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Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study
Open accessAbstract
Although stressful life events (SLEs) have been associated with an increased risk of illness and mental disorder, their impact on brain anatomy remains poorly understood. Using a longitudinal design, we tested the hypothesis that SLEs are significantly associated with changes in gray matter volume (GMV) in brain regions previously implicated in post-traumatic stress disorder (PTSD) in a group of clinically healthy adults. Magnetic resonance imaging was used to acquire an anatomical scan from 26 subjects (13 males and 13 females; mean age ± SD: 25.2 ± 4.3 years), with no psychiatric diagnosis, at two time points with a 3-month interval. Voxel-based morphometry was used to examine an association between SLEs and gray matter changes during this period. The number of SLEs was associated with a decrease in GMV in the anterior cingulate, hippocampus, and parahippocampal gyrus (p < 0.001). In contrast, there were no areas where the number of SLEs was associated with an increase in GMV. These results provide evidence that, in adults with no formal psychiatric diagnosis, SLEs are associated with GMV decreases in a subset of regions implicated in PTSD, and that these alterations can be observed within a period as short as 3 months.
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“greater baseline life stress was associated with the development of smaller hippocampal volumes three months later in a sample of HCs (48).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [48]
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A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Park, C. L. (2010) · Psychological Bulletin · doi:10.1037/a0018301 · Cited by 3,174
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Voxel-Based Morphometry of the Human Brain: Methods and Applications
Mechelli, A., Price, C. J., Friston, K. J., & Ashburner, J. (2005) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/1573405054038726 · Cited by 894
Self-citationBrugha, T. S., & Cragg, D. (1990) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1990.tb01360.x · Cited by 883
Cumulative childhood stress and autoimmune diseases in adults
Dube, S. R., Fairweather, D., Pearson, W. S., Felitti, V. J., Anda, R. F., & Croft, J. B. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907888 · Cited by 820
Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei
Cohen, R. A., Grieve, S., Hoth, K. F., Paul, R. H., Sweet, L., Tate, D., Gunstad, J., Stroud, L., McCaffery, J., Hitsman, B., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.016 · Cited by 439
Training-induced structural changes in the adult human brain
Draganski, B., & May, A. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.015 · Cited by 437
Bluhm, R. L., Williamson, P. C., Osuch, E. A., Frewen, P. A., Stevens, T. K., Boksman, K., Neufeld, R. W. J., Théberge, J., & Lanius, R. A. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0925 · Cited by 422
Research works printed but not linked: 2
- Anisman H, 2009, J Psychiatry Neurosci, 34, 4
- Bluhm RL, 2009, J Psychiatry Neurosci, 34, 187
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Metadata
- Authors
- Papagni, S. A., Benetti, S., Arulanantham, S., McCrory, E., McGuire, P., & Mechelli, A.
- Affiliations
- King's College London (GB)
- University College London (GB)
- Corresponding author
- Mechelli, Andrea
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2010-10-31
- Volume
- 14
- Issue
- 2
- Pages
- 227-232
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W1745608382
- Cited by
- 126
- References
- 20
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 12 · 2012: 6
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Royal Society
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- life events, gray matter volume, brain structure, post-traumatic stress disorder, anterior cingulate cortex, hippocampus, parahippocampal gyrus, longitudinal change, healthy adults
- MeSH terms
- Adult, Brain, Female, Gyrus Cinguli, Hippocampus, Humans, Life Change Events, Longitudinal Studies, Magnetic Resonance Imaging, Male, Stress Disorders, Post-Traumatic, Prefrontal Cortex
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