Cited by 247GDF15 and Related BiomarkersTGF-β signaling in diseasesCardiac Fibrosis and Remodeling

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The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

Breit, Samuel N., Johnen, Heiko, Cook, Andrew D., Tsai, Vicky W. W., Mohammad, Mohammad G., Kuffner, Tamara, Zhang, Hong Ping, Marquis, Christopher P., Jiang, Lele, Lockwood, Glen, Lee-Ng, Michelle, Husaini, Yasmin, Wu, Liyun, Hamilton, John A., Brown, David A.·2011·Growth Factors

DOI 10.3109/08977194.2011.607137

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Abstract

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause mortality, suggesting a fundamental role in biological processes associated with ageing. In cancer, the data available suggest that MIC-1/GDF15 is antitumorigenic, but this may not always be the case as disease progresses. Cancer promoting effects of MIC-1/GDF15 may be due, in part, to effects on antitumour immunity. This is suggested by the anti-inflammatory and immunosuppressive properties of MIC-1/GDF15 in animal models of atherosclerosis and rheumatoid arthritis. Furthermore, in late-stage cancer, large amounts of MIC-1/GDF15 in the circulation suppress appetite and mediate cancer anorexia/cachexia, which can be reversed by monoclonal antibodies in animals. Available data suggest MIC-1/GDF15 may be an important molecule mediating the interplay between cancer, obesity and chronic inflammation.

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See all 247

Authors: Breit, S. N., Johnen, H., Cook, A. D., Tsai, V. W. W., Mohammad, M. G., Kuffner, T., Zhang, H. P., Marquis, C. P., Jiang, L., Lockwood, G., Lee-Ng, M., Husaini, Y., Wu, L., Hamilton, J. A., & Brown, D. A.
Affiliations: UNSW Sydney (AU)
The University of Melbourne (AU)
Corresponding author: Brown, David A.
ORCID: Breit, Samuel N.
Cook, Andrew D.
Tsai, Vicky W. W.
Mohammad, Mohammad G.
Zhang, Hong Ping
Marquis, Christopher P.
Jiang, Lele
Lockwood, Glen
Wu, Liyun
Hamilton, John A.
Brown, David A.
Venue: Growth Factors
Publisher: Informa UK Limited
Published: 2011-08-11
Volume: 29
Issue: 5
Pages: 187-195
ISSN: 0897-7194 (ISSN-L)
1029-2292
DOI: 10.3109/08977194.2011.607137
OpenAlex: W2126336330
Cited by: 247
References: 93
Citations by year: 2026: 9 · 2025: 15 · 2024: 14 · 2023: 10 · 2022: 14 · 2021: 25 · 2020: 19 · 2019: 19 · 2018: 17 · 2017: 21 · 2016: 27 · 2015: 20 · 2014: 17 · 2013: 12 · 2012: 8
FWCI: 8.50
Type: journal article
Language: en
Open access: closed
Locations: Growth Factors (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: TGF-beta superfamily, MIC-1, inflammation, cancer, metabolism, cardiovascular disease, atherosclerosis, rheumatoid arthritis, antitumor immunity, cancer cachexia, appetite suppression, obesity, chronic inflammation, aging, all-cause mortality, monoclonal antibodies
MeSH terms: Aging, Animals, Anorexia, Cachexia, Cardiovascular Diseases, Humans, Inflammation, Neoplasms, Biomarkers, Disease Progression, Cell Line, Tumor, Mice, Growth Differentiation Factor 15

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The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

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