Review of Ocular Immune Privilege in the Year 2010: Modifying the Immune Privilege of the Eye
Abstract
The original evidence for the existence of immunologically privileged sites in the body was based on the prolonged survival of genetically disparate transplanted tissue in the anterior chamber of the eye. The failure of the immune system to elicit an immune response in this and other such sites constitutes the hallmark of the immune privilege status. The remarkably successful field of corneal transplantation in clinical practice is undoubtedly associated with corneal immune privilege. Several investigations have addressed the regulatory mechanisms governing this phenomenon, which involves a complex interplay between multiple molecular and cellular pathways. Furthermore, the use of various transgenic mouse models has facilitated the identification of critical pathways, which upon disruption can modify the immune privileged status of the eye. Understanding these pathways not only reveals the mechanisms underlying various ocular inflammatory disease conditions, but also has clinical implications for the transplantation field and for the treatment of autoimmunity.
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The blood-retina barrier acts as a physical and immune bulwark, blocking entry of circulating immune cells inside the retina and preventing antigens from escaping the retina.
“The blood-retina barrier, which is partly composed by tight junctions (depicted in yellow) between RPE cells, acts as a physical and immune bulwark.It blocks the entry of circulating immune cells inside the retina and prevents antigens from escaping the retina [14][15][16].”
From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [15]
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- Authors
- Hori, J., Vega, J. L., & Masli, S.
- Affiliations
- Nippon Medical School (JP)
- Harvard University (US)
- Corresponding author
- Masli, Sharmila
- Venue
- Ocular Immunology and Inflammation
- Publisher
- Informa UK Limited
- Published
- 2010-09-17
- Volume
- 18
- Issue
- 5
- Pages
- 325-333
- ISSN
- 0927-3948 (ISSN-L)
- 1744-5078
- OpenAlex
- W2134245703
- Cited by
- 64
- References
- 93
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 8
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ocular Immunology and Inflammation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23592619)
- National Eye Institute (R01EY015472)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Keywords
- ocular immune privilege, immune privilege, corneal transplantation, transgenic mouse model, ocular inflammatory diseases, autoimmunity, transplantation tolerance, regulatory mechanisms
- MeSH terms
- Afferent Pathways, Animals, Anterior Chamber, Cornea, Eye, Graft Survival, Humans, Immune System, Immune Tolerance, Immunologic Factors, Nerve Fibers, Ophthalmologic Surgical Procedures, Genetic Therapy, Corneal Transplantation, Tissue Transplantation, Cell Transplantation, T-Lymphocytes, Regulatory
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