Cited by 128Posttraumatic Stress Disorder ResearchStress Responses and CortisolChild Abuse and Trauma

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Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study

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Papagni, Sergio Alessandro, Benetti, Stefania, Arulanantham, Sobida, McCrory, Eamon, McGuire, Philip, Mechelli, Andrea·2011·Stress

DOI 10.3109/10253890.2010.522279

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Abstract

Although stressful life events (SLEs) have been associated with an increased risk of illness and mental disorder, their impact on brain anatomy remains poorly understood. Using a longitudinal design, we tested the hypothesis that SLEs are significantly associated with changes in gray matter volume (GMV) in brain regions previously implicated in post-traumatic stress disorder (PTSD) in a group of clinically healthy adults. Magnetic resonance imaging was used to acquire an anatomical scan from 26 subjects (13 males and 13 females; mean age ± SD: 25.2 ± 4.3 years), with no psychiatric diagnosis, at two time points with a 3-month interval. Voxel-based morphometry was used to examine an association between SLEs and gray matter changes during this period. The number of SLEs was associated with a decrease in GMV in the anterior cingulate, hippocampus, and parahippocampal gyrus (p < 0.001). In contrast, there were no areas where the number of SLEs was associated with an increase in GMV. These results provide evidence that, in adults with no formal psychiatric diagnosis, SLEs are associated with GMV decreases in a subset of regions implicated in PTSD, and that these alterations can be observed within a period as short as 3 months.

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Authors: Papagni, S. A., Benetti, S., Arulanantham, S., McCrory, E., McGuire, P., & Mechelli, A.
Affiliations: King's College London (GB)
University College London (GB)
Corresponding author: Mechelli, Andrea
ORCID: Benetti, Stefania
McCrory, Eamon
McGuire, Philip
Mechelli, Andrea
Venue: Stress
Publisher: Informa UK Limited
Published: 2010-10-31
Volume: 14
Issue: 2
Pages: 227-232
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.3109/10253890.2010.522279
OpenAlex: W1745608382
Cited by: 126
References: 20
Citations by year: 2026: 5 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 12 · 2012: 6
FWCI: 6.69
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stress (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Royal Society
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: life events, gray matter volume, brain structure, post-traumatic stress disorder, anterior cingulate cortex, hippocampus, parahippocampal gyrus, longitudinal change, healthy adults
MeSH terms: Adult, Brain, Female, Gyrus Cinguli, Hippocampus, Humans, Life Change Events, Longitudinal Studies, Magnetic Resonance Imaging, Male, Stress Disorders, Post-Traumatic, Prefrontal Cortex

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Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study

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