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Oxidatively damaged DNA in animals exposed to particles

Møller, Peter, Danielsen, Pernille Høgh, Jantzen, Kim, Roursgaard, Martin, Loft, Steffen·2013·Critical Reviews in Toxicology
DOI 10.3109/10408444.2012.756456
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Abstract

Exposure to combustion-derived particles, quartz and asbestos is associated with increased levels of oxidized and mutagenic DNA lesions. The aim of this survey was to critically assess the measurements of oxidatively damaged DNA as marker of particle-induced genotoxicity in animal tissues. Publications based on non-optimal assays of 8-oxo-7,8-dihydroguanine by antibodies and/or unrealistically high levels of 8-oxo-7,8-dihydroguanine (suggesting experimental problems due to spurious oxidation of DNA) reported more induction of DNA damage after exposure to particles than did the publications based on optimal methods. The majority of studies have used single intracavitary administration or inhalation with dose rates exceeding the pulmonary overload threshold, resulting in cytotoxicity and inflammation. It is unclear whether this is relevant for the much lower human exposure levels. Still, there was linear dose-response relationship for 8-oxo-7,8-dihydroguanine in lung tissue without obvious signs of a threshold. The dose-response function was also dependent on chemical composition and other characteristics of the administered particles, whereas dependence on species and strain could not be equivocally determined. Roles of cytotoxicity or inflammation for oxidatively induced DNA damage could not be documented or refuted. Studies on exposure to particles in the gastrointestinal tract showed consistently increased levels of 8-oxo-7,8-dihydroguanine in the liver. Collectively, there…

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Metadata

Authors
Møller, P., Danielsen, P. H., Jantzen, K., Roursgaard, M., & Loft, S.
Venue
Critical Reviews in Toxicology
Publisher
Informa UK Limited
Published
2013-01-25
Volume
43
Issue
2
Pages
96-118
ISSN
  • 1040-8444
  • 1547-6898
DOI
10.3109/10408444.2012.756456
Cited by
73
References
2
Language
en

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CoChat. (2026). Citation check: Oxidatively damaged DNA in animals exposed to particles. https://app.cochat.ai/papers/10.3109/10408444.2012.756456
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Møller, P., Danielsen, P. H., Jantzen, K., Roursgaard, M., & Loft, S. (2013). Oxidatively damaged DNA in animals exposed to particles. Critical Reviews in Toxicology. https://doi.org/10.3109/10408444.2012.756456