The DOI matches its Crossref record; 397 of the 397 references it cites were found in a registry or an index.
The role of cytokines in inflammatory bone loss
Abstract
Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is mainly due to local formation of bone resorbing osteoclasts which degrade bone without any subsequent coupling to new bone formation. Crucial for osteoclastogenesis is stimulation of mononuclear osteoclast progenitors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) which induces their differentiation along the osteoclastic lineage and the fusion to mature, multinucleated osteoclasts. M-CSF and RANKL are produced by osteoblasts/osteocytes and by synovial and periodontal fibroblasts and the expression is regulated by pro- and anti-inflammatory cytokines. These cytokines also regulate osteoclastic differentiation by direct effects on the progenitor cells. In the present overview, we introduce the basic concepts of osteoclast progenitor cell differentiation and summarize the current knowledge on cytokines stimulating and inhibiting osteoclastogenesis by direct and indirect mechanisms.
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Cited by
Macrophage Polarization and Osteoporosis: A Review
Muñoz, J., Akhavan, N. S., Mullins, A. P., & Arjmandi, B. H. (2020) · Nutrients · doi:10.3390/nu12102999 · Cited by 384
Zhang, B., Yang, Y., Yi, J., Zhao, Z., & Ye, R. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12912 · Cited by 253
Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation
Souza, P. P. C., & Lerner, U. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01663 · Cited by 67
“Anothermechanism may be due to increased expression of osteoclast-stimulating cytokines (16).”
BackgroundInfluentialSelf-citationIs Peri-Implant Probing Causing Over-Diagnosis and Over-Treatment of Dental Implants?
Coli, P., & Sennerby, L. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081123 · Cited by 55
Ma, T.-L., Zhu, P., Ke, Z.-R., Chen, J.-X., Hu, Y.-H., & Xie, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.891313 · Cited by 9
Metadata
- Authors
- Souza, P. P. C., & Lerner, U. H.
- Venue
- Immunological Investigations
- Publisher
- Informa UK Limited
- Published
- 2013-09-05
- Volume
- 42
- Issue
- 7
- Pages
- 555-622
- ISSN
- 0882-0139 (ISSN-L)
- 1532-4311
- OpenAlex
- W2045068030
- Cited by
- 269
- References
- 397
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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