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Mechanisms of type-I- and type-II-interferon-mediated signalling
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Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600
Regulation of translation initiation by FRAP/mTOR
Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545
Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
Schindler, C., Shuai, K., Prezioso, V. R., & Darnell, J. E. (1992) · Science · doi:10.1126/science.1496401 · Cited by 899
Insulin signaling in health and disease
White, M. F. (2003) · Science · doi:10.1126/science.1092952 · Cited by 733 · cited 1×
“These tyrosine residues are present in specific motifs such that, when phosphorylated, they function as binding sites for various signalling proteins that contain SH2 domains, including the p85 regulatory subunit of PI3”
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- Pestka, S., Langer, J. A., Zoon, K. C. & Samuel, C. E. Interferons and their actions. Annu. Rev. Biochem. 56, 727–777 (1987). · DOI · Paper page
- Pestka, S., Krause, C. D. & Walter, M. R. Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 202, 8–32 (2004). · DOI · Paper page
- Pestka, S. The human interferon α species and hybrid proteins. Semin. Oncol. 24, S9-4–S9-17 (1997).
- Chen, J., Baig, E. & Fish, E. N. Diversity and relatedness among the type I interferons. J. Interfon Cytokine Res. 24, 687–698 (2004). · DOI
- Platanias, L. C. & Fish, E. N. Signaling pathways activated by interferons. Exp. Hematol. 27, 1583–1592 (1999). · DOI · Paper page
- Parmar, S. & Platanias, L. C. Interferons: mechanisms of action and clinical applications. Curr. Opin. Oncol. 15, 431–439 (2003). · DOI
- Pestka, S. et al. The interferon γ (IFN-γ) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 8, 189–206 (1997). · DOI
- Bach, E. A., Aguet, M. & Schreiber, R. D. The IFN γ receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15, 563–591 (1997). · DOI · Paper page
- Kotenko, S. V. et al. IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex. Nature Immunol. 4, 69–77 (2003). · DOI · Paper page
- Ihle, J. N. The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv. Immunol. 60, 1–35 (1995). · DOI · Paper page
- Platanias, L. C. The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol. Ther. 98, 129–142 (2003). · DOI · Paper page
- Der, S. D., Zhou, A., Williams, B. R. & Silverman, R. H. Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays. Proc. Natl Acad. Sci. USA 95, 15623–15628 (1998). · DOI · Paper page
- Fu, X. Y., Schindler, C., Improta, T., Aebersold, R. & Darnell, J. E. The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl Acad. Sci. USA 89, 7840–7843 (1992). · DOI · Paper page
- Shuai, K., Schindler, C., Prezioso, V. R. & Darnell, J. E. Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258, 1808–1812 (1992). · DOI · Paper page
- Silvennoinen, O., Ihle, J. N., Schlessinger, J. & Levy, D. E. Interferon-induced nuclear signaling by Jak protein tyrosine kinases. Nature 366, 583–585 (1993). · DOI · Paper page
- Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H. & Schreiber, R. D. How cells respond to interferons. Annu. Rev. Biochem. 67, 227–264 (1998). · DOI · Paper page
- Darnell, J. E. Stats and gene regulation. Science 277, 1630–1635 (1997). An excellent review of the mechanisms of STAT activation and the regulatory effects of STATs on gene transcription. · DOI · Paper page
- Aaronson, D. S. & Horvath C. M. A road map for those who don't know JAK–STAT. Science 296, 1653–1655 (2002). · DOI · Paper page
- Meinke, A., Barahmand-Pour, F., Wohrl, S., Stoiber, D. & Decker, T. Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons. Mol. Cell. Biol. 16, 6937–6944 (1996). · DOI · Paper page
- Farrar, J. D., Smith, J. D., Murphy, T. L. & Murphy, K. M. Recruitment of Stat4 to the human interferon-α/β receptor requires activated Stat2. J. Biol. Chem. 275, 2693–2697 (2000). · DOI
- Torpey, N., Maher, S. E., Bothwell, A. L. & Pober, J. S. Interferon α but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells. J. Biol. Chem. 279, 26789–26796 (2004). · DOI
- Matikainen, S. et al. Interferon-α activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells. Blood 93, 1980–1991 (1999). · DOI · Paper page
- Fasler-Kan, E., Pansky, A., Wiederkehr, M., Battegay, M. & Heim, M. H. Interferon-α activates signal transducers and activators of transcription 5 and 6 in Daudi cells. Eur. J. Biochem. 254, 514–519 (1998). · DOI
- Nguyen, K. B. et al. Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection. Science 297, 2063–2066 (2002). · DOI · Paper page
- Wen, Z. & Darnell, J. E. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 25, 2062–2067 (1997). · DOI · Paper page
- Uddin, S. et al. Protein kinase C-δ (PKC-δ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J. Biol. Chem. 277, 14408–14416 (2002). The first identification of PKC-δ as an IFN-activated kinase that regulates the phosphorylation of STAT1 on Ser727. · DOI · Paper page
- Deb, D. K. et al. Activation of protein kinase C δ by IFN-γ. J. Immunol. 171, 267–273 (2003). · DOI
- Kristof, A. S., Marks-Konczalik, J., Billings, E. & Moss, J. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-γ is regulated by mammalian target of rapamycin. J. Biol. Chem. 278, 33637–33644 (2003). · DOI
- Choudhury, G. G. A linear signal transduction pathway involving phosphatidylinositol 3-kinase, protein kinase C-ε, and MAPK in mesangial cells regulates interferon-γ-induced STAT1α transcriptional activation. J. Biol. Chem. 279, 27399–27409 (2004). · DOI
- Nair, J. S. et al. Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-γ. Proc. Natl Acad. Sci. USA 99, 5971–5976 (2002). · DOI
- Zhang, J. J. et al. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling. Proc. Natl Acad. Sci. USA 93, 15092–15096 (1996). · DOI · Paper page
- Bhattacharya, S. et al. Cooperation of Stat2 and p300/CBP in signaling induced by interferon-α. Nature 383, 344–347 (1996). · DOI · Paper page
- Zhang, J. J. et al. Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation. EMBO J. 17, 6963–6971 (1998). · DOI · Paper page
- DaFonseca, C. J., Shu, F. & Zhang, J. J. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-γ. Proc. Natl Acad. Sci. USA 98, 3034–3039 (2001). · DOI
- Hebbes, T. R., Thorne, A. W. & Crane-Robinson, C. A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J. 7, 1395–1402 (1988). · DOI · Paper page
- Paulson, M., Press, C., Smith, E., Tanese, E. & Levy, D. E. IFN-stimulated transcription through a TBP- free acetyltransferase complex escapes viral shutoff. Nature Cell Biol. 4, 140–147 (2002). · DOI
- Huang, M. et al. Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-α-inducible genes. Nature Cell Biol. 4, 774–781 (2002). · DOI
- Zhu, M., John, S., Berg, M. & Leonard, W. J. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling. Cell 96, 121–130 (1999). · DOI · Paper page
- Nusinzon, I. & Horvath, C. M. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Natl Acad. Sci. USA 100, 14742–14747 (2003). The first evidence that histone-deacetylase activity is required for IFN-dependent transcription. · DOI · Paper page
- Chang, H. M. et al. Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Proc. Natl Acad. Sci. USA 101, 9578–9583 (2004). · DOI · Paper page
- Sakamoto, S., Potla, R. & Larner, A. C. Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. J. Biol. Chem. 279, 40362–40367 (2004). · DOI
- Mayer, B. J., Hamaguchi, M. & Hanafusa, H. A novel viral oncogene with structural homology to phospholipase C. Nature 332, 272–275 (1988). · DOI · Paper page
- Feller, S. M. Crk family adaptors — signaling complex formation and biological roles. Oncogene 20, 6348–6371 (2001). · DOI · Paper page
- Ahmad, S., Alsayed, Y., Druker, B. J. & Platanias, L. C. The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. J. Biol. Chem. 272, 29991–29994 (1997). · DOI
- Alsayed, Y. et al. Interferon-γ activates the C3G/Rap1 signaling pathway. J. Immunol. 164, 1800–1806 (2000). · DOI
- Stork, P. J. Does Rap1 deserve a bad Rap? Trends Biochem. Sci. 28, 267–275 (2003). · DOI
- Bos, J. L., de Rooij, J. & Reedquist, K. A. Rap1 signaling: adhering to new models. Nature Rev. Mol. Cell Biol. 2, 369–377 (2001). · DOI · Paper page
- Kitayama, H., Sugimoto, Y., Matsuzaki, T., Ikawa, Y. & Noda, M. A ras-related gene with transformation suppressor activity. Cell 56, 77–84 (1989). · DOI · Paper page
- Schmitt, J. M. & Stork, P. J. Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1. Mol. Cell. Biol. 21, 3671–3683 (2001). · DOI · Paper page
- Lahlou, H. et al. sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation. J. Biol. Chem. 278, 39356–39371 (2003). · DOI
- Hattori, M. & Minato, N. Rap1 GTPase: functions, regulation and malignancy. J. Biochem. 134, 479–484 (2003). · DOI · Paper page
- Lekmine, F. et al. The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1. Biochem. Biophys. Res. Commun. 291, 744–750 (2002). · DOI
- Platanias, L. C. et al. CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors. Exp. Hematol. 27, 1315–1321 (1999). · DOI
- Huang, C. C., You, J. L., Wu, M. Y. & Hsu, K. S. Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI•Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long-term depression. J. Biol. Chem. 279, 12286–12292 (2004). · DOI · Paper page
- Katagiri, K. et al. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nature Immunol. 5, 1045–1051 (2004). · DOI · Paper page
- Fish, E. N. et al. Activation of a CrkL–Stat5 signaling complex by type I interferons. J. Biol. Chem. 274, 571–573 (1999). The first report that CRKL forms DNA-binding complexes with STAT5 and functions as a nuclear adaptor for STAT5 in type-I-IFN-mediated signalling. · DOI
- Grumbach, I. M. et al. Engagement of the CrkL adapter in interferon α signaling in BCR–ABL expressing cells. Br. J. Haematol. 112, 327–336 (2001). · doi:10.1046/j.1365-2141.2001.02556.x
- Takahashi, Y., Lallemand-Breitenbach, V., Zhu, J. & de The, H. PML nuclear bodies and apoptosis. Oncogene 23, 2819–2824 (2004). · DOI
- Uddin, S. et al. Role of Stat5 in type I interferon-signaling and transcriptional regulation. Biochem. Biophys. Res. Commun. 308, 325–330 (2003). · DOI
- Chang, L. & Karin, M. Mammalian MAP kinase signaling cascades. Nature 410, 37–40 (2001). · DOI · Paper page
- Dong, C., Davis, R. J. & Flavell, R. A. MAP kinases in the immune response. Annu. Rev. Immunol. 20, 55–72 (2002). · DOI · Paper page
- Hazzalin, C. A. & Mahadevan, L. C. MAPK-regulated transcription: a continuously variable gene switch? Nature Rev. Mol. Cell Biol. 3, 30–40 (2002). · DOI · Paper page
- Platanias, L. C. Map kinase signaling pathways and hematologic malignancies. Blood 101, 4667–4679 (2003). · DOI · Paper page
- Uddin, S. et al. Activation of the p38 Map kinase by type I interferons. J. Biol. Chem. 274, 30127–30131 (1999). · DOI · Paper page
- Goh, K. C., Haque, S. J. & Williams, B. R. p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J. 18, 5601–5608 (1999). · DOI · Paper page
- Uddin, S. et al. The Rac1/p38 Map kinase pathway is required for IFNα-dependent transcriptional activation but not serine phosphorylation of Stat-proteins. J. Biol. Chem. 275, 27634–27640 (2000). · DOI
- Kovarik, P. et al. Stress-induced phosphorylation of Stat1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different pathway. Proc. Natl Acad. Sci. USA 96, 13956–13961 (1999). · DOI · Paper page
- Li, Y. et al. Role of p38α Map kinase in type I interferon signaling. J. Biol. Chem. 279, 970–979 (2004). Definitive evidence that the type-I-IFN-activated p38-signalling pathway is required for transcriptional regulation. · DOI
- Ramsauer, K. et al. p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation. Proc. Natl Acad. Sci. USA 99, 12859–12864 (2002). · DOI
- Crespo, P., Schuebel, K. E., Ostrom, A. A., Gutkind, J. S. & Bustelo, X. R. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385, 169–172 (1997). · DOI · Paper page
- Bustelo, X. R. Regulatory and signaling properties of the Vav family. Mol. Cell. Biol. 20, 1461–1477 (2000). · DOI · Paper page
- Platanias, L. C. & Sweet, M. E. Interferon α induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells. J. Biol. Chem. 269, 3143–3146 (1994). · DOI
- Micouin, A., Wietzrbin, J., Steunou, V. & Martyre, M. C. p95Vav is associated to the IFNα/β receptor and contributes to the antiproliferative effect of IFNα in megacaryocytic cell lines. Oncogene 19, 387–394 (2000). · doi:10.1038/sj.onc.1203314
- Uddin, S., Sweet, M. E., Colamonici, O. R., Krolewski, J. J. & Platanias, L. C. The vav proto-oncogene product interacts with the Tyk-2 tyrosine kinase. FEBS Lett. 403, 31–34 (1997). · DOI
- Li, Y. et al. Activation of Mkk3 and Mkk6 by type I interferons. J. Biol. Chem. 280, 10001–10010 (2005). · DOI
- Kotlyarov, A. & Gaestel, M. Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression? Biochem. Soc. Trans. 30, 959–963 (2002). · DOI
- Deak, M., Clifton A. D., Lucocq, L. M. & Alessi, D. R. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17, 4426–4441 (1998). · DOI · Paper page
- Soloaga, A. et al. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 22, 2788–2797 (2003). · DOI · Paper page
- Clayton, A. L. & Mahadevan, L. C. MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Lett. 546, 51–58 (2003). · DOI · Paper page
- Waskiewicz, A. J., Flynn, A., Proud, C. G. & Cooper, J. A. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16, 1909–1920 (1997). · DOI · Paper page
- Knauf, U., Tschopp, C. & Gram, H. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol. Cell. Biol. 21, 5500–5511 (2001). · DOI
- Mayer, I. A. et al. The p38 MAPK pathway mediates the growth inhibitory effects of interferon-α in BCR–ABL-expressing cells. J. Biol. Chem. 276, 28570–28577 (2001). · DOI
- Verma, A. et al. Activation of the p38 Map kinase pathway mediates the suppressive effects of type I interferons and transforming growth factor β on normal hematopoiesis. J. Biol. Chem. 277, 7726–7735 (2002). · DOI · Paper page
- Ishida, H. et al. Involvement of p38 signaling pathway in interferon-α-mediated antiviral activity towards hepatitis C virus. Biochem. Biophys. Res. Commun. 321, 722–727 (2004). · DOI
- David, M. et al. Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through STAT proteins. Science 269, 1721–1723 (1995). · DOI · Paper page
- Hu, J. et al. ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-β-dependent gene transcription in response to interferon-γ. J. Biol. Chem. 276, 287–297 (2001). · DOI
- Wang, F. et al. Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier. Nature Immunol. 5, 1266–1274 (2004). · DOI
- Roy, S. K. et al. MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ. Proc. Natl Acad. Sci. USA 99, 7945–7950 (2002). · DOI
- Roy, S. K., Wachira, S. J., Weihua, X., Hu, J. & Kalvakolanu, D. V. CCAAT/enhancer-binding protein-β regulates interferon-induced transcription through a novel element. J. Biol. Chem. 275, 12626–12632 (2000). · DOI
- Floyd, Z. E. & Stephens, J. M. Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes. J. Biol. Chem. 277, 4062–4068 (2002). · DOI
- Li, C. et al. IFNα induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras–Erk signaling. Oncogene 23, 1608–1617 (2004). · DOI
- Li, G., Xiang, Y., Sabapathy, K. & Silverman, R. H. An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase. J. Biol. Chem. 279, 1123–1131 (2004). · DOI
- Uddin, S. et al. Interferon-α engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3′-kinase. J. Biol. Chem. 270, 15938–159341 (1995). · DOI
- Platanias, L. C. et al. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J. Biol. Chem. 271, 278–282 (1996). · DOI
- Burfoot, M. S. et al. Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J. Biol. Chem. 272, 24183–24190 (1997). · DOI
- Uddin, S. et al. The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-α receptors. Blood 90, 2574–2582 (1997).
- Uddin, S. et al. Interferon-dependent activation of the serine kinase PI 3′-kinase requires engagement of the IRS pathway but not the Stat pathway. Biochem. Biophys. Res. Commun. 270, 158–162 (2000). · DOI
- Uddin, S. et al. Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-α. J. Immunol. 158, 2390–2397 (1997). · DOI
- Cengel, K. A. & Freund, G. G. JAK1-dependent phosphorylation of insulin receptor substrate-1 (IRS-1) is inhibited by IRS-1 serine phosphorylation. J. Biol. Chem. 274, 27969–27974 (1999). · DOI
- Nguyen, H., Ramana, C. V., Bayes, J. & Stark, G. R. Roles of phosphatidylinositol 3-kinase in interferon-γ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. J. Biol. Chem. 276, 33361–33368 (2001). · DOI
- DeVries, T. A., Rachelle, L., Kalkofen, A., Matassa, A. & Reyland, M. E. Protein kinase Cδ regulates apoptosis via activation of STAT1. J. Biol. Chem. 279, 45603–45612 (2004). · DOI
- Lu, Z. et al. Tumor promotion by depleting cells of protein kinase C-δ. Mol. Cell. Biol. 17, 3418–3428 (1997). · DOI · Paper page
- Redding, P. J. et al. Transgenic mice overexpressing protein kinase C δ in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 59, 5710–5718 (1999).
- Srivastava, K. K. et al. Engagement of protein kinase C-θ in interferon signaling in T-cells. J. Biol. Chem. 279, 29911–29920 (2004). · DOI
- Vivanco, I. & Sawyers, C. L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Rev. Cancer 2, 489–501 (2002). · DOI · Paper page
- Barca, O. et al. Interferon β promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. J. Neuroimmunol. 139, 155–159 (2003). · DOI
- Ruuth, K., Carlsson, L., Hallberg, B. & Lundgren, E. Interferon-α promotes survival of human primary B-lymphocytes via phosphatidylinositol 3-kinase. Biochem. Biophys. Res. Commun. 284, 583–586 (2001). · DOI
- Wang, K. et al. Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-δ, and NF-κB signaling pathways. J. Immunol. 171, 1035–1041 (2003). · DOI
- Yang, C. H. et al. Interferon α/β promotes cell survival by activating nuclear factor κB through phosphatidylinositol 3-kinase and Akt. J. Biol. Chem. 276, 13756–13761 (2001). · DOI
- Thyrell, L. et al. Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J. Biol. Chem. 279, 24152–24162 (2004). · DOI
- Hwang, S. Y. et al. LY294002 inhibits interferon-γ-stimulated inducible nitric oxide synthase expression in BV2 microglial cells. Biochem. Biophys. Res. Commun. 318, 691–697 (2004). · DOI
- Navarro, A., Anand-Apte, B., Tanabe, Y., Feldman, G. & Larner, A. C. A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion. J. Leukoc. Biol. 73, 540–545 (2003). · DOI
- Rani, M. R., Hibbert, L., Sizemore, N., Stark, G. R. & Ransohoff, R. M. Requirement of phosphoinositide 3-kinase and Akt for interferon-β-mediated induction of the β-R1 (SCYB11) gene. J. Biol. Chem. 277, 38456–38461 (2002). · DOI
- Marcus, P. I. & Salb, J. M. Molecular basis of interferon action: inhibition of viral RNA translation. Virology 30, 502–516 (1966). · doi:10.1016/0042-6822(66)90126-7
- Doualla-Bell, F. & Koromilas, A. E. Induction of PG G/H synthase-2 in bovine myometrial cells by interferon-τ requires the activation of the p38 MAPK pathway. Endocrinology 142, 5107–5115 (2001). · DOI
- Lekmine, F. et al. Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J. Biol. Chem. 278, 27772–27780 (2003). The first report that type I IFNs activate pathways for the initiation of mRNA translation that are downstream of MTOR. · DOI
- Lekmine, F. et al. Interferon-γ engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp. Cell Res. 295, 173–182 (2004). · DOI
- Hay, N. & Sonenberg, N. Upstream and downstream of mTOR. Genes Dev. 18, 1926–1945 (2004). A comprehensive review of MTOR and the regulation of signals for mRNA translation. · DOI · Paper page
- Bjornsti, M. A. & Houghton, P. J. The TOR pathway: a target for cancer therapy. Nature Rev. Cancer 4, 335–348 (2004). · DOI · Paper page
- Gingras, A. C. et al. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 15, 2852–2864 (2001). · DOI · Paper page
- Lal, L. et al. Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood 105, 1669–1677 (2005). · DOI
- Garber, K. Rapamycin's resurrection: a new way to target the cancer cell cycle. J. Natl Cancer Inst. 93, 1517–1519 (2001). · DOI · Paper page
- Ramana, C. V., Gil, P. M., Schreiber, R. D. & Stark, G. R. Stat1-dependent and -independent pathways in IFNγ-dependent signaling. Trends Immunol. 23, 96–101 (2002). · DOI · Paper page
- Sizemore, N. et al. Inhibitor of κB kinase is required to activate a subset of interferon γ-stimulated genes. Proc. Natl Acad. Sci. USA 101, 7994–7998 (2004). · doi:10.1073/pnas.0401593101
- Deane, J. A. & Fruman, D. A. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu. Rev. Immunol. 22, 563–598 (2004). · DOI · Paper page
- Malik, A. H. & Lee, W. M. Chronic hepatitis B virus infection: treatment strategies for the next millennium. Ann. Intern. Med. 132, 723–731 (2000). · DOI
- Liang, T. J., Rehermann, B., Seeff, L. B. & Hoofnagle, J. H. Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann. Intern. Med. 132, 296–305 (2000). · DOI · Paper page
- Loutfy, M. R. et al. Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study. JAMA 290, 3222–3228 (2003). · DOI · Paper page
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Metadata
- Authors
- Platanias, L. C.
- Venue
- Nature Reviews Immunology
- Published
- 2005-05-01
- Volume
- 5
- Issue
- 5
- Pages
- 375-386
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2078844752
- Cited by
- 3,491
- References
- 11
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanisms of type-I- and type-II-interferon-mediated signalling. https://app.cochat.ai/papers/10.1038/nri1604
- The paper
- Platanias, L. C. (2005). Mechanisms of type-I- and type-II-interferon-mediated signalling. Nature Reviews Immunology. https://doi.org/10.1038/nri1604
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.