Cited by 236Advanced Drug Delivery SystemsGlycosylation and Glycoproteins ResearchInhalation and Respiratory Drug Delivery

Lectin-mediated mucosal delivery of drugs and microparticles

Open access
Clark, M.Ann, Hirst, Barry H, Jepson, Mark A·2000·Advanced Drug Delivery Reviews

Abstract

Absorption of drugs and vaccines at mucosal surfaces may be enhanced by conjugation to appropriate bioadhesins which bind to mucosal epithelia. Bioadhesins might also permit cell- and site-selective targeting. One approach is to exploit surface carbohydrates on mucosal epithelial cells for lectin-mediated delivery. We review work supporting the use of lectins as mucosal bioadhesins in the gastrointestinal and respiratory tracts, the oral cavity and the eye. The gastrointestinal tract is particularly favoured for mucosal delivery. Many studies have demonstrated that the antigen sampling intestinal M cells offer a portal for absorption of colloidal delivery vehicles. Evidence is presented that M cell targeting may be achieved using M cell-specific lectins, microbial adhesins or immunoglobulins. While many hurdles must be overcome before mucosal bioadhesins can guarantee consistent, safe, effective mucosal delivery, this is an exciting area of research that has important implications for future drug and vaccine formulation.

Integrity signals

Registry

Crossref · 10.1016/s0169-409x(00)00070-3

Cites

122 of 122 references verified0 citation errors · 0 not checkable

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  • Lectins are often toxic and susceptible to proteolytic degradation in GI tract, rendering some inappropriate for in vivo application.

    “lectins are often toxic and susceptible to proteolytic degradation in the GI tract, which renders some of them inappropriate for in vivo application [105,117].”

    From Use of lectin-functionalized particles for oral immunotherapy (2012) · cites this paper as [105]

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Authors
Clark, M. A., Hirst, B. H., & Jepson, M. A.
Affiliations
  • Newcastle University (GB)
  • University of Bristol (GB)
Corresponding author
Jepson, Mark A
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2000-09
Volume
43
Issue
2-3
Pages
207-223
ISSN
0169-409X (ISSN-L)
OpenAlex
W2063013932
Cited by
236
References
121
Citations by year
2026: 4 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 14 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 17
FWCI
1.41
Type
journal article
Language
en
Open access
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords
lectins, mucosal drug delivery, M cells, intestinal mucosa, respiratory mucosa, oral mucosa, ocular drug delivery, microparticles, colloidal drug delivery, vaccine delivery, gastrointestinal tract
MeSH terms
Animals, Gastric Mucosa, Humans, Intestinal Absorption, Intestinal Mucosa, Nasal Mucosa, Vaccines, Drug Delivery Systems, Lectins

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