Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products
Abstract
Extra virgin olive oil (EVOO) major and minor component anti-inflammatory effect on aorta was evaluated; Wistar rats were fed (9 weeks) on either a high-cholesterol diet (HCD) or a HCD supplemented with oils, i.e. EVOO, sunflower oil (SO), high-oleic sunflower oil (HOSO), or oil-products modified to their phenolic content, i.e. phenolics deprived-EVOO [EVOO(-)], SO enriched with the EVOO phenolics [SO(+)], HOSO enriched with the EVOO phenolics [HOSO(+)]. HCD induced dyslipidemia and resulted in higher aorta adhesion molecules levels at euthanasia. Groups receiving EVOO, EVOO(-), HOSO, HOSO(+) presented higher serum TC and LDL-c levels compared to cholesterol-fed rats; attenuation of aorta E-selectin levels was also observed. In EVOO/EVOO(-) groups, aorta vascular endothelial adhesion molecule-1 (VCAM-1) was lower compared to HCD animals. SO/SO(+) diets had no effect on endothelial dysfunction amelioration. Overall, our results suggest that major and/or minor EVOO constituents improve aorta E-selectin and VCAM-1, while serum lipids do not benefit.
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An animal experiment using high-fat diets supplemented with EVOO, HOSO and SO showed that TC and LDL-C increased, and HDL-C decreased in comparison with control animals, suggesting no effect of the phenolic fraction nor the MUFA-rich content of EVOO and HOSO.
“This was in accordance with results from an animal experiment using high-fat diets supplemented with EVOO, HOSO and SO, showing that TC and LDL-C increased, and HDL-C decreased in comparison with control animals, suggesting no effect of the phenolic fraction nor the MUFA-rich content of EVOO and HOSO [33].”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [33]
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“This was in accordance with results from an animal experiment using high-fat diets supplemented with EVOO, HOSO and SO, showing that TC and LDL-C increased, and HDL-C decreased in comparison with control animals, suggesting no effect of the phenolic fraction nor the MUFA-rich content of EVOO and HOSO [33].”
Result
- Authors
- Katsarou, A. I., Kaliora, A. C., Papalois, A., Chiou, A., Kalogeropoulos, N., Agrogiannis, G., & Andrikopoulos, N. K.
- Affiliations
- Harokopio University of Athens (GR)
- Elpen Pharmaceutical (Greece) (GR)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Chiou, Antonia
- ORCID
- Venue
- International Journal of Food Sciences and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-09-24
- Volume
- 66
- Issue
- 7
- Pages
- 766-773
- ISSN
- 0963-7486 (ISSN-L)
- 1465-3478
- OpenAlex
- W1934885232
- Cited by
- 28
- References
- 51
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2017: 2
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Sciences and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- European Social Fund
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- extra virgin olive oil, sunflower oil, high oleic sunflower oil, high-cholesterol diet, aorta, lipid profile, inflammatory markers, E-selectin, VCAM-1, endothelial dysfunction, phenolic compounds, dyslipidemia, LDL cholesterol, atherosclerosis
- MeSH terms
- Olive Oil, Sunflower Oil, Animals, Anti-Inflammatory Agents, Aorta, Cholesterol, Dietary, Endothelium, Vascular, Helianthus, Hypercholesterolemia, Inflammation, Cholesterol, LDL, Male, Phytotherapy, Phenols, Plant Extracts, Plant Oils, Biomarkers, Rats, Wistar, Vascular Cell Adhesion Molecule-1, E-Selectin, Oleic Acid, Dietary Supplements, Olea, Atherosclerosis, Diet, High-Fat
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