The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action
Abstract
Polychlorinated and polybrominated biphenyls are industrial chemical mixtures which have been implicated in numerous human poisonings in Taiwan and Japan (PCBs) and Michigan (PBBs). Moreover, these polyhalogenated biphenyls have been widely detected in the environment including the air, water, fish, wildlife, human adipose tissue, and blood and breast milk. A major problem associated with the analysis and toxicology of this group of chemicals is their chemical complexity (e.g., there are 209 possible PCB isomers and congeners) and the remarkable effects of structure on activity. This article will discuss the effects of structure on the biologic and toxic effects of individual PCB and PBB congeners as well as reconstituted mixtures. The results clearly show that like "dioxin" (or 2,3,7,8-TCDD), the PCBs and PBBs elicit their effects through a cytosolic receptor protein which preferentially binds with the toxins which are approximate isostereomers of 2,3,7,8-TCDD. The evidence for this mechanism of action will be discussed in detail.
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Citations
Cites
p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure
Hansch, C., & Fujita, T. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a035 · Cited by 2,313
Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370
Cited by
Safe, S. (1990) · Critical Reviews in Toxicology · doi:10.3109/10408449009089873 · Cited by 1,871
Self-citationSafe, S. H. (1986) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.26.040186.002103 · Cited by 710
Self-citationGiesy, J. P., & Kannan, K. (1998) · Critical Reviews in Toxicology · doi:10.1080/10408449891344263 · Cited by 494
Microcontaminants and reproductive impairment of the Forster's tern on Green Bay, Lake Michigan-1983
Kubiak, T. J., Harris, H. J., Smith, L. M., Schwartz, T. R., Stalling, D. L., Trick, J. A., Sileo, L., Docherty, D. E., & Erdman, T. C. (1989) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf01225009 · Cited by 406
Polychlorinated biphenyl congeners in Foxes in Germany from 1983 to 1991
Georgii, S., Bachour, G., Failing, K., Eskens, U., Elmadfa, I., & Brunn, H. (1994) · Archives of Environmental Contamination and Toxicology · doi:10.1007/bf00212786 · Cited by 48
Metadata
- Authors
- Safe, S., & Hutzinger, O.
- Venue
- CRC Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1984-01
- Volume
- 13
- Issue
- 4
- Pages
- 319-395
- ISSN
- 0045-6446 (ISSN-L)
- OpenAlex
- W2090742214
- Cited by
- 799
- References
- 2
- FWCI
- 30.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Safe, S., & Hutzinger, O. (1984). Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action. CRC Critical Reviews in Toxicology. https://doi.org/10.3109/10408448409023762
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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