The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dry Eye as a Mucosal Autoimmune Disease
Open accessAbstract
Dry eye is a common ocular surface inflammatory disease that significantly affects quality of life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular surface homeostasis, facilitating chronic inflammation and tissue damage. Accordingly, the most effective treatments to date are geared towards reducing inflammation and restoring normal tear film. The pathogenic role of CD4+ T cells is well known, and the field is rapidly realizing the complexity of other innate and adaptive immune factors involved in the development and progression of disease. The data support the hypothesis that dry eye is a localized autoimmune disease originating from an imbalance in the protective immunoregulatory and proinflammatory pathways of the ocular surface.
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Citations
Cites
Plasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551 · cited 1×
“IL-12 and IFN-γ influence APC-dependent activation and differentiation of autoreactive Th1 cells [143].”
BackgroundB7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts
Hori, J., Wang, M., Miyashita, M., Tanemoto, K., Takahashi, H., Takemori, T., Okumura, K., Yagita, H., & Azuma, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5928 · Cited by 208
Cited by
Dua, H. S., Said, D. G., Messmer, E. M., Rolando, M., Benitez-del-Castillo, J. M., Hossain, P. N., Shortt, A. J., Geerling, G., Nubile, M., Figueiredo, F. C., et al. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.04.003 · Cited by 404
Dry Eye Management: Targeting the Ocular Surface Microenvironment
Zhang, X., M, V. J., Qu, Y., He, X., Ou, S., Bu, J., Jia, C., Wang, J., Wu, H., Liu, Z., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071398 · Cited by 267
Lifitegrast for the Treatment of Dry Eye Disease
Holland, E. J., Luchs, J., Karpecki, P. M., Nichols, K. K., Jackson, M. A., Sall, K., Tauber, J., Roy, M., Raychaudhuri, A., & Shojaei, A. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2016.09.025 · Cited by 200
Tauber, J., Schechter, B. A., Bacharach, J., Toyos, M. M., Smyth-Medina, R., Weiss, S. L., & Luchs, J. I. (2018) · Clinical ophthalmology · doi:10.2147/opth.s175065 · Cited by 73
Contreras-Ruiz, L., Ryan, D. S., Sia, R. K., Bower, K. S., Dartt, D. A., & Masli, S. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.01.033 · Cited by 58
Metadata
- Authors
- Stern, M. E., Schaumburg, C. S., & Pflugfelder, S. C.
- Venue
- International Reviews of Immunology
- Publisher
- Informa UK Limited
- Published
- 2013-01-13
- Volume
- 32
- Issue
- 1
- Pages
- 19-41
- ISSN
- 0883-0185 (ISSN-L)
- 1563-5244
- OpenAlex
- W2169772679
- Cited by
- 346
- References
- 2
- FWCI
- 26.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stern, M. E., Schaumburg, C. S., & Pflugfelder, S. C. (2013). Dry Eye as a Mucosal Autoimmune Disease. International Reviews of Immunology. https://doi.org/10.3109/08830185.2012.748052
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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