Cellular toxicity of lipophilic compounds: Mechanisms, implications, and adaptations

Sikkema, Jan; Weber, Frans J.; Heipieper, Hermann J.; Bont, Jan A. M. De

doi:10.3109/10242429409065221

Cited by 71Bioactive Compounds and Antitumor AgentsEnvironmental Toxicology and EcotoxicologyDrug-Induced Hepatotoxicity and Protection

Cellular toxicity of lipophilic compounds: Mechanisms, implications, and adaptations

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Sikkema, Jan, Weber, Frans J., Heipieper, Hermann J., Bont, Jan A. M. De·1994·Biocatalysis

DOI 10.3109/10242429409065221

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Cyclic monoterpenes preferentially partition from an aqueous phase into membrane structures due to their lipophilic character.
“Sikkema et al. [26,114] showed that as a result of their lipophilic character, cyclic monoterpenes are preferentially reparted from an aqueous phase into membrane structures.”
From Effect of essential oils on pathogenic bacteria (2013) · cites this paper as [114]

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“In technical applications of microorganisms in the presence of lipophilic compounds, the accumulation of such molecules can be prevented by either selecting resistant strains or changing the conditions (273, 277).”
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“[59, 60] showed that as a result of lipophilic character of monoterpenoid components they are preferentially partitioned from an aqueous phase into membrane structures.”
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Lipophilic compounds in biotechnology—interactions with cells and technological problems1Dedicated to Professor Dr Wolfgang Fritsche on the occasion of his 65th birthday.12Based on the symposium, `Interactions between cells and lipophilic substances' held at the 8th European Congress on Biotechnology (ECB8) in Budapest, Hungary, August 1997.2
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Authors: Sikkema, J., Weber, F. J., Heipieper, H. J., & Bont, J. A. M. D.
Affiliations: Wageningen University & Research (NL)
ORCID: Heipieper, Hermann J.
Venue: Biocatalysis
Publisher: Informa UK Limited
Published: 1994-01
Volume: 10
Issue: 1-4
Pages: 113-122
ISSN: 0886-4454 (ISSN-L)
DOI: 10.3109/10242429409065221
OpenAlex: W2005169232
Cited by: 71
References: 46
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 1
FWCI: 5.77
Type: journal article
Language: en
Open access: green
research.wur.nl
Locations: Biocatalysis (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords: lipophilic compounds, cytotoxicity, toxicity mechanisms, cellular adaptation

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