The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Differential Endothelial Migration and Proliferation to Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor
Abstract
Neovascularization is a feature of a variety of pathological processes. We compared the characteristics of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) on migration and proliferation of human umbilical vein endothelium (HUVEC). Both VEGF and bFGF induced endothelial cell migration at similar concentrations (1/2 max. VEGF = approximately 1.0 ng/ml, bFGF = approximately 5.0 ng/ml). However, VEGF-stimulated migration was two-fold greater than bFGF at 1 and 10 ng/ml (p < 0.05). In contrast, bFGF induced proliferation four-fold more effectively than VEGF (1/2 max. 1 ng/ml and 1.4 ng/ml respectively). Checkerboard migration assays for bFGF showed a predominantly chemokinetic pattern, whereas VEGF was predominantly chemotactic. VEGF and bFGF were not synergistic in monolayer proliferation and migration assays. Three angiogenesis inhibitors, alpha-interferon, TNP-470, and platelet factor-4, inhibited VEGF and bFGF induced cell migration. These results indicate that VEGF and bFGF are chemoattractants that stimulate endothelial migration by different mechanisms and that both can be inhibited by known angiogenesis inhibitors.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
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Angiogenesis: regulators and clinical applications
Liekens, S., De Clercq, E., & Neyts, J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00529-3 · Cited by 748
Zieris, A., Prokoph, S., Levental, K. R., Welzel, P. B., Grimmer, M., Freudenberg, U., & Werner, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.021 · Cited by 209
Belair, D. G., Whisler, J. A., Valdez, J., Velazquez, J., Molenda, J. A., Vickerman, V., Lewis, R., Daigh, C., Hansen, T. D., Mann, D. A., et al. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9549-5 · Cited by 120
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Becker, C. M., Beaudry, P., Funakoshi, T., Benny, O., Zaslavsky, A., Zurakowski, D., Folkman, J., D'Amato, R. J., & Ryeom, S. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.12.037 · Cited by 81
Metadata
- Authors
- Yoshida, A., Anand-apte, B., & Zetter, B. R.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 13
- Issue
- 1-2
- Pages
- 57-64
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2105239075
- Cited by
- 252
- References
- 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yoshida, A., Anand-apte, B., & Zetter, B. R. (1996). Differential Endothelial Migration and Proliferation to Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor. Growth Factors. https://doi.org/10.3109/08977199609034566
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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