The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Abdominal Obesity and the Metabolic Syndrome
Abstract
Abdominal obesity in man is an integrated part of the Metabolic Syndrome, and is associated with a complex neuroendocrine disturbance. Its consequences for the metabolism of the periphery seems to be insulin resistance caused by a combination of a relative hypercortisolaemia and a relative deficiency of sex steroid hormones. This hormonal aberration, in combination with a relative insufficiency of growth hormone secretion, might also direct depot triglycerides to visceral adipose tissues, a consequence at least partly due to varying densities of the specific receptors for these hormones. Visceral fat accumulation may thus be a consequence of the neuroendocrine aberrations, and may amplify the metabolic symptoms via effects on the liver of free fatty acids released in abundance from the lipolytically sensitive enlarged visceral fat depots. The origin of the neuroendocrine disturbance is not known, but epidemiological and cross-sectional information suggest that psychosocial factors are intimately involved. Animal and human studies indicate that the mediating factor(s) may be stress-sensitivity, leading to the neuroendocrine consequences observed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recent studies have also suggested that visceral adiposity may play an important role in causing hepatic insulin resistance through its release of fatty acids and adipocytokines to the liver via the portal vein (28-31).”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [30]
Citations
Cites
"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.
Björntorp, P. A. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.4.493 · Cited by 1,115
Self-citationTreatment of adults with growth hormone (GH) deficiency with recombinant human GH.
Bengtsson, B. Å., Edén, S., Lönn, L., Kvist, H., Stokland, A. M., Lindstedt, G., Bosaeus, I. G., Tölli, J., Sjöström, L., & Isaksson, O. G. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432773 · Cited by 780
Cortisol secretion in relation to body fat distribution in obese premenopausal women
Mårin, P., Darin, N., Amemiya, T., Andersson, B., Jern, S., & Björntorp, P. (1992) · Metabolism · doi:10.1016/0026-0495(92)90171-6 · Cited by 458
Self-citationAdipose tissue distribution and function.
Carmelli, D., McElroy, M. R., & Rosenman, R. H. (1991) · PubMed · Cited by 315
Visceral fat accumulation: the missing link between psychosocial factors and cardiovascular disease?
Björntorp, P. A. (1991) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1991.tb00431.x · Cited by 283
Self-citationMuscle and Adipose Tissue Morphology and Metabolism in Cushing’s Syndrome*
Rebuffé-Scrive, M., Krotkiewski, M., Elfverson, J., & Björntorp, P. A. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-6-1122 · Cited by 262
Self-citationAbdominal Fat Distribution and Disease: An Overview of Epidemiological Data
Björntorp, P. A. (1992) · Annals of Medicine · doi:10.3109/07853899209164140 · Cited by 227
Self-citationObesity: Towards a molecular approach
(1989) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240410905 · Cited by 111
Psychosocial mechanisms of primary hypertension
Henry, J. P., & Grim, C. E. (1990) · Journal of Hypertension · doi:10.1097/00004872-199009000-00001 · Cited by 100
Metabolic abnormalities in visceral obesity
Björntorp, P. (1992) · Annals of Medicine · doi:10.3109/07853899209164137 · Cited by 50
Self-citation
Research works printed but not linked: 3
- Björntorp P, 1992, The relationship between ‘The Metabolic Syndrome’ and abdominal obesity in women
- Björntorp P, 1991, Int J Obes, 15, 67
- Björntorp P, 1992, Obesity in Europe, 377
Cited by
Sorted by citations
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Body Fat Distribution and Risk of Cardiovascular Disease: An Update
Després, J.-P. (2012) · Circulation · doi:10.1161/circulationaha.111.067264 · Cited by 1,481
Glycemic index: overview of implications in health and disease,,,
Jenkins, D. J., Kendall, C. W., Augustin, L. S., Franceschi, S., Hamidi, M., Marchie, A., Jenkins, A. L., & Axelsen, M. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.266s · Cited by 827
Progress and Challenges in Metabolic Syndrome in Children and Adolescents
Steinberger, J., Daniels, S. R., Eckel, R. H., Hayman, L. L., Lustig, R. H., McCrindle, B. W., & Mietus‐Snyder, M. (2009) · Circulation · doi:10.1161/circulationaha.108.191394 · Cited by 721
Metadata
- Authors
- Björntorp, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Björntorp, Per
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 24
- Issue
- 6
- Pages
- 465-468
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2025038536
- Cited by
- 233
- References
- 10
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 8 · 2012: 12
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- abdominal obesity, metabolic syndrome, insulin resistance, neuroendocrine dysfunction, hypercortisolism, sex hormone deficiency, growth hormone secretion, visceral adipose tissue, triglyceride deposition, free fatty acids, lipolysis, psychosocial factors, stress sensitivity
- MeSH terms
- Adipose Tissue, Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Metabolic Diseases, Neurosecretory Systems, Obesity, Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
