The DOI matches its Crossref record; 128 of the 130 references it cites were found in a registry or an index.
Epidemiological and Laboratory Evidence of PCB-lnduced Neurotoxicity
Abstract
The purpose of this review is to provide a selective, but critical, assessment of important findings derived from both epidemiological and laboratory studies suggesting that: (1) exposure to polychlorinated biphenyls (PCBs) and related halogenated aromatic hydrocarbons induces significant neurological and behavioral dysfunctions in humans and laboratory animals, particularly following exposure during gestation and lactation; (2) the neurochemical actions of PCBs depend on their structure and the developmental status of the animal at the time of exposure; and (3) the mechanisms responsible for these changes may involve alterations in basic cellular signaling processes and endocrine function that influence the synthesis and activity of important central nervous system neurotransmitters, the organization of the developing brain, and the behavioral responses to these environmental contaminants.
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“The weight of evidence from epidemiological studies supports a negative association between developmental exposure to PCBs and neuropsychological function in infancy and childhood [ 56 , 95–99 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [95]
Citations
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Cited by
Sorted by citations
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035
Brominated Flame Retardants: A Novel Class of Developmental Neurotoxicants in Our Environment?
Eriksson, P., Jakobsson, E., & Fredriksson, A. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109903 · Cited by 593
Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants
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Metadata
- Authors
- Seegal, R. F.
- Affiliations
- New York State Department of Health (US)
- Corresponding author
- Seegal, Richard F.
- Venue
- Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 26
- Issue
- 6
- Pages
- 709-737
- ISSN
- 0045-6446 (ISSN-L)
- 1040-8444
- 1547-6898
- OpenAlex
- W1975003944
- Cited by
- 242
- References
- 130
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- polychlorinated biphenyls, neurotoxicity, developmental neurotoxicity, prenatal exposure, lactational exposure, halogenated aromatic hydrocarbons, brain development, neurotransmitter synthesis, endocrine disruption, signal transduction, behavioral dysfunction, structure-activity relationship
- MeSH terms
- Adult, Animals, Humans, Infant, Nervous System Diseases, Polychlorinated Biphenyls
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