Metabolic abnormalities in visceral obesity
Abstract
In this brief overview the central role of the endocrine aberrations of visceral obesity has been emphasized. Indeed, it may provide not only a background to the pronounced insulin resistance seen in that condition, but also explain why lipid accumulates in visceral depots. It is possible that this lipid accumulation actually amplifies and widens the metabolic derangements via hepatic mechanisms induced by an excess of FFA in the portal vein. This chain of events has not been conclusively established. There is, however, considerable experimental support for several crucial parts of it, providing an interesting hypothesis for further work. Intervention studies will probably be of value for further evaluation and these are already being carried out.
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From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Bjorntorp, 1992
Cites
"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.
Björntorp, P. A. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.4.493 · Cited by 1,115 · see citing works
Self-citationThe Associations between Obesity, Adipose Tissue Distribution and Disease
Björntorp, P. A. (1987) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1987.tb05935.x · Cited by 400 · see citing works
Self-citationAdipose tissue distribution and function.
Carmelli, D., McElroy, M. R., & Rosenman, R. H. (1991) · PubMed · Cited by 320 · see citing works
Abdominal obesity and the development of noninsulin‐dependent diabetes mellitus
Björntorp, P. A. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040607 · Cited by 292 · see citing works
Self-citationFrontiers of diabetes research: current trends in non-insulin-dependent diabetes mellitus
Alberti, K., & Mazze, R. S. (1989) · Cited by 30 · see citing works
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Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review.
Kaaks, R., Lukanova, A., & Kurzer, M. S. (2002) · PubMed · Cited by 1,038 · see citing works
Cinti, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 690 · see citing works
Gastaldelli, A., Cusi, K., Pettiti, M., Hardies, J., Miyazaki, Y., Berria, R., Buzzigoli, E., Sironi, A. M., Cersosimo, E., Ferrannini, E., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.068 · Cited by 629 · see citing works
Stress as a Common Risk Factor for Obesity and Addiction
Sinha, R., & Jastreboff, A. M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.032 · Cited by 611 · see citing works
Adipokines as novel biomarkers and regulators of the metabolic syndrome
Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 577 · see citing works
Sex Differences in Body Composition
Bredella, M. A. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-70178-3_2 · Cited by 523 · see citing works
Nutrition, hormones, and breast cancer: Is insulin the missing link?
Kaaks, R. (1996) · Cancer Causes & Control · doi:10.1007/bf00051703 · Cited by 361 · see citing works
Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects
Lihn, A. S., Bruun, J. M., He, G., Pedersen, S. B., Jensen, P. F., & Richelsen, B. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.03.002 · Cited by 321 · see citing works
Pathophysiology and types of dyslipidemia in PCOS
Diamanti‐Kandarakis, E., Papavassiliou, A. G., Kandarakis, S., & Chrousos, G. P. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.07.004 · Cited by 301 · see citing works
Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0945 · Cited by 279 · see citing works
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 289 · see citing works
Sexual differences in the control of energy homeostasis
Shi, H., Seeley, R. J., & Clegg, D. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.004 · Cited by 242 · see citing works
“subcutaneous fat—The increased health risks due to obesity vary depending on the location / accrual of adipose tissue [15], [16], [17], [19] and [123].”
BackgroundAbdominal Obesity and the Metabolic Syndrome
Björntorp, P. (1992) · Annals of Medicine · doi:10.3109/07853899209166997 · Cited by 233 · see citing works
Self-citationConvertible visceral fat as a therapeutic target to curb obesity
Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 236 · see citing works
Role of addiction and stress neurobiology on food intake and obesity
Sinha, R. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2017.05.001 · Cited by 211 · see citing works
Between brown and white: Novel aspects of adipocyte differentiation
Cinti, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.535557 · Cited by 161 · see citing works
Sex differences in metabolism and cardiometabolic disorders
Krishnan, K. C., Mehrabian, M., & Lusis, A. J. (2018) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000536 · Cited by 142 · see citing works
The effects of old, new and emerging medicines on metabolic aberrations in PCOS
Bargiota, Α., & Diamanti‐Kandarakis, E. (2012) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018812437355 · Cited by 118 · see citing works
Ek, I., Arner, P., Bergqvist, A., Carlström, K., & Wahrenberg, H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.4.3899 · Cited by 116 · see citing works
Gottschlich, M., Mayes, T., Khoury, J., & Warden, G. (1993) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(93)91952-m · Cited by 108 · see citing works
Hellström, L., Large, V., Reynisdottir, S., Wahrenberg, H., & Arner, P. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.0437e.x · Cited by 99 · see citing works
Role of the gut in visceral fat inflammation and metabolic disorders
Lam, Y. Y., Mitchell, A. J., Holmes, A. J., Denyer, G. S., Gummesson, A., Caterson, I. D., Hunt, N. H., & Storlien, L. H. (2011) · Obesity · doi:10.1038/oby.2011.68 · Cited by 97 · see citing works
Abnormalities in glucose regulation associated with mental illness and treatment
Haupt, D. W., & Newcomer, J. W. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00471-3 · Cited by 70 · see citing works
El-Haleim, E. A. A., Bahgat, A. K., & Saleh, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i10.2931 · Cited by 68 · see citing works
Artificial Intelligence in the Evaluation of Body Composition
Wang, B., & Torriani, M. (2020) · Seminars in Musculoskeletal Radiology · doi:10.1055/s-0039-3400267 · Cited by 42 · see citing works
Visceral Adipocytes and the Metabolic Syndrome
Tchernof, A. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00324.x · Cited by 38 · see citing works
A Critical Review on Obesity: Herbal Approach, Bioactive Compounds, and Their Mechanism
Kumar, M., Kaushik, D., Kaur, J., Proestos, C., Öz, F., Öz, E., Gupta, P., Kundu, P., Kaur, A., Anisha, A., et al. (2022) · Applied Sciences · doi:10.3390/app12168342 · Cited by 38 · see citing works
Hershberger, A. M., McCammon, M. R., Garry, J. P., Mahar, M. T., & Hickner, R. C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031144 · Cited by 34 · see citing works
Wang, J., Gao, H., Ke, D., Zuo, G., Yang, Y., Yamahara, J., & Li, Y. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/590376 · Cited by 33 · see citing works
Obesity, Endogenous Hormones, and Endometrial Cancer Risk
Kaaks, R., Lukanova, A., & Kurzer, M. S. (2002) · Cancer Epidemiology and Prevention Biomarkers · Cited by 22 · see citing works
Section III: Practical Considerations in the Management of Depression in Diabetes
Lustman, P. J., & Clouse, R. E. (2004) · Diabetes Spectrum · doi:10.2337/diaspect.17.3.160 · Cited by 21 · see citing works
Luca, T., Pezzino, S., Puleo, S., & Castorina, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05547-3 · Cited by 19 · see citing works
The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19
Cinti, F., & Cinti, S. (2022) · Cells · doi:10.3390/cells11132109 · Cited by 17 · see citing works
Visceral Fat and Adiponectin: Associations with Insulin Resistance Are Tissue-Specific in Women
Coker, R. H., Williams, R. H., Yeo, S. E., KORTEBEIN, P. M., Bodenner, D. L., Kern, P. A., & Evans, W. J. (2008) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0035 · Cited by 16 · see citing works
Sex Differences in Energy Balance, Body Composition, and Body Fat Distribution
Tchernof, A. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-250-6_1 · Cited by 10 · see citing works
Sadashiv, Tiwari, S., Paul, B. N., Kumar, S., Chandra, A., Dhananjai, S., & Negi, M. P. S. (2013) · HORMONES · doi:10.1007/bf03401293 · Cited by 8 · see citing works
Reduction of Visceral Adiposity After Operation in a Subject with Insulinoma
Saiki, A., Miyashita, Y., Wakabayasi, K., Kameda, N., & Shirai, K. (2004) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11.209 · Cited by 6 · see citing works
Sex Differences in Obesity-Induced Inflammation
Terrazas, S., Brashear, L., Escoto, A.-K., Lynch, S. E., Slaughter, D., Xavier, N., Estes, N. R., & Giordano‐Mooga, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84941 · Cited by 6 · see citing works
Obesity and Dyslipidemia: Importance of Body Fat Distribution
Tchernof, A., & Després, J. (2009) · Wiley eBooks · doi:10.1002/9781444307627.ch13 · Cited by 2 · see citing works
Selvaraj, R. K., Jeyabalan, S., Vasu, S., Palaniyappan, V., & Settu, S. (2021) · INDIAN DRUGS · doi:10.53879/id.58.07.11836 · Cited by 1 · see citing works
The effect of 10- versus 30-minutes of acute aerobic exercise on insulin and glucose in obese adults
Mishler, A. E. (2012) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1 · see citing works
Abdominal Obesity (Metabolic Syndrome)
DEEN, D. (2006) · Elsevier eBooks · doi:10.1016/b978-1-4160-2377-7.50051-3 · Cited by 1 · see citing works
Polycystic ovary syndrome: ovarian pathophysiology and consequences after the menopause
Schmidt, J. G. H. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1 · see citing works
Obesity and Dyslipidaemia: Importance of Body Fat Distribution
Tchernof, A., & Després, J. (2005) · Wiley eBooks · doi:10.1002/9780470987087.ch12 · Cited by 1 · see citing works
Cinti, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1203-2_6
Benoit, S. C., Clegg, D. J., & Woods, S. C. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_16
DHEA, Obesity and Cardiovascular Disease
Tchernof, A., Labrie, F., & Després, J. (2011) · De Gruyter eBooks · doi:10.1515/9783110811162.191
Vettor, R., & Cinti, S. (2009) · Oxidative stress and disease · doi:10.1201/9781420091311.ch1
- Authors
- Björntorp, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Björntorp, Per
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 24
- Issue
- 1
- Pages
- 3-5
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2074686166
- Cited by
- 50
- References
- 5
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- visceral obesity, metabolic abnormalities, insulin resistance, lipid accumulation, visceral adipose tissue, free fatty acids, hepatic lipid metabolism, portal vein, metabolic disorders
- MeSH terms
- Abdomen, Adipose Tissue, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Insulin Resistance, Lipolysis, Male, Obesity, Progesterone, Testosterone
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