Cited by 88Phytochemicals and Antioxidant ActivitiesPhytochemistry and Biological ActivitiesMedicinal Plant Research

Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon thyme, mint, oregano, rosemary, sage, and thyme

Park, Jae B.·2011·International Journal of Food Sciences and Nutrition

Abstract

Major phenolic compounds from basil, lemon thyme, mint, oregano, rosemary, sage, and thyme were investigated using a high-performance liquid chromatography (HPLC) profiling technique in combination with DPPH-radical scavenging, xanthine oxidase and cyclooxygenase assays. For the present study, 15 plant-derived phenolic compounds (gallic, protocatechuic, vanillic, syringic, chlorogenic, rosmarinic, caffeic, ferulic, and sinapic acids, protocatechualdehyde, vanillin, N-coumaroyltyramine, N-caffeoyltyramine, N-feruloyltyramine, and N-sinapoyltyramine) were selected and their DPPH-radical scavenging activities were first determined. Then, a standard HPLC profiling of these phenolics was constructed using an HPLC method to isolate anti-oxidant and anti-inflammatory phenolic compounds from MeOH extracts of the plants. Rosmarinic acid was identified as a major anti-oxidant compound (0.22-0.97%) in all seven herbs, confirmed by nuclear magnetic resonance. Rosmarinic acid from the plants quenched superoxide radicals from xanthine oxidase and inhibited cyclooxygenase I and II enzymes. In this study, the rosmarinic acid content of perilla was also determined and compared with those of the seven herbs.

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Crossref · 10.3109/09637486.2011.562882

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Authors
Park, J. B.
Affiliations
Agricultural Research Service (US)
Corresponding author
Park, Jae B.
Venue
International Journal of Food Sciences and Nutrition
Published
2011-04-21
Volume
62
Issue
6
Pages
577-584
ISSN
  • 0963-7486 (ISSN-L)
  • 1465-3478
OpenAlex
W2130299897
Cited by
88
References
35
Citations by year
2026: 4 · 2025: 5 · 2024: 3 · 2023: 13 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 4
FWCI
3.55
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Food Sciences and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
rosmarinic acid, phenolic compounds, antioxidant activity, anti-inflammatory activity, DPPH radical scavenging, xanthine oxidase inhibition, cyclooxygenase inhibition, Ocimum basilicum, lemon thyme, Mentha, oregano, Rosmarinus officinalis, sage, thyme, Perilla frutescens, HPLC profiling
MeSH terms
Antioxidants, Biphenyl Compounds, Phenols, Picrates, Plant Extracts, Superoxides, Xanthine Oxidase, Cyclooxygenase Inhibitors, Lamiaceae

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