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Cited by 894

The DOI matches its Crossref record; 305 of the 305 references it cites were found in a registry or an index.

Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document

Mancia, Giuseppe, Laurent, Stéphane, Agabiti-Rosei, Enrico, Ambrosioni, Ettore, Burnier, Michel, Caulfield, Mark J., Cifkova, Renata, Clément, Denis, Coca, Antonio, Dominiczak, Anna, Erdine, Serap, Fagard, Robert, Farsang, Csaba, Grassi, Guido, Haller, Hermann, Heagerty, Antony, Kjeldsen, Sverre E., Kiowski, Wolfgang, Mallion, Jean Michel, Manolis, Athanasios, Narkiewicz, Krzysztof, Nilsson, Peter, Olsen, Michael H., Rahn, Karl Heinz, Redon, Josep, Rodicio, José, Ruilope, Luis, Schmieder, Roland E., Struijker-Boudier, Harry A.J., Van Zwieten, Pieter A., Viigimaa, Margus, Zanchetti, Alberto·2009·Blood Pressure

Abstract

Many important decisions on hypertension management must currently be taken without the support of evidence \nfrom large randomized controlled trials. The following issues appear in urgent need to be approached by simply \ndesigned trials. \n(1) Should antihypertensive drugs be prescribed to all patients with grade 1 hypertension, even when total \ncardiovascular risk is relatively low or moderate? Because of the very low rate of cardiovascular events \nexpected in these patients, a placebo-controlled trial using intermediate endpoints such as signs of organ \ndamage of recognized prognostic importance would be feasible, ethical, and clinically relevant. \n(2) Should antihypertensive drugs be prescribed to the elderly with grade 1 hypertension, and should antihypertensive \ntreatment achieve a goal of below 140/90mmHg also in the elderly? These trials could make use \nof hard cardiovascular outcomes and could be placebo-controlled. \n(3) Should antihypertensive drug treatment be started in diabetic patients or in patients with previous cerebrovascular \nor cardiovascular disease when BP is still in the high normal level, and should BP goal be below 130/ \n80mmHg in these patients? These issues can be approached by placebo-controlled trials because no trial \nevidence is still available on the benefit of lowering high normal BP or of achieving BP goals below 130/ \n80mmHg. \n(4) What are the lowest safe BP values to achieve by treatment in different clinical conditions? This issue should \nbe approached by trials comparing more or less intense BP-lowering treatment strategies in patients with \ndifferent cardiovascular risk levels. \n(5) Are lifestyle measures known to reduce BP also capable of reducing morbidity and mortality in hypertension? \nA controlled randomized trial using intermediate endpoints (organ damage) would be feasible and desirable \nin patients with high normal BP or grade 1 hypertension.

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Metadata

Authors
Mancia, G., Laurent, S., Agabiti-Rosei, E., Ambrosioni, E., Burnier, M., Caulfield, M. J., Cifkova, R., Clément, D., Coca, A., Dominiczak, A., Erdine, S., Fagard, R., Farsang, C., Grassi, G., Haller, H., Heagerty, A., Kjeldsen, S. E., Kiowski, W., Mallion, J. M., Manolis, A., Narkiewicz, K., Nilsson, P., Olsen, M. H., Rahn, K. H., Redon, J., Rodicio, J., Ruilope, L., Schmieder, R. E., Struijker-Boudier, H. A. J., Van Zwieten, P. A., Viigimaa, M., & Zanchetti, A.
Venue
Blood Pressure
Published
2009-01
Volume
18
Issue
6
Pages
308-347
ISSN
  • 0803-7051 (ISSN-L)
  • 1651-1999
OpenAlex
W1988716175
Cited by
894
References
305
FWCI
88.18
Type
journal article
Language
en
Open access
closed

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Mancia, G., Laurent, S., Agabiti-Rosei, E., Ambrosioni, E., Burnier, M., Caulfield, M. J., Cifkova, R., Clément, D., Coca, A., Dominiczak, A., Erdine, S., Fagard, R., Farsang, C., Grassi, G., Haller, H., Heagerty, A., Kjeldsen, S. E., Kiowski, W., Mallion, J. M., . . . Zanchetti, A. (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Blood Pressure. https://doi.org/10.3109/08037050903450468

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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