The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Transport of Nanoparticles Across the Rat Nasal Mucosa
Abstract
The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particles were detected in the blood after 5 minutes. The number of particles in the blood peaked at 60 minutes, and then remained constant for a further 2 hours. The smallest particles (20 nm) showed greater uptake than the largest particles investigated (1000 nm). The total maximum uptake seen for the smallest particles was in the order of 3.25% of administered dose. 100 nm particles coated with chitosan showed an increase in both the extent and rate of uptake, with the concentration in the blood peaking at 15 minutes rather than at 60 minutes. It is suggested that transport of the particles across the nasal membrane is due mainly to a transcellular transport mechanisms by the nasal associated lymphoid tissue (NALT), especially the M-cell like cells. However, some paracellular transport cannot totally be ruled out for the smallest particles, especially if coated with chitosan.
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Citations
Cites
Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
Tobío, M., Gref, R., Sánchez, A., Langer, R., & Alonso, M. J. (1998) · Pharmaceutical Research · doi:10.1023/a:1011922819926 · Cited by 402
Lectin-mediated mucosal delivery of drugs and microparticles
Clark, M. A., Hirst, B. H., & Jepson, M. A. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00070-3 · Cited by 236
Hillery, A. M., & Florence, A. T. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)04353-5 · Cited by 81
Cited by
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523
Hydrogels in controlled release formulations: Network design and mathematical modeling
Lin, C.-C., & Metters, A. T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.004 · Cited by 1,768
Nanoparticles for direct nose-to-brain delivery of drugs
Mistry, A., Stolnik, S., & Illum, L. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.019 · Cited by 734
Self-citationIn Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles
Su, X., Fricke, J., Kavanagh, D. G., & Irvine, D. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100390w · Cited by 287
Dyer, A. M., Hinchcliffe, M., Watts, P., Castile, J., Jabbal-Gill, I., Nankervis, R., Smith, A., & Illum, L. (2002) · Pharmaceutical Research · doi:10.1023/a:1016418523014 · Cited by 280
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Metadata
- Authors
- Brooking, J., Davis, S. S., & Illum, L.
- Venue
- Journal of Drug Targeting
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 9
- Issue
- 4
- Pages
- 267-279
- ISSN
- 1026-7158 (ISSN-L)
- 1061-186X
- 1029-2330
- OpenAlex
- W2042977409
- Cited by
- 206
- References
- 3
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
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