Cited by 28Edible Oils Quality and AnalysisFatty Acid Research and HealthAntioxidant Activity and Oxidative Stress

Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products

Katsarou, Ageliki I., Kaliora, Andriana C., Papalois, Apostolos, Chiou, Antonia, Kalogeropoulos, Nick, Agrogiannis, George, Andrikopoulos, Nikolaos K.·2015·International Journal of Food Sciences and Nutrition

Abstract

Extra virgin olive oil (EVOO) major and minor component anti-inflammatory effect on aorta was evaluated; Wistar rats were fed (9 weeks) on either a high-cholesterol diet (HCD) or a HCD supplemented with oils, i.e. EVOO, sunflower oil (SO), high-oleic sunflower oil (HOSO), or oil-products modified to their phenolic content, i.e. phenolics deprived-EVOO [EVOO(-)], SO enriched with the EVOO phenolics [SO(+)], HOSO enriched with the EVOO phenolics [HOSO(+)]. HCD induced dyslipidemia and resulted in higher aorta adhesion molecules levels at euthanasia. Groups receiving EVOO, EVOO(-), HOSO, HOSO(+) presented higher serum TC and LDL-c levels compared to cholesterol-fed rats; attenuation of aorta E-selectin levels was also observed. In EVOO/EVOO(-) groups, aorta vascular endothelial adhesion molecule-1 (VCAM-1) was lower compared to HCD animals. SO/SO(+) diets had no effect on endothelial dysfunction amelioration. Overall, our results suggest that major and/or minor EVOO constituents improve aorta E-selectin and VCAM-1, while serum lipids do not benefit.

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Crossref · 10.3109/09637486.2015.1088936

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  • An animal experiment using high-fat diets supplemented with EVOO, HOSO and SO showed that TC and LDL-C increased, and HDL-C decreased in comparison with control animals, suggesting no effect of the phenolic fraction nor the MUFA-rich content of EVOO and HOSO.

    “This was in accordance with results from an animal experiment using high-fat diets supplemented with EVOO, HOSO and SO, showing that TC and LDL-C increased, and HDL-C decreased in comparison with control animals, suggesting no effect of the phenolic fraction nor the MUFA-rich content of EVOO and HOSO [33].”

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Authors
Katsarou, A. I., Kaliora, A. C., Papalois, A., Chiou, A., Kalogeropoulos, N., Agrogiannis, G., & Andrikopoulos, N. K.
Affiliations
  • Harokopio University of Athens (GR)
  • Elpen Pharmaceutical (Greece) (GR)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
Chiou, Antonia
Venue
International Journal of Food Sciences and Nutrition
Published
2015-09-24
Volume
66
Issue
7
Pages
766-773
ISSN
  • 0963-7486 (ISSN-L)
  • 1465-3478
OpenAlex
W1934885232
Cited by
28
References
51
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2017: 2
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Food Sciences and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • European Commission
  • European Social Fund
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
extra virgin olive oil, sunflower oil, high oleic sunflower oil, high-cholesterol diet, aorta, lipid profile, inflammatory markers, E-selectin, VCAM-1, endothelial dysfunction, phenolic compounds, dyslipidemia, LDL cholesterol, atherosclerosis
MeSH terms
Olive Oil, Sunflower Oil, Animals, Anti-Inflammatory Agents, Aorta, Cholesterol, Dietary, Endothelium, Vascular, Helianthus, Hypercholesterolemia, Inflammation, Cholesterol, LDL, Male, Phytotherapy, Phenols, Plant Extracts, Plant Oils, Biomarkers, Rats, Wistar, Vascular Cell Adhesion Molecule-1, E-Selectin, Oleic Acid, Dietary Supplements, Olea, Atherosclerosis, Diet, High-Fat

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