The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Platelets in inflammation and infection
Abstract
Although platelets are traditionally recognized for their central role in hemostasis, many lines of research clearly demonstrate these rather ubiquitous blood components are potent immune modulators and effectors. Platelets have been shown to directly recognize, sequester and kill pathogens, to activated and recruit leukocytes to sites of infection and inflammation, and to modulate leukocyte behavior, enhancing their ability to phagocytose and kill pathogens and inducing unique effector functions, such as the production of Neutrophil Extracellular Traps (NETs). This multifaceted response to infection and inflammation is due, in part, to the huge array of soluble mediators and cell surface molecules expressed by platelets. From their earliest origins as primordial hemocytes in invertebrates to their current form as megakaryocyte-derived cytoplasts, platelets have evolved to be one of the key regulators of host intravascular immunity and inflammation. In this review, we present the diverse roles platelets play in immunity and inflammation associated with autoimmune diseases and infection. Additionally, we highlight recent advances in our understanding of platelet behavior made possible through the use of advanced imaging techniques that allow us to visualize platelets and their interactions, in real-time, within the intact blood vessels of a living host.
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Cites
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
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Self-citationCD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
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Platelets and the immune continuum
Semple, J. W., Italiano, J. E., & Freedman, J. (2011) · Nature Reviews Immunology · doi:10.1038/nri2956 · Cited by 1,692
Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada
Kumar, A. (2009) · JAMA · doi:10.1001/jama.2009.1496 · Cited by 1,425
Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
Boilard, E., Nigrovic, P. A., Larabee, K., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold-O’Donnell, E., Farndale, R. W., Ware, J., et al. (2010) · Science · doi:10.1126/science.1181928 · Cited by 1,085
Cell-mediated immunity in arthropods: Hematopoiesis, coagulation, melanization and opsonization
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Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis
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Self-citationRecent Advances in the Innate Immunity of Invertebrate Animals
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Cited by
Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with coronavirus disease‐19
Qu, R., Ling, Y., Zhang, Y., Wei, L., Chen, X., Li, X., Liu, X., Liu, H., Guo, Z., Ren, H., et al. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25767 · Cited by 580
Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver
McDonald, B., & Kubes, P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.048 · Cited by 123
Self-citationImmune Sensing of Candida albicans
Bojang, E., Ghuman, H., Kumwenda, P., & Hall, R. A. (2021) · Journal of Fungi · doi:10.3390/jof7020119 · Cited by 96
Metadata
- Authors
- Jenne, C. N., & Kubes, P.
- Venue
- Platelets
- Publisher
- Informa UK Limited
- Published
- 2015-03-25
- Volume
- 26
- Issue
- 4
- Pages
- 286-292
- ISSN
- 0953-7104 (ISSN-L)
- 1369-1635
- OpenAlex
- W2004382335
- Cited by
- 271
- References
- 56
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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