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Epidemiological and Laboratory Evidence of PCB-lnduced Neurotoxicity

Seegal, Richard F.·1996·Critical Reviews in Toxicology

DOI 10.3109/10408449609037481

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Abstract

The purpose of this review is to provide a selective, but critical, assessment of important findings derived from both epidemiological and laboratory studies suggesting that: (1) exposure to polychlorinated biphenyls (PCBs) and related halogenated aromatic hydrocarbons induces significant neurological and behavioral dysfunctions in humans and laboratory animals, particularly following exposure during gestation and lactation; (2) the neurochemical actions of PCBs depend on their structure and the developmental status of the animal at the time of exposure; and (3) the mechanisms responsible for these changes may involve alterations in basic cellular signaling processes and endocrine function that influence the synthesis and activity of important central nervous system neurotransmitters, the organization of the developing brain, and the behavioral responses to these environmental contaminants.

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Authors: Seegal, R. F.
Affiliations: New York State Department of Health (US)
Corresponding author: Seegal, Richard F.
Venue: Critical Reviews in Toxicology
Publisher: Informa UK Limited
Published: 1996-01
Volume: 26
Issue: 6
Pages: 709-737
ISSN: 0045-6446 (ISSN-L)
1040-8444
1547-6898
DOI: 10.3109/10408449609037481
OpenAlex: W1975003944
Cited by: 242
References: 130
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 8
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Keywords: polychlorinated biphenyls, neurotoxicity, developmental neurotoxicity, prenatal exposure, lactational exposure, halogenated aromatic hydrocarbons, brain development, neurotransmitter synthesis, endocrine disruption, signal transduction, behavioral dysfunction, structure-activity relationship
MeSH terms: Adult, Animals, Humans, Infant, Nervous System Diseases, Polychlorinated Biphenyls

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Epidemiological and Laboratory Evidence of PCB-lnduced Neurotoxicity

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