The DOI matches its Crossref record; 92 of the 93 references it cites were found in a registry or an index.
The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism
Abstract
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause mortality, suggesting a fundamental role in biological processes associated with ageing. In cancer, the data available suggest that MIC-1/GDF15 is antitumorigenic, but this may not always be the case as disease progresses. Cancer promoting effects of MIC-1/GDF15 may be due, in part, to effects on antitumour immunity. This is suggested by the anti-inflammatory and immunosuppressive properties of MIC-1/GDF15 in animal models of atherosclerosis and rheumatoid arthritis. Furthermore, in late-stage cancer, large amounts of MIC-1/GDF15 in the circulation suppress appetite and mediate cancer anorexia/cachexia, which can be reversed by monoclonal antibodies in animals. Available data suggest MIC-1/GDF15 may be an important molecule mediating the interplay between cancer, obesity and chronic inflammation.
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In the citing paper
“Additionally, GDF-15 has been reported to be involved in inflammation, metabolism and cancer85”
From Genetic determinants of plasma protein levels in the Estonian population (2024) · cites this paper as [85]
In the citing paper
“Growth differentiation factor 15 (GDF15), also called macrophage inhibitory cytokine-1, is associated with numerous biological processes and diseases including cancer, cardiovascular disease, and obesity [[199], [200], [201], [202]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [200]
Citations
Cites
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The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
McAllister, S. S., & Weinberg, R. A. (2014) · Nature Cell Biology · doi:10.1038/ncb3015 · Cited by 975
Non-Homeostatic Body Weight Regulation Through a Brainstem-Restricted Receptor for GDF15
Hsu, J.-Y., Crawley, S., Chen, M., Ayupova, D. A., Lindhout, D. A., Higbee, J., Kutach, A., Joo, W., Gao, Z., Fu, D., et al. (2017) · Nature · doi:10.1038/nature24042 · Cited by 616
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Spirulina for the Food and Functional Food Industries
Lafarga, T., Fernández-Sevilla, J. M., González-López, C., & Acién-Fernández, F. G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109356 · Cited by 417
Metadata
- Authors
- Breit, S. N., Johnen, H., Cook, A. D., Tsai, V. W. W., Mohammad, M. G., Kuffner, T., Zhang, H. P., Marquis, C. P., Jiang, L., Lockwood, G., Lee-Ng, M., Husaini, Y., Wu, L., Hamilton, J. A., & Brown, D. A.
- Affiliations
- UNSW Sydney (AU)
- The University of Melbourne (AU)
- Corresponding author
- Brown, David A.
- ORCID
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2011-08-11
- Volume
- 29
- Issue
- 5
- Pages
- 187-195
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2126336330
- Cited by
- 247
- References
- 93
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 14 · 2023: 10 · 2022: 14 · 2021: 25 · 2020: 19 · 2019: 19 · 2018: 17 · 2017: 21 · 2016: 27 · 2015: 20 · 2014: 17 · 2013: 12 · 2012: 8
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- TGF-beta superfamily, MIC-1, inflammation, cancer, metabolism, cardiovascular disease, atherosclerosis, rheumatoid arthritis, antitumor immunity, cancer cachexia, appetite suppression, obesity, chronic inflammation, aging, all-cause mortality, monoclonal antibodies
- MeSH terms
- Aging, Animals, Anorexia, Cachexia, Cardiovascular Diseases, Humans, Inflammation, Neoplasms, Biomarkers, Disease Progression, Cell Line, Tumor, Mice, Growth Differentiation Factor 15
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