Cited by 54Connective Tissue Growth Factor ResearchTGF-β signaling in diseasesBone and Dental Protein Studies

Matricellular protein thrombospondins: influence on ocular angiogenesis, wound healing and immuneregulation

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Masli, Sharmila, Sheibani, Nader, Cursiefen, Claus, Zieske, James·2014·Current Eye Research

Abstract

Thrombospondins are a family of large multi-domain glycoproteins described as matricelluar proteins based on their ability to interact with a broad range of receptors, matrix molecules, growth factors or proteases, and to modulate array of cellular functions including intracellular signaling, proliferation and migration. Two members of the thrombospondin family, thrombospondin 1 (TSP-1) and thrombospondin 2 (TSP-2) are studied extensively to determine their structure and function. While expressed at low levels in normal adult tissues, their increased expression is seen predominantly in response to cellular perturbations. Despite structural similarities, a notable functional difference between TSP-1 and TSP-2 includes the ability of former to activate of latent TGF-β and its competitive inhibition by the latter. Both these thrombospondins are reported to play important roles in TGF-β rich ocular environment with most reports related to TSP-1. They are expressed by many ocular cell types and detectable in the aqueous and vitreous humor. TSP-1 and TSP-2 influence many cellular interactions in the eye such as angiogenesis, cell migration, wound healing, TGF-β activation and regulation of inflammatory immune responses. Together, these processes are known to contribute to the immune privilege status of the eye. Emerging roles of TSP-1 and TSP-2 in ocular functions and pathology are reviewed here.

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Authors
Masli, S., Sheibani, N., Cursiefen, C., & Zieske, J.
Affiliations
  • Boston University (US)
  • University of Wisconsin–Madison (US)
  • University of Cologne (DE)
  • Massachusetts Eye and Ear Infirmary (US)
Corresponding author
Masli, Sharmila
Venue
Current Eye Research
Published
2014-02-21
Volume
39
Issue
8
Pages
759-774
ISSN
  • 0271-3683 (ISSN-L)
  • 1460-2202
OpenAlex
W2157167110
Cited by
54
References
113
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 2 · 2015: 7
FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Current Eye Research (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (1rc4ey021357-01)
  • National Eye Institute (RC4-EY021357, R24EY022883, P30EY016665, P30EY003790)
  • National Cancer Institute (P30CA014520)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords
thrombospondin-1, thrombospondin-2, matricellular proteins, ocular angiogenesis, wound healing, immune regulation, TGF-beta activation, TGF-beta inhibition, immune privilege, ocular inflammation, cell migration, aqueous humor, vitreous humor
MeSH terms
Animals, Eye, Eye Diseases, Humans, Immunity, Cellular, Neovascularization, Pathologic, Wound Healing, Signal Transduction, Thrombospondins

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