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Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study
Open accessAbstract
Although stressful life events (SLEs) have been associated with an increased risk of illness and mental disorder, their impact on brain anatomy remains poorly understood. Using a longitudinal design, we tested the hypothesis that SLEs are significantly associated with changes in gray matter volume (GMV) in brain regions previously implicated in post-traumatic stress disorder (PTSD) in a group of clinically healthy adults. Magnetic resonance imaging was used to acquire an anatomical scan from 26 subjects (13 males and 13 females; mean age ± SD: 25.2 ± 4.3 years), with no psychiatric diagnosis, at two time points with a 3-month interval. Voxel-based morphometry was used to examine an association between SLEs and gray matter changes during this period. The number of SLEs was associated with a decrease in GMV in the anterior cingulate, hippocampus, and parahippocampal gyrus (p < 0.001). In contrast, there were no areas where the number of SLEs was associated with an increase in GMV. These results provide evidence that, in adults with no formal psychiatric diagnosis, SLEs are associated with GMV decreases in a subset of regions implicated in PTSD, and that these alterations can be observed within a period as short as 3 months.
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“greater baseline life stress was associated with the development of smaller hippocampal volumes three months later in a sample of HCs (48).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [48]
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Metadata
- Authors
- Papagni, S. A., Benetti, S., Arulanantham, S., McCrory, E., McGuire, P., & Mechelli, A.
- Affiliations
- King's College London (GB)
- University College London (GB)
- Corresponding author
- Mechelli, Andrea
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2010-10-31
- Volume
- 14
- Issue
- 2
- Pages
- 227-232
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W1745608382
- Cited by
- 126
- References
- 20
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 12 · 2012: 6
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Royal Society
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- life events, gray matter volume, brain structure, post-traumatic stress disorder, anterior cingulate cortex, hippocampus, parahippocampal gyrus, longitudinal change, healthy adults
- MeSH terms
- Adult, Brain, Female, Gyrus Cinguli, Hippocampus, Humans, Life Change Events, Longitudinal Studies, Magnetic Resonance Imaging, Male, Stress Disorders, Post-Traumatic, Prefrontal Cortex
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