Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials
Open accessAbstract
Asbestos fibers are naturally occurring silicates that have been extensively used in the past, including house construction, but because of their toxicity, their use has been banned in 63 countries. Despite this, more than one million metric tons of asbestos are still consumed annually in countries where asbestos use has not been banned. Asbestos-related disease incidence is still increasing in several countries, including those countries that banned the use of asbestos more than 30 years ago. We highlight here recent knowledge obtained in experimental models about the mechanisms leading to tumor development following asbestos exposure, including genetic and epigenetic changes. Importantly, the landscape of alterations observed experimentally in tumor samples is consistent with alterations observed in clinical tumor samples; therefore, studies performed on early/precancer stages should help inform secondary prevention, which remains crucial in the absence of an efficient primary prevention. Knowledge gathered on asbestos should also help address future challenges, especially in view of the increased production of new materials that may behave similarly to asbestos fibers.
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Asbestos exposure is the most important risk factor in the formation of MPM, with a latency period of up to 40 years after exposure.
“Asbestos exposure is the most important risk factor in the formation of MPM, with a latency period of up to 40 years after exposure, even if the exact molecular mechanisms that explain its carcinogenicity are complex and not fully known [14,15].”
From Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma (2023) · cites this paper as [15]
ROS are highly chemically reactive molecules derived from deficient reduction in molecular oxygen and play a critical role as signaling molecules in tumorigenesis, including asbestos-mediated carcinogenesis.
“ROS are highly chemically reactive molecules, derived from the deficient reduction in molecular oxygen (O2) and playing a critical role as signaling molecules in tumorigenesis [68], including asbestos-mediated carcinogenesis [15,66,69].”
From Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma (2023) · cites this paper as [15]
Chronic oxidative stress with a huge release of ROS by frustrated macrophages and tumor cells is a second hallmark of mesothelioma carcinogenesis following asbestos fiber exposure.
“Chronic oxidative stress, with a huge release of ROS by frustrated macrophages and tumor cells, is a second hallmark of mesothelioma carcinogenesis following asbestos fibers exposure [15,66] (Figure 2).”
From Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma (2023) · cites this paper as [15]
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Self-citationHedgehog Signaling in Mesothelioma: 2019 Status
Felley‐Bosco, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01121 · Cited by 2 · see citing works
Self-citationEnvironmental impact and safety of functionalized nanofibers
Gaweł, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99461-3.00012-1
Felley‐Bosco, E. (2023) · Cancers · doi:10.3390/cancers15112969
Self-citationImmunotherapy resistance and strategies in malignant pleural mesothelioma
Xia, W., Li, S., Zeng, Q., Zhang, Y., 赵娟芝, Tan, X., Ju, S., Zou, W., Chen, C., Li, C., et al. (2026) · Cancer Drug Resistance · doi:10.20517/cdr.2025.215
- Authors
- Felley-Bosco, E., & MacFarlane, M.
- Affiliations
- Laboratory of Molecular Oncology, University Hospital Zurich, Sternwartstrasse 14, 8091 Zürich, Switzerland
- University of Cambridge (GB)
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-08-29
- Volume
- 31
- Issue
- 10
- Pages
- 994-1008
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2889101753
- Cited by
- 23
- References
- 158
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- Locations
- Chemical Research in Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Medical Research Council
- Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung (CRSII3_147697)
- Stiftung f?r Angewandte Krebsforschung
- Walter-Bruckerhoff-Stiftung
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Social Sciences › Health › Occupational Health and Global Justice
- Keywords
- asbestos, asbestos-related diseases, tumor development mechanisms, genetic alterations, epigenetic modifications, engineered nanomaterials, secondary prevention, asbestos exposure, carcinogenesis
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Air Pollutants, Asbestos, Female, Humans, Lung Neoplasms, Male, Mesothelioma, Mutation, Survival Rate, Tumor Suppressor Protein p53, Cyclin-Dependent Kinase Inhibitor p16, Tumor Suppressor Proteins, Ubiquitin Thiolesterase, Nanostructures
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