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The Health Utilities Index (HUI®) system for assessing health-related quality of life in clinical studies
Open accessAbstract
This paper reviews the Health Utilities Index (HUI) systems as means to describe health status and obtain utility scores reflecting health-related quality of life (HRQoL). The HUI Mark 2 (HUI2) and Mark 3 (HUI3) classification and scoring systems are described. The methods used to estimate multiattribute utility functions for HUI2 and HUI3 are reviewed. The use of HUI in clinical studies for a wide variety of conditions in a large number of countries is illustrated. HUI provides a comprehensive description of the health status of subjects in clinical studies. HUI has been shown to be a reliable, responsive and valid measure in a wide variety of clinical studies. Utility scores provide an overall assessment of the HRQoL of patients. Utility scores are also useful in cost-utility analyses and related studies. General population norm data are available. The widespread use of HUI facilitates the interpretation of results and permits comparisons. HUI is a useful tool for assessing health status and HRQoL in clinical studies.
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“The Health Utilities Index (HUI) provides indicators of multiple attributes of health status for use in economic evaluations of healthcare programmes. It has well-established validity and reliability in many clinical contexts (test–retest reliability of 0.767 intraclass correlation coefficient).77 78”
From Coached, Coordinated, Enhanced Neonatal Transition (CCENT): Protocol for a multicentre pragmatic randomised controlled trial of transition-to-home support for parents of high-risk infants (2021) · cites this paper as [77]
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Development and Use of Cognition Bolt-Ons for the EQ-5D-3L and EQ-5D-5L: A Systematic Review
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“Responses within each of the eight attributes can be valued as single attribute utility (SAU) scores on a scale ranging from 0 and 1 [51].”
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“However, the EQ5D, HUI and SF-6D focus narrowly on functional health status and do not incorporate the broad physical, psychological and social components that define HRQL. (ii) Generic measures often demonstrate a further lack of specificity (missing domains specific to signs and symptoms of a given disease or condit…”
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Metadata
- Authors
- Furlong, W. J., Feeny, D. H., Torrance, G. W., & Barr, R. D.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Furlong, William J
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 33
- Issue
- 5
- Pages
- 375-384
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2015583354
- Cited by
- 751
- References
- 79
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 32 · 2023: 21 · 2022: 26 · 2021: 21 · 2020: 27 · 2019: 14 · 2018: 37 · 2017: 32 · 2016: 27 · 2015: 29 · 2014: 38 · 2013: 40 · 2012: 40
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MacSphere (McMaster University) (submittedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Environmental Valuation
- Keywords
- Health Utilities Index, Health Utilities Index Mark 3, health-related quality of life, health status measurement, utility scores, multi-attribute utility function, cost-utility analysis, reference values, clinical trials
- MeSH terms
- Cost-Benefit Analysis, Cross-Sectional Studies, Health Status, Humans, Longitudinal Studies, Quality of Life, Reference Standards, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care
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