Longevity of man: relative weight and fatness in middle age
Abstract
By February, 1948, examinations in the Twin Cities Prospective Study were completed on 284 executive men, then aged 45-55 and "healthy". In 35 years 183 died, 110 were alive, one was lost. Entry body fatness, indicated by body mass index, skinfold thickness at three sites, relative girth, and body density, did not significantly discriminate the 35-year dead from survivors. Age at death was not related to any fatness measure. The multiple logistic equation in five solutions using age, blood pressure and smoking plus each fatness item separately, found no discrimination of dead from survivors by any fatness measure. In other long time prospective studies, two suggested excess mortality at far extremes of over- and under-weight, several found survivors significantly fatter than the dead, others found no relation between fatness and longevity. Framingham reported fatness a risk factor for death when allowance is made for smoking but that singular claim has been criticized.
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The original cohort was recruited from 1948 to 1952 and included 5209 residents aged 28 to 62 years.
“The original cohort was recruited between 1948 and 1952 and consisted of 5209 residents aged 28 to 62 years (Table 1).25”
From The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective (2014) · cites this paper as [25]
Thomas Dawber and William Kannel popularized the term 'risk factor' in the medical lexicon through their 1961 publication.
“Indeed, the term “risk factor” was popularized in the medical lexicon by Thomas Dawber and William Kannel by their 1961 publication, “Factors of Risk in the Development of Coronary Heart Disease.”25”
From The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective (2014) · cites this paper as [25]
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- Authors
- Keys, A.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Keys, Ancel
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 21
- Issue
- 3
- Pages
- 163-168
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2061977466
- Cited by
- 31
- References
- 30
- Citations by year
- 2023: 1 · 2021: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- longevity, adiposity, middle age (human life stage), mortality, body mass index, skinfold thickness, body density, smoking, blood pressure, age at death, Framingham Heart Study
- MeSH terms
- Body Weight, Cause of Death, Humans, Longevity, Male, Middle Aged, Minnesota, Obesity, Prospective Studies, Regression Analysis, Risk Factors, Time Factors, Cohort Studies
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