The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854

Substantial Genetic Influence on Cognitive Abilities in Twins 80 or More Years Old

McClearn, G. E., Johansson, B. E. A., Berg, S., Pedersen, N. L., Ahern, F. M., Petrill, S. A., & Plomin, R. J. (1997) · Science · doi:10.1126/science.276.5318.1560 · Cited by 727

Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Johnen, H., Lin, S., Kuffner, T., Brown, D. A., Tsai, V. W.-W., Bauskin, A. R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1677 · Cited by 612

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

Kempf, T., Zarbock, A., Widera, C., Butz, S., Stadtmann, A., Rossaint, J., Bolomini-Vittori, M., Korf-Klingebiel, M., Napp, L. C., Hansen, B., et al. (2011) · Nature Medicine · doi:10.1038/nm.2354 · Cited by 518

Large-Scale Delineation of Secreted Protein Biomarkers Overexpressed in Cancer Tissue and Serum

Welsh, J. B., Sapinoso, L. M., Kern, S. G., Brown, D. A., Liu, T., Bauskin, A. R., Ward, R. L., Hawkins, N. J., Quinn, D. I., Russell, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530278100 · Cited by 503

Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities

Baek, S. J., Kim, K. S., Nixon, J. B., Wilson, L. C., & Eling, T. E. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.901 · Cited by 402

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

Tanno, T., Porayette, P., Sripichai, O., Noh, S.-J., Byrnes, C., Bhupatiraju, A., Lee, Y. T., Goodnough, J. B., Harandi, O., Ganz, T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195503 · Cited by 352

Macrophage inhibitory cytokine‐1 (MIC‐1/GDF15): a new marker of all‐cause mortality

Wiklund, F. E., Bennet, A. M., Magnusson, P. K. E., Eriksson, U. K., Lindmark, F., Wu, L., Yaghoutyfam, N., Marquis, C. P., Stattin, P. E., Pedersen, N. L., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00629.x · Cited by 293

Circulating Concentrations of Growth-Differentiation Factor 15 in Apparently Healthy Elderly Individuals and Patients with Chronic Heart Failure as Assessed by a New Immunoradiometric Sandwich Assay

Kempf, T., Horn-Wichmann, R., Brabant, G. E., Peter, T., Allhoff, T., Klein, G. G., Drexler, H., Johnston, N., Wallentin, L. C., & Wollert, K. C. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.076828 · Cited by 290

Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

Koopmann, J., Buckhaults, P., Brown, D. A., ZAHURAK, M. L., Sato, N., Fukushima, N., Sokoll, L. J., Chan, D. W., Yeo, C. J., Hruban, R. H., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0165 · Cited by 274

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

McAllister, S. S., & Weinberg, R. A. (2014) · Nature Cell Biology · doi:10.1038/ncb3015 · Cited by 975

Non-Homeostatic Body Weight Regulation Through a Brainstem-Restricted Receptor for GDF15

Hsu, J.-Y., Crawley, S., Chen, M., Ayupova, D. A., Lindhout, D. A., Higbee, J., Kutach, A., Joo, W., Gao, Z., Fu, D., et al. (2017) · Nature · doi:10.1038/nature24042 · Cited by 616

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Cardoso, A. L., Fernandes, A. M. A., Aguilar‐Pimentel, J. A., de Angelis, M. H., Guedes, J. R., Brito, M. A., Ortolano, S., Pani, G., Athanasopoulou, S., Gonos, E. S., et al. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.004 · Cited by 483

Aspirin and colorectal cancer: the promise of precision chemoprevention

Drew, D. A., Cao, Y., & Chan, A. T. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.4 · Cited by 458

Spirulina for the Food and Functional Food Industries

Lafarga, T., Fernández-Sevilla, J. M., González-López, C., & Acién-Fernández, F. G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109356 · Cited by 417

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

Tsai, V. W.-W., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.018 · Cited by 424

The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1

Unsicker, K., Spittau, B., & KRIEGLSTEIN, K. G. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.05.003 · Cited by 279

Inflammation induced loss of skeletal muscle

Londhe, P., & Guttridge, D. C. (2015) · Bone · doi:10.1016/j.bone.2015.03.015 · Cited by 276

Hepatokines and metabolism: Deciphering communication from the liver

Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

Olivieri, F., Spazzafumo, L., Santini, G., Lazzarini, R., Albertini, M. C., Rippo, M. R., Galeazzi, R., Abbatecola, A. M., Marcheselli, F., Monti, D., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.09.004 · Cited by 248

Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

Xiong, Y., Walker, K., Min, X., Hale, C., Tran, T., Komorowski, R., Yang, J., Davda, J., Nuanmanee, N., Kemp, D., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan8732 · Cited by 236

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

Macia, L., Tsai, V. W.-W., Nguyen, A. D., Johnen, H., Kuffner, T., Shi, Y.-C., Lin, S., Herzog, H., Brown, D. A., Breit, S. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034868 · Cited by 211

Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?

Corre, J., Hébraud, B., & Bourin, P. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0055 · Cited by 208

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

Tang, H., Inoki, K., Brooks, S. V., Okazawa, H., Lee, M. C., Wang, J., Kim, M., Kennedy, C. L., Macpherson, P. C. D., Ji, X., et al. (2019) · Aging Cell · doi:10.1111/acel.12943 · Cited by 198

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin

Gerstein, H. C., Pare, G., Hess, S., Ford, R. J., Sjaarda, J., Raman, K., McQueen, M., Lee, S., Haenel, H., & Steinberg, G. R. (2017) · Diabetes Care · doi:10.2337/dc16-1682 · Cited by 169

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

Tiedje, C., Díaz‐Muñoz, M. D., Trulley, P., Ahlfors, H., Laaß, K., Blackshear, P. J., Turner, M., & Gaestel, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw474 · Cited by 166

Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma

Lee, H.-Y., Nga, H. T., Tian, J., & Yi, H. (2021) · Cells · doi:10.3390/cells10081901 · Cited by 152

GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men

Wallentin, L. C., Zethelius, B., Berglund, L., Eggers, K. M., Lind, L., Lindahl, B., Wollert, K. C., & Siegbahn, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078797 · Cited by 132

Regulation of myokine expression: Role of exercise and cellular stress

Ost, M., Coleman, V., Kasch, J., & Klaus, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.018 · Cited by 135

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Bruzzese, F., Hägglöf, C., Leone, A., Sjöberg, E., Roca, M. S., Kiflemariam, S., Sjöblom, T., Hammarsten, P., Egevad, L., Bergh, A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2259 · Cited by 127

Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond

Mullican, S. E., & Rangwala, S. M. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.05.002 · Cited by 127

The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract

Tsai, V. W.-W., Manandhar, R., Jørgensen, S. B., Lee-Ng, K. K. M., Zhang, H. P., Marquis, C. P., Jiang, L., Husaini, Y., Lin, S., Sainsbury, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100370 · Cited by 129

Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

Ost, M., Gil, C. I., Coleman, V., Keipert, S., Efstathiou, S., Vidic, V., Weyers, M., & Klaus, S. (2020) · EMBO Reports · doi:10.15252/embr.201948804 · Cited by 124

Growth Differentiation Factor 15 (GDF-15) in Patients Admitted for Acute Heart Failure: Results from the RELAX-AHF Study

Cotter, G., Voors, A. A., PRESCOTT, M. F., Felker, G. M., Filippatos, G. S., Greenberg, B., Pang, P. S., Ponikowski, P. P., Milo, O., Hua, T. A., et al. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.331 · Cited by 115

Biomarkers of cancer cachexia

Loumaye, A., & Thissen, J. (2017) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2017.07.011 · Cited by 112

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma

Wang, X., Li, Y., Tian, H.-M., Qi, J., Li, M., Fu, C., Wu, F., Wang, Y., Cheng, D., Zhao, W., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-578 · Cited by 111

GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury

Chung, H. K., Kim, J. T., Kim, H.-W., Kwon, M., Kim, S. Y., Shong, M., Kim, K. S., & Yi, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-17574-w · Cited by 111

GDF 15 - A Novel Biomarker in the Offing for Heart Failure

George, M., Jena, A., Srivatsan, V., Rajaram, M., & Dhandapani, V. E. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666160111125304 · Cited by 109

Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15

Tsai, V. W.-W., Lin, S., Brown, D. A., Salis, A., & Breit, S. N. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.242 · Cited by 109

Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline - the Sydney Memory and Aging Study

Fuchs, T. L., Trollor, J. N., Crawford, J., Brown, D. A., Baune, B. T., Samaras, K., Campbell, L. V., Breit, S. N., Brodaty, H., Sachdev, P. S., et al. (2013) · Aging Cell · doi:10.1111/acel.12116 · Cited by 106

Growth differentiation factor 15: A novel biomarker with high clinical potential

Desmedt, S., Desmedt, V., Vos, L. D., Delanghe, J., Speeckaert, R., & Speeckaert, M. M. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1615034 · Cited by 105

Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15

Cimino, I., Kim, H., Tung, Y. C. L., Pedersen, K., Rimmington, D., Tadross, J. A., Kohnke, S., Neves‐Costa, A., Barros, A., Joaquim, S., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106868118 · Cited by 106

Mitochondria, immunosenescence and inflammaging: a role for mitokines?

Conte, M., Martucci, M., Chiariello, A., Franceschi, C., & Salvioli, S. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00813-0 · Cited by 105

Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity

Tsai, V. W.-W., Zhang, H. P., Manandhar, R., Lee-Ng, K. K. M., Lebhar, H., Marquis, C. P., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.258 · Cited by 104

A Prospective Study of Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) and Risk of Colorectal Cancer

Mehta, R. S., Song, M., Bezawada, N., Wu, K., García‐Albéniz, X., Morikawa, T., Fuchs, C. S., Ogino, S., Giovannucci, E. L., & Chan, A. T. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju016 · Cited by 98

Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production

Du, W., Piek, A., Schouten, E. M., van de Kolk, C. W. A., Mueller, C. E., Mebazaa, A., Voors, A. A., de Boer, R. A., & Silljé, H. H. W. (2018) · Theranostics · doi:10.7150/thno.26055 · Cited by 98

Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide

Abulizi, P., Loganathan, N., Zhao, D., Mele, T. S., Zhang, Y., Zwiep, T., Liu, K., & Zheng, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-00902-5 · Cited by 97

Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults

Semba, R. D., Gonzalez-Freire, M., Tanaka, T., Biancotto, A., Zhang, P., Shardell, M., Moaddel, R., CHI Consortium, & Ferrucci, L. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz071 · Cited by 94

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

Tsai, V. W.-W., Macia, L., Feinle‐Bisset, C., Manandhar, R., Astrup, A. V., Raben, A., Lorenzen, J. K., Schmidt, P. T., Wiklund, F. E., Pedersen, N. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133362 · Cited by 96

The Role of Inflammation in Prostate Cancer

Sfanos, K. S., Hempel, H., & Marzo, A. M. D. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-0348-0837-8_7 · Cited by 92

GDF15 is a potential predictive biomarker for TPF induction chemotherapy and promotes tumorigenesis and progression in oral squamous cell carcinoma

Yang, C., Ma, J., Zhu, D., Liu, Y., Montgomery, B. K., Wang, L. Z., Li, J., Zhang, Z. Y., Zhang, C. P., & Zhong, L. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu120 · Cited by 87

Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis

Johnen, H., Kuffner, T., Brown, D. A., Wu, B. J., Stocker, R., & Breit, S. N. (2012) · Cardiovascular Pathology · doi:10.1016/j.carpath.2012.02.003 · Cited by 86

Growth Differentiation Factor 15 in Adverse Cardiac Remodelling: From Biomarker to Causal Player

Wesseling, M., de Poel, J. H. C., & de Jager, S. C. A. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12728 · Cited by 85

Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip

Lind, L., Siegbahn, A., Lindahl, B., Stenemo, M., Sundström, J., & Ärnlöv, J. (2015) · Stroke · doi:10.1161/strokeaha.115.010829 · Cited by 84

Mitochondrial uncoupling and longevity – A role for mitokines?

Klaus, S., & Ost, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110796 · Cited by 80

Anorexia/cachexia of chronic diseases: a role for the TGF‐β family cytokine MIC‐1/GDF15

Tsai, V. W.-W., Husaini, Y., Manandhar, R., Lee-Ng, K. K. M., Zhang, H. P., Harriott, K., Jiang, L., Lin, S., Sainsbury, A., Brown, D. A., et al. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0082-6 · Cited by 86

Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts

Takenouchi, Y., Kitakaze, K., Tsuboi, K., & Okamoto, Y. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112010 · Cited by 80

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

Ost, M., Coleman, V., Voigt, A., van Schothorst, E. M., Keipert, S., van der Stelt, I., Ringel, S., Graja, A., Ambrosi, T., Kipp, A. P., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.11.002 · Cited by 75

Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells

Epple, L. M., Dodd, R. D., Merz, A. L., Dechkovskaia, A. M., Herring, M., Winston, B. A., Lencioni, A., Russell, R. L., Madsen, H. J., Nega, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073267 · Cited by 76

GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer

Ahmed, D. S., Isnard, S., Lin, J. C.-Y., Routy, B., & Routy, J. (2020) · Journal of Cancer · doi:10.7150/jca.50376 · Cited by 71

Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?

Brown, D. A., Hance, K. W., Rogers, C. J., Sansbury, L. B., Albert, P. S., Murphy, G. A., Laiyemo, A. O., Wang, Z., Cross, A. J., Schatzkin, A. G., et al. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0786 · Cited by 64

Overview of growth differentiation factor 15 (GDF15) in metabolic diseases

Li, J., Hu, X., Xie, Z., Li, J., Huang, C. L., & Huang, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116809 · Cited by 72

Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure

Vegter, E. L., Schmitter, D., Hagemeijer, Y. P., Ovchinnikova, E. S., van der Harst, P., Teerlink, J. R., O’Connor, C. M., Metra, M., Davison, B. A., Bloomfield, D. M., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.09.010 · Cited by 60

Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD

Husebø, G. R., Grønseth, R., Lerner, L., Gyuris, J., Hardie, J. A., Bakke, P. S., & Eagan, T. M. (2017) · European Respiratory Journal · doi:10.1183/13993003.01298-2016 · Cited by 58

Iron Status and Inflammation in Early Stages of Chronic Kidney Disease

Łukaszyk, E., Łukaszyk, M., Koc‐Żórawska, E., Tobolczyk, J., Bodzenta­‐Łukaszyk, A., & Małyszko, J. (2015) · Kidney & Blood Pressure Research · doi:10.1159/000368512 · Cited by 58

Growth/differentiation factor-15 deficiency compromises dopaminergic neuron survival and microglial response in the 6-hydroxydopamine mouse model of Parkinson's disease

Machado, V., Haas, S. J.-P., Halbach, O. V. B. U., Wree, A., KRIEGLSTEIN, K. G., Unsicker, K., & Spittau, B. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.12.016 · Cited by 56

Growth Differentiation Factor 15 (GDF-15) Plasma Levels Increase during Bleomycin- and Cisplatin-Based Treatment of Testicular Cancer Patients and Relate to Endothelial Damage

Altena, R., Fehrmann, R. S. N., Boer, H., de Vries, E. G. E., Meijer, C., & Gietema, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115372 · Cited by 56

Multimarker Analysis of Serially Measured GDF-15, NT-proBNP, ST2, GAL-3, cTnI, Creatinine, and Prognosis in Acute Heart Failure

Gürgöze, M. T., van Vark, L. C., Baart, S. J., Kardys, I., Akkerhuis, K. M., Manintveld, O. C., Postmus, D., Hillege, H. L., Lesman‐Leegte, I., Asselbergs, F. W., et al. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.122.009526 · Cited by 58

Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality

Mehta, R. S., Chong, D. Q., Song, M., Meyerhardt, J. A., Ng, K., Nishihara, R., Qian, Z., Morikawa, T., Wu, K., Giovannucci, E. L., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.038 · Cited by 54

Growth differentiation factor 15 as a potential therapeutic for treating obesity

Hale, C., & Véniant, M. M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101117 · Cited by 54

Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression

Kalli, M., Voutouri, C., Minia, A., Pliaka, V., Fotis, C., Alexopoulos, L. G., & Stylianopoulos, T. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00992 · Cited by 55

Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells

Zhai, Y., Zhang, J., Wang, H., Lu, W., Liu, S., Yu, Y., Weng, W., Ding, Z., Zhu, Q., & Shi, J. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0405-0 · Cited by 51

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Hao, S., Xiang, J., Wu, D.-C., Fraser, J. W., Ruan, B., Cai, J., Patterson, A. D., Lai, Z.-C., & Paulson, R. F. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000375 · Cited by 52

Growth differentiation factor 15 (GDF15) in cancer cell metastasis: from the cells to the patients

Spanopoulou, A., & Gkretsi, V. (2020) · Clinical & Experimental Metastasis · doi:10.1007/s10585-020-10041-3 · Cited by 50

Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1

Darwich, A., Silvestri, A., Benmebarek, M.-R., Mouriès, J., Cadilha, B. L., Melacarne, A., Morelli, L., Supino, D., Taleb, A., Obeck, H., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003224 · Cited by 50

Inhibitory Effects of Salinomycin on Cell Survival, Colony Growth, Migration, and Invasion of Human Non-Small Cell Lung Cancer A549 and LNM35: Involvement of NAG-1

Arafat, K., Iratni, R., Takahashi, T., Parekh, K. A., Dhaheri, Y. A., Adrian, T. E., & Attoub, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066931 · Cited by 49

Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15

Borner, T., Arnold, M., Ruud, J., Breit, S. N., Langhans, W., Lutz, T. A., Blomqvist, A. G., & Riediger, T. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12169 · Cited by 50

Growth differentiation factor 15 promotes blood vessel growth by stimulating cell cycle progression in repair of critical-sized calvarial defect

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Exploratory studies of the potential anti-cancer effects of creatine

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Association of Growth Differentiation Factor 15 with Mortality in a Prospective Hemodialysis Cohort

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Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells

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Twist promotes invasion and cisplatin resistance in pancreatic cancer cells through growth differentiation factor 15

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Increased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis

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Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation

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Associations Between Serum GDF15 Concentrations, Muscle Mass, and Strength Show Sex-Specific Differences in Older Hospital Patients

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