, 100% from three.”
BackgroundMethodInfluentialLima, V. D., & Kopec, J. A. (2004) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.05.024 · Cited by 35
Patient Satisfaction After Midurethral Sling Surgery for Stress Urinary Incontinence
Wai, C. Y., Curto, T. M., Zyczynski, H. M., Stoddard, A. M., Burgio, K. L., Brubaker, L. T., Rickey, L., & Menefee, S. A. (2013) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31828ca49e · Cited by 36
“Self-assessment of overall health was determined using the Health Utilities Index measure of overall health, which yields scores ranging from 1 (excellent) to 5 (poor).(10) Pelvic organ prolapse was assessed with the Pelvic Organ Prolapse Quantification System.”
MethodHealth Status Measurements at Diagnosis As Predictors of Survival Among Adults With Brain Tumors
McCarter, H., Furlong, W. J., Whitton, A. C., Feeny, D. H., Depauw, S., Willan, A. R., & Barr, R. D. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.0137 · Cited by 35
Self-citationThoma, A., Sprague, S., Veltri, K. L., Duku, E., & Furlong, W. J. (2005) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-3-44 · Cited by 36
“The current study is the first to use the Health Utilities Index (HUI) as an outcome assessment [25-28].”
BackgroundMethodInfluentialSelf-citationDevelopment and implementation of a telehealth-enhanced intervention for pain and symptom management
Eaton, L. H., Gordon, D. B., Wyant, S., Theodore, B. R., Meins, A. R., Rue, T. C., Towle, C. B., Tauben, D. J., & Doorenbos, A. Z. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.05.005 · Cited by 35
“b,d HUI-3 [42–45] (quality of life) X”
BackgroundHealth‐related quality of life and functional impairment in acute vestibular disorders
Möhwald, K., Hadzhikolev, H., Bardins, S., Becker‐Bense, S., Brandt, T., Grill, E., Jahn, K., Dieterich, M., & Zwergal, A. (2020) · European Journal of Neurology · doi:10.1111/ene.14318 · Cited by 36
“The Health Utilities Index Mark 2,3 is more sensitive in this respect [43].”
BackgroundXu, F., Chen, G., Stevens, K. J., Zhou, H., Qi, S., Wang, Z., Hong, X., Chen, X., Yang, H., Wang, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089222 · Cited by 37
“Presently there are four popular preference-based generic instruments available for young people: the Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3) [14], the European Quality of Life 5 Dimension Youth version (EQ-5D-Y) [15,16], the Assessment of Quality of Life 6-Dimension (AQoL-6D) [17], and the Child Health…”
BackgroundPetrou, S., McCann, D., Law, C., Watkin, P. M., Worsfold, S., & Kennedy, C. (2007) · PEDIATRICS · doi:10.1542/peds.2007-0159 · Cited by 35
Cost-utility analysis of a dance intervention for adolescent girls with internalizing problems
Philipsson, A., Duberg, A., Möller, M., & Hagberg, L. (2013) · Cost Effectiveness and Resource Allocation · doi:10.1186/1478-7547-11-4 · Cited by 35
“QOL was measured with the Health Utility Index Mark 3 (HUI3) [27].”
BackgroundMethodInfluentialPotential human health benefits of antibiotics used in food animals: a case study of virginiamycin
Cox, L. A. (2004) · Environment International · doi:10.1016/j.envint.2004.10.012 · Cited by 35
de Climens, A. R., Tunceli, K., Arnould, B., Germain, N., Iglay, K., Norquist, J. M., & Brodovicz, K. G. (2015) · Current Medical Research and Opinion · doi:10.1185/03007995.2015.1020364 · Cited by 35
Rehm, J. T., & Frick, U. (2010) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.300 · Cited by 33
“health status instruments: the Health Utilities Index Mark III (HUI3; Feeny et al., 2002; Furlong et al., 2001),”
Quality of Life Measurements after Cochlear Implantation
Loeffler, C., Aschendorff, A., Bürger, T., Kröger, S., Laszig, R., & Arndt, S. (2010) · The Open Otorhinolaryngology Journal · doi:10.2174/1874428101004010047 · Cited by 34
“Their reliability and validity has been proven in a wide variety of clinical studies [18].”
BackgroundHarmonising summary measures of population health using global survey instruments
Berger, N., Robine, J., Ojima, T., Madans, J. H., & Oyen, H. J. V. (2016) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2015-206870 · Cited by 33
Poole, K. L., Lieshout, R. J. V., & Schmidt, L. A. (2017) · Journal of Social and Clinical Psychology · doi:10.1521/jscp.2017.36.4.316 · Cited by 33
Modeling health-related quality of life in people recovering from stroke
Mayo, N. E., Scott, S. C., Bayley, M. T., Cheung, A. M., Garland, S. J., Jutai, J. W., & Wood-Dauphinée, S. (2013) · Quality of Life Research · doi:10.1007/s11136-013-0605-4 · Cited by 33
“Variables and indicators of symptoms, functioning, and health perception were taken from subscales or questions in the Stroke Impact Scale (SIS) [42], RAND-36 [43], Health Utilities Inventory (HUI) [44], Brief Mini-Mental State Examination (MMSE) that is a measure of cognitive impairment adapted for scoring over the t…”
MethodUsing Preference-Based Measures to Assess Quality of Life in Stuttering
Bramlett, R. E., Bothe, A. K., & Franic, D. M. (2006) · Journal of Speech Language and Hearing Research · doi:10.1044/1092-4388(2006/030 · Cited by 33
Is the health utilities index responsive in total hip arthroplasty patients?
Blanchard, C. M., Feeny, D. F., Mahon, J. L., Bourne, R. B., Rorabeck, C. H., Stitt, L., & Webster-Bogaert, S. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00203-8 · Cited by 33
“These scores provide a measure of attribute-specific morbidity [16–20].”
BackgroundMethodSelf-citationValidation of the Episodic Disability Framework with adults living with HIV
O’Brien, K. K., Hanna, S., Gardner, S. L., Bayoumi, A. M., Rueda, S., Hart, T. A., Cooper, C., Solomon, P. E., Rourke, S. B., Davis, A. M., et al. (2013) · Disability and Rehabilitation · doi:10.3109/09638288.2013.793408 · Cited by 29
“items, from which domain scores may be calculated for vision, hearing, speech, dexterity, pain, emotion, cognition, mobility, self-care and ambulation [22,35].”
BackgroundBhandari, M., Sprague, S., Ayeni, O. R., Hanson, B., & Moro, J. K. (2004) · Acta Orthopaedica Scandinavica · doi:10.1080/00016470410001708200 · Cited by 32
“A multiplicative multi-attribute utility function and single-attribute utility functions for HUI mark 3 have recently been published (Furlong et al. 2001).”
BackgroundMethodInfluentialCheng, S. S., Teuffel, O., Ethier, M. C., Diorio, C. J., Martino, J. G., Mayo, C., Regier, D. A., Wing, R., Alibhai, S. M. H., & Sung, L. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.213 · Cited by 32
“Abbreviations: FN¼ febrile neutropaenia; HRQL¼ health-related quality of life; HUI¼ health utilities index; IQR¼ interquartile range; VAS¼ visual analogue scale. aMissing for 10 parents. bNot all respondents answered each question. cOther – haemophagocytic lymphohistiocytosis. dFor parent respondents: N¼ 82 and 84 for…”
BackgroundInfluentialSelf-Perceptions of Physical Activity in Survivors of Acute Lymphoblastic Leukemia in Childhood
Wright, M. J., Galea, V., & Barr, R. D. (2003) · Pediatric Exercise Science · doi:10.1123/pes.15.2.191 · Cited by 32
Self-citationTorrance, G. W., Tugwell, P., Amorosi, S. L., Chartash, E., & Sengupta, N. (2004) · Lara D. Veeken · doi:10.1093/rheumatology/keh153 · Cited by 32
“The HUI3 classification system consists of eight attributes (vision, hearing, speech, ambulation, dexterity, emotion, cognition and pain) and five or six levels on each attribute, ranging from full function to severe impairment [ 12 , 13].”
BackgroundMethodSelf-citationThe Short Form 6 Dimensions (SF-6D): Development and Evolution
Mukuria, C., Rowen, D., Mulhern, B. J., McDool, E., Kharroubi, S. A., Bjørner, J. B., & Brazier, J. E. (2024) · Applied Health Economics and Health Policy · doi:10.1007/s40258-024-00919-8 · Cited by 35
“SF-6D SF-6D does not include impairments, such as vision, hearing and dexterity that are included in measures, such as the Health Utilities Index (HUI) [97] but instead focuses on the impact of these limitations on higher level dimensions.”
Furlong, W. J., Rae, C. S., Feeny, D. H., Ghotra, S., Breakey, V. R., Carter, T., Pai, N., Pullenayegum, E., Xie, F., & Barr, R. D. (2022) · Value in Health · doi:10.1016/j.jval.2022.07.015 · Cited by 35
Self-citationCommon generic measures of health related quality of life in injured patients
Shearer, D., & Morshed, S. (2010) · Injury · doi:10.1016/j.injury.2010.11.044 · Cited by 30
“The Health Utilities Index (HUI) is a preference-based questionnaire designed to generate a utility score from 0 to 1.(28,35) There are three versions that were developed chronologically: the Mark 1, Mark 2, and Mark 3.”
BackgroundMethodInfluentialQuinn, G. P., Huang, I., Murphy, D., Zidonik-Eddelton, K., & Krull, K. R. (2012) · Quality of Life Research · doi:10.1007/s11136-012-0120-z · Cited by 34
“Such generic instruments include the Medical Outcomes Study Short Form-36 (SF-36) [10], the Symptom Checklist-90 Revised [11], and Health Utility Index [12].”
MethodPotential methods and approaches to assess social impacts associated with food safety issues
Cope, S., Frewer, L. J., Renn, O., & Dreyer, M. (2009) · Food Control · doi:10.1016/j.foodcont.2009.05.008 · Cited by 31
Does cirrhosis affect quality of life in hepatitis C virus‐infected patients?
Hsu, P. C., Krajden, M., Yoshida, E. M., Anderson, F., TOMLINSON, G. A., & Krahn, M. D. (2009) · Liver International · doi:10.1111/j.1478-3231.2008.01865.x · Cited by 31
“The HUI2/HUI3 is a preference-scored indirect utility instrument that measures health status, reports on health-related QOL and produces utility scores (11, 12).”
BackgroundQuality of life in childhood hydrocephalus: a review
Kulkarni, A. V. (2010) · Child s Nervous System · doi:10.1007/s00381-010-1131-0 · Cited by 31
“Examples of generic measures include the Child Health Questionnaire, the Health Utilities Index, and the PedsQL [26, 55, 63].”
MethodTeuffel, O., Cheng, S. S., Ethier, M. C., Diorio, C. J., Martino, J. G., Mayo, C., Wing, R., Sung, L., & Alibhai, S. M. H. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1397-8 · Cited by 30
“The HUI is a family of multi-attribute health status classification systems which currently consists of two complementary systems, HUI2 and HUI3 [16].”
BackgroundPetrou, S., Dakin, H., Abangma, G., Benge, S., & Williamson, I. G. (2010) · Value in Health · doi:10.1111/j.1524-4733.2010.00711.x · Cited by 30
Kim, Y. J., Rogers, J. C., Raina, K. D., Callaway, C. W., Rittenberger, J. C., Leibold, M. L., & Holm, M. B. (2016) · Resuscitation · doi:10.1016/j.resuscitation.2016.05.020 · Cited by 30
Association of Systemic Comorbidities with Dry Eye Disease
Kawashima, M., Yamada, M., Shigeyasu, C., Suwaki, K., Uchino, M., Hiratsuka, Y., Yokoi, N., Tsubota, K., & for the DECS-J Study Group (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072040 · Cited by 30
Valuation of the EQ-5D-3L in Russia
Omelyanovskiy, V. V., Musina, N. Z., Ratushnyak, S., Bezdenezhnykh, T. P., Федяева, В. К., Roudijk, B., & Purba, F. D. (2021) · Quality of Life Research · doi:10.1007/s11136-021-02804-6 · Cited by 30
Health-Related Quality of Life from Adolescence to Adulthood Following Extremely Preterm Birth
Ni, Y., O’Reilly, H., Johnson, S. J., Marlow, N., & Dieter Wolke, C. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.04.005 · Cited by 30
Kawasaki, R., Akune, Y., Hiratsuka, Y., Fukuhara, S., & Yamada, M. (2014) · Ophthalmic Epidemiology · doi:10.3109/09286586.2014.988876 · Cited by 30
“TTO incorporates quality of life directly into the utility measure, which some researchers believe makes it a preferred method of measurement.(34,35) TTO utility was chosen because it is reproducible and reliable on a test-retest basis over a prolonged period of time.”
MethodTest–retest reliability of health utilities index scores: Evidence from hip fracture
Jones, C. A., Feeny, D. F., & Eng, K. K. (2005) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462305050518 · Cited by 30
“The attributes included in the HUI3 are vision, hearing, speech, ambulation, dexterity, emotion, cognition, and pain (10;12;16).”
BackgroundSelf-citationWhitehurst, D., Suryaprakash, N., Engel, L., Mittmann, N., Noonan, V., Dvorak, M., & Bryan, S. (2013) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-12-50 · Cited by 35
“Perceptions and opinions were solicited on the following questionnaires: 15D, Assessment of Quality of Life 8-dimension (AQoL-8D), EQ-5D-5L, Health Utilities Index (HUI), Quality of Well-Being Scale Self-Administered (QWB-SA), and the SF-36v2.”
MethodInfluentialEconomic impact of minimally invasive lumbar surgery
Hofstetter, C. P. (2015) · World Journal of Orthopedics · doi:10.5312/wjo.v6.i2.190 · Cited by 29
Longitudinal Evaluation of Transition Services (“LETS Study”): Protocol for outcome evaluation
Tsybina, I., Kingsnorth, S., Maxwell, J., Bayley, M. T., Lindsay, S., McKeever, P. D., Colantonio, A., Hamdani, Y., Healy, H., & Macarthur, C. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-51 · Cited by 29
“measures selected for the study have good psychometric properties [45,46,51-57].”
MethodNi, Y., Johnson, S. J., Marlow, N., & Dieter Wolke, C. (2021) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2021-322888 · Cited by 29
Effect of daily school and care disruptions during the COVID-19 pandemic on child behavior problems.
Gassman‐Pines, A., Ananat, E., Fitz-Henley, J., & Leer, J. (2022) · Developmental Psychology · doi:10.1037/dev0001373 · Cited by 28
“” ) was modi fi ed from a question from the Health Utilities Index (Furlong et al., 2001; Horsman et al., 2003) with a 4-week recall period.”
BackgroundEstimation of Tinnitus-Related Socioeconomic Costs in Germany
Tziridis, K., Friedrich, J., Brüeggemann, P., Mazurek, B., & Schulze, H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191610455 · Cited by 29
“Additionally, the patients were handed the standardized health utility questionnaire (HUI) for assessing the general physical health and quality of life [37].”
BackgroundHovén, E., Lannering, B., Gustafsson, G., & Boman, K. K. (2011) · Psycho-Oncology · doi:10.1002/pon.2067 · Cited by 29
“The HUI is applicable to a variety of populations, including childhood CNS tumor survivors [33,54,55].”
BackgroundThe impact of illness in patients with moderate to severe gastro-esophageal reflux disease
El-Dika, S. S., Guyatt, G. H., Armstrong, D., Degl’Innocenti, A., Wiklund, I. E., Fallone, C. A., Tanser, L., van Zanten, S. V., Heels-Ansdell, D., Wahlqvist, P., et al. (2005) · BMC Gastroenterology · doi:10.1186/1471-230x-5-23 · Cited by 29
“The health utility index 3 (HUI 3) is a multi attribute utility instrument designed to classify a patient's health status based on rating of a set of defined items [25,26].”
Migraine Frequency and Health Utilities: Findings from a Multisite Survey
Brown, J. S., Neumann, P. J., Papadopoulos, G., RUOFF, G. E., Diamond, M. L., & Menzin, J. (2007) · Value in Health · doi:10.1111/j.1524-4733.2007.00246.x · Cited by 29
The met and unmet health care needs of adult survivors of childhood central nervous system tumors
Hovén, E., Lannering, B., Gustafsson, G., & Boman, K. K. (2011) · Cancer · doi:10.1002/cncr.26020 · Cited by 29
“The HUI2/ 3 has proven to be applicable across age groups and in various clinical and nonclinical populations.(23,24) It allows for the establishment of an overall health status score, and this was used in the current study.”
MethodAdamo, K. B., Barrowman, N., Naylor, P., Yaya, S., Dingwall‐Harvey, A. L. J., Grattan, K. P., & Goldfield, G. S. (2014) · Trials · doi:10.1186/1745-6215-15-305 · Cited by 42
“Health-related utility will be measured using the validated EuroQol five dimensions questionnaire (EQ-5D) index [81-83], which is a widely used questionnaire for calculating quality-adjusted life-years for assessing cost-effectiveness in healthcare.”
MethodWhitehurst, D. G. T., Norman, R., Brazier, J. E., & Viney, R. C. (2014) · Value in Health · doi:10.1016/j.jval.2014.03.1720 · Cited by 29
“Currently, a number of different preference-based HRQOL measures are used to estimate patient benefit within economic evaluations, such as 15D [11], Assessment of Quality of Life (AQoL-4D, AQoL6D, and the AQoL-8D) [12,13], EQ-5D (three-level and five-level versions) [14,15], Health Utilities Index (Mark 2 and Mark 3)…”
BackgroundMethodExamining the Value of Menopausal Symptom Relief Among US Women
Craig, B. M., & Mitchell, S. A. (2015) · Value in Health · doi:10.1016/j.jval.2015.11.002 · Cited by 29
The classification systems of the EQ-5D, the HUI II and the SF-6D: what do they have in common?
Konerding, U., Moock, J., & Kohlmann, T. (2009) · Quality of Life Research · doi:10.1007/s11136-009-9525-8 · Cited by 29
“The mostly applied preference-based index instruments are the EQ-5D [1,2] and the HUI with its two newer versions HUI II and HUI III [3, 4].”
MethodRaat, H., Bonsel, G. J., Hoogeveen, W. C., & Essink‐Bot, M. (2003) · Medical Care · doi:10.1097/01.mlr.0000102297.06535.e7 · Cited by 29
Oberjé, E. J. M., Dima, A. L., van Hulzen, A. G. W., Prins, J. M., & de Bruin, M. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0880-2 · Cited by 28
“For HIV, like for many other chronic conditions, dozens of disease-specific HRQOL questionnaires have been developed [4], but also generic HRQOL questionnaires that generate health utilities are frequently used, such as the SF6D [5], EQ-5D [6], and Health Utility Index [7].”
BackgroundActive Treatment for Idiopathic Adolescent Scoliosis (ACTIvATeS): a feasibility study
Williams, M. A., Heine, P., Williamson, E. M., Toyé, F., Dritsaki, M., Petrou, S., Crossman, R., Lall, R., Barker, K. L., Fairbank, J. C. T., et al. (2015) · Health Technology Assessment · doi:10.3310/hta19550 · Cited by 29
Fú, L., Talsma, D., Báez, F., Bonilla, M., Moreno, B., de Spengler, M. A. C., Pena, A., Furlong, W. J., & Barr, R. D. (2006) · Journal of Pediatric Hematology/Oncology · doi:10.1097/00043426-200606000-00003 · Cited by 28
“Measurements of HRQL in survivors of cancer in childhood in Central America are similar to elsewhere in Latin America and have identified burdens of morbidity common to such survivors in industrialized countries.(11) Consequently, it would be valuable to include such measurements routinely in the uniform treatment pro…”
BackgroundMethodSelf-citationComparing the health of low income and less well educated groups in the United States and Canada
Eng, K. K., & Feeny, D. H. (2007) · Population Health Metrics · doi:10.1186/1478-7954-5-10 · Cited by 27
Self-citation
Metadata
- Authors
- Furlong, W. J., Feeny, D. H., Torrance, G. W., & Barr, R. D.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Furlong, William J
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 33
- Issue
- 5
- Pages
- 375-384
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2015583354
- Cited by
- 751
- References
- 79
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 32 · 2023: 21 · 2022: 26 · 2021: 21 · 2020: 27 · 2019: 14 · 2018: 37 · 2017: 32 · 2016: 27 · 2015: 29 · 2014: 38 · 2013: 40 · 2012: 40
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MacSphere (McMaster University) (submittedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Environmental Valuation
- Keywords
- Health Utilities Index, Health Utilities Index Mark 3, health-related quality of life, health status measurement, utility scores, multi-attribute utility function, cost-utility analysis, reference values, clinical trials
- MeSH terms
- Cost-Benefit Analysis, Cross-Sectional Studies, Health Status, Humans, Longitudinal Studies, Quality of Life, Reference Standards, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care
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