The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students
Open accessAbstract
Oxytocin facilitates pro-social behaviour and is proposed as a regulatory factor controlling stress reactivity. Previous research on oxytocin and stress has focused on achievement-related stressors among male participants. The aims of the study were to (1) examine the influence of oxytocin on the affective and cortisol response to the Yale Interpersonal Stressor (YIPS), a live social rejection paradigm, and (2) to replicate the finding that women exhibit a greater cortisol response to interpersonal stress than men (Stroud et al. 2002). Sex differences in stress responses: Social rejection versus achievement stress. Biol Psychiat 53:318-327. Ninety-six undergraduate students underwent the YIPS, where participants were excluded from two separate conversations by two same-sex confederates. Salivary cortisol concentrations and mood were repeatedly measured throughout the study. Participants were administered, in a double-blind design, a single dose of intranasal oxytocin (24 IU) or placebo prior to beginning the YIPS. The YIPS elicited a significant negative mood response that was more pronounced in females than in males. However, no significant cortisol response to the stressor and no sex difference in cortisol reactivity were observed. A significant effect of drug condition on cortisol levels was observed. Participants who were administered oxytocin exhibited a decrease in cortisol levels, relative to placebo, during the YIPS, F (4, 184)=4.50, p<0.05. The study failed to replicate the sex difference in the cortisol response to interpersonal stress reported by Stroud et al. (2002). Intranasal oxytocin, however, appeared to reduce cortisol concentrations during an interpersonal challenge.
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“Additionally, other researchers have reported reductions in stress hormones following oxytocin administration in stressful situations without reductions in subjective anxiety measures (Cardoso et al., in press; Ditzen et al., 2009; Linnen et al., 2012).”
From Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study (2013) · cites this paper as Linnen et al., 2012
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Cites
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Maslahati, T., Glogau, F., Gómez, M. G., Buchholz, K., Dormann, L., Wingenfeld, K., Otte, C., Schultebraucks, K., & Roepke, S. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1421305
Altered association of plasmatic oxytocin with affective stress response in alcohol use disorder
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Epigenetic influences on affect and emotion regulation: Insights from the oxytocin system
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Metadata
- Authors
- Linnen, A.-M., Ellenbogen, M. A., Cardoso, C., & Joober, R.
- Affiliations
- Concordia University (CA)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Ellenbogen, Mark A.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2011-12-20
- Volume
- 15
- Issue
- 4
- Pages
- 393-402
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2012021931
- Cited by
- 104
- References
- 53
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 8 · 2012: 1
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- Canada Research Chairs
- Concordia University
- Fonds Québécois de la Recherche sur la Nature et les Technologies
- Social Sciences and Humanities Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- intranasal oxytocin, salivary cortisol, social rejection, interpersonal stress, sex differences in stress response, negative mood, stress reactivity, placebo effect, university students
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Affect, Double-Blind Method, Female, Humans, Hydrocortisone, Male, Menstrual Cycle, Oxytocin, Saliva, Sex Factors, Psychological Distance, Stress, Psychological
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